ESC Working Group on Myocardial Function Position Paper: how to study the right ventricle in experimental models

Adelino F. Leite-Moreira; Andre P. Lourenco; Jean-Luc Balligand; Johann Bauersachs; Angela Clerk; Leon J. De Windt; Stephane Heymans; Denise Hilfiker-Kleiner; Emilio Hirsch; Guido Iaccarino; Karol A. Kaminski; Ralph Knoell; Manuel Mayr; Guido Tarone; Thomas Thum; Carlo G. Tocchetti

doi:10.1002/ejhf.66

ESC Working Group on Myocardial Function Position Paper: how to study the right ventricle in experimental models

Adelino F. Leite-Moreira^*, Andre P. Lourenco, Jean-Luc Balligand, Johann Bauersachs, Angela Clerk, Leon J. De Windt, Stephane Heymans, Denise Hilfiker-Kleiner, Emilio Hirsch, Guido Iaccarino, Karol A. Kaminski, Ralph Knoell, Manuel Mayr, Guido Tarone, Thomas Thum, Carlo G. Tocchetti

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The right ventricle has become an increasing focus in cardiovascular research. In this position paper, we give a brief overview of the specific pathophysiological features of the right ventricle, with particular emphasis on functional and molecular modifications as well as therapeutic strategies in chronic overload, highlighting the differences from the left ventricle. Importantly, we put together recommendations on promising topics of research in the field, experimental study design, and functional evaluation of the right ventricle in experimental models, from non-invasive methodologies to haemodynamic evaluation and ex vivo set-ups.

Original language	English
Pages (from-to)	509-518
Journal	European journal of heart failure
Volume	16
Issue number	5
DOIs	https://doi.org/10.1002/ejhf.66
Publication status	Published - May 2014

Keywords

Functional evaluation
Right ventricle function
Experimental myocardial preparations
Haemodynamics
Cardiac imaging
Chronic overload

Access to Document

10.1002/ejhf.66

Cite this

Leite-Moreira, A. F., Lourenco, A. P., Balligand, J.-L., Bauersachs, J., Clerk, A., De Windt, L. J., Heymans, S., Hilfiker-Kleiner, D., Hirsch, E., Iaccarino, G., Kaminski, K. A., Knoell, R., Mayr, M., Tarone, G., Thum, T., & Tocchetti, C. G. (2014). ESC Working Group on Myocardial Function Position Paper: how to study the right ventricle in experimental models. European journal of heart failure, 16(5), 509-518. https://doi.org/10.1002/ejhf.66

@article{467df19c0aad4a7290b72aa9c52a0be9,

title = "ESC Working Group on Myocardial Function Position Paper: how to study the right ventricle in experimental models",

abstract = "The right ventricle has become an increasing focus in cardiovascular research. In this position paper, we give a brief overview of the specific pathophysiological features of the right ventricle, with particular emphasis on functional and molecular modifications as well as therapeutic strategies in chronic overload, highlighting the differences from the left ventricle. Importantly, we put together recommendations on promising topics of research in the field, experimental study design, and functional evaluation of the right ventricle in experimental models, from non-invasive methodologies to haemodynamic evaluation and ex vivo set-ups.",

keywords = "Functional evaluation, Right ventricle function, Experimental myocardial preparations, Haemodynamics, Cardiac imaging, Chronic overload",

author = "Leite-Moreira, {Adelino F.} and Lourenco, {Andre P.} and Jean-Luc Balligand and Johann Bauersachs and Angela Clerk and {De Windt}, {Leon J.} and Stephane Heymans and Denise Hilfiker-Kleiner and Emilio Hirsch and Guido Iaccarino and Kaminski, {Karol A.} and Ralph Knoell and Manuel Mayr and Guido Tarone and Thomas Thum and Tocchetti, {Carlo G.}",

year = "2014",

month = may,

doi = "10.1002/ejhf.66",

language = "English",

volume = "16",

pages = "509--518",

journal = "European journal of heart failure",

issn = "1388-9842",

publisher = "Wiley",

number = "5",

}

Leite-Moreira, AF, Lourenco, AP, Balligand, J-L, Bauersachs, J, Clerk, A, De Windt, LJ , Heymans, S, Hilfiker-Kleiner, D, Hirsch, E, Iaccarino, G, Kaminski, KA, Knoell, R, Mayr, M, Tarone, G, Thum, T & Tocchetti, CG 2014, 'ESC Working Group on Myocardial Function Position Paper: how to study the right ventricle in experimental models', European journal of heart failure, vol. 16, no. 5, pp. 509-518. https://doi.org/10.1002/ejhf.66

TY - JOUR

T1 - ESC Working Group on Myocardial Function Position Paper: how to study the right ventricle in experimental models

AU - Leite-Moreira, Adelino F.

AU - Lourenco, Andre P.

AU - Balligand, Jean-Luc

AU - Bauersachs, Johann

AU - Clerk, Angela

AU - De Windt, Leon J.

AU - Heymans, Stephane

AU - Hilfiker-Kleiner, Denise

AU - Hirsch, Emilio

AU - Iaccarino, Guido

AU - Kaminski, Karol A.

AU - Knoell, Ralph

AU - Mayr, Manuel

AU - Tarone, Guido

AU - Thum, Thomas

AU - Tocchetti, Carlo G.

PY - 2014/5

Y1 - 2014/5

N2 - The right ventricle has become an increasing focus in cardiovascular research. In this position paper, we give a brief overview of the specific pathophysiological features of the right ventricle, with particular emphasis on functional and molecular modifications as well as therapeutic strategies in chronic overload, highlighting the differences from the left ventricle. Importantly, we put together recommendations on promising topics of research in the field, experimental study design, and functional evaluation of the right ventricle in experimental models, from non-invasive methodologies to haemodynamic evaluation and ex vivo set-ups.

AB - The right ventricle has become an increasing focus in cardiovascular research. In this position paper, we give a brief overview of the specific pathophysiological features of the right ventricle, with particular emphasis on functional and molecular modifications as well as therapeutic strategies in chronic overload, highlighting the differences from the left ventricle. Importantly, we put together recommendations on promising topics of research in the field, experimental study design, and functional evaluation of the right ventricle in experimental models, from non-invasive methodologies to haemodynamic evaluation and ex vivo set-ups.

KW - Functional evaluation

KW - Right ventricle function

KW - Experimental myocardial preparations

KW - Haemodynamics

KW - Cardiac imaging

KW - Chronic overload

U2 - 10.1002/ejhf.66

DO - 10.1002/ejhf.66

M3 - Article

C2 - 24574252

SN - 1388-9842

VL - 16

SP - 509

EP - 518

JO - European journal of heart failure

JF - European journal of heart failure

IS - 5

ER -