ESC Working Group on Myocardial Function Position Paper: how to study the right ventricle in experimental models

Adelino F. Leite-Moreira*, Andre P. Lourenco, Jean-Luc Balligand, Johann Bauersachs, Angela Clerk, Leon J. De Windt, Stephane Heymans, Denise Hilfiker-Kleiner, Emilio Hirsch, Guido Iaccarino, Karol A. Kaminski, Ralph Knoell, Manuel Mayr, Guido Tarone, Thomas Thum, Carlo G. Tocchetti

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

The right ventricle has become an increasing focus in cardiovascular research. In this position paper, we give a brief overview of the specific pathophysiological features of the right ventricle, with particular emphasis on functional and molecular modifications as well as therapeutic strategies in chronic overload, highlighting the differences from the left ventricle. Importantly, we put together recommendations on promising topics of research in the field, experimental study design, and functional evaluation of the right ventricle in experimental models, from non-invasive methodologies to haemodynamic evaluation and ex vivo set-ups.
Original languageEnglish
Pages (from-to)509-518
JournalEuropean journal of heart failure
Volume16
Issue number5
DOIs
Publication statusPublished - May 2014

Keywords

  • Functional evaluation
  • Right ventricle function
  • Experimental myocardial preparations
  • Haemodynamics
  • Cardiac imaging
  • Chronic overload

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