Endothelial factors in the pathogenesis and treatment of chronic kidney disease Part II: Role in disease conditions: a joint consensus statement from the European Society of Hypertension Working Group on Endothelin and Endothelial Factors and the Japanese Society of Hypertension

Gian Paolo Rossi*, Teresa M. Seccia, Matthias Barton, A. H. Jan Danser, Peter W. de Leeuw, Neeraj Dhaun, Damiano Rizzoni, Patrick Rossignol, Luis-Miguel Ruilope, Anton H. van den Meiracker, Sadayoshi Ito, Naoyuki Hasebe, David J. Webb

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Web of Science)

Abstract

After examining in Part I the general mechanisms of endothelial cell injury in the kidney, the Working Group on Endothelin and Endothelial Factors of the European Society of Hypertension and the Japanese Society of Hypertension will herein review current knowledge on the role of endothelial dysfunction in multiple disease conditions that affect the kidney, including diabetes mellitus, preeclampsia, solid organ transplantation, hyperhomocysteinemia and antiangiogenic therapy in cancer. The few available randomized controlled clinical trials specifically designed to evaluate strategies for correcting endothelial dysfunction in patients with hypertension and/or chronic kidney disease are also discussed alongside their cardiovascular and renal outcomes.
Original languageEnglish
Pages (from-to)462-471
Number of pages10
JournalJournal of Hypertension
Volume36
Issue number3
DOIs
Publication statusPublished - 1 Mar 2018

Keywords

  • cancer
  • diabetes mellitus
  • endothelin
  • endothelium
  • hyperhomocysteinemia
  • hypertension
  • kidney
  • kidney transplantation
  • preeclampsia
  • ANGIOTENSIN-ALDOSTERONE SYSTEM
  • HEART-BEATING DONORS
  • ASYMMETRIC DIMETHYLARGININE ADMA
  • CHRONIC TRANSPLANT NEPHROPATHY
  • PORCINE LIVER-TRANSPLANTATION
  • PIG PANCREAS TRANSPLANTATION
  • TYPE-2 DIABETIC-NEPHROPATHY
  • RANDOMIZED CONTROLLED-TRIAL
  • RENAL-ALLOGRAFT REJECTION
  • CORONARY-ARTERY-DISEASE

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