TY - JOUR
T1 - Endothelial factors in the pathogenesis and treatment of chronic kidney disease Part II: Role in disease conditions: a joint consensus statement from the European Society of Hypertension Working Group on Endothelin and Endothelial Factors and the Japanese Society of Hypertension
AU - Rossi, Gian Paolo
AU - Seccia, Teresa M.
AU - Barton, Matthias
AU - Danser, A. H. Jan
AU - de Leeuw, Peter W.
AU - Dhaun, Neeraj
AU - Rizzoni, Damiano
AU - Rossignol, Patrick
AU - Ruilope, Luis-Miguel
AU - van den Meiracker, Anton H.
AU - Ito, Sadayoshi
AU - Hasebe, Naoyuki
AU - Webb, David J.
PY - 2018/3/1
Y1 - 2018/3/1
N2 - After examining in Part I the general mechanisms of endothelial cell injury in the kidney, the Working Group on Endothelin and Endothelial Factors of the European Society of Hypertension and the Japanese Society of Hypertension will herein review current knowledge on the role of endothelial dysfunction in multiple disease conditions that affect the kidney, including diabetes mellitus, preeclampsia, solid organ transplantation, hyperhomocysteinemia and antiangiogenic therapy in cancer. The few available randomized controlled clinical trials specifically designed to evaluate strategies for correcting endothelial dysfunction in patients with hypertension and/or chronic kidney disease are also discussed alongside their cardiovascular and renal outcomes.
AB - After examining in Part I the general mechanisms of endothelial cell injury in the kidney, the Working Group on Endothelin and Endothelial Factors of the European Society of Hypertension and the Japanese Society of Hypertension will herein review current knowledge on the role of endothelial dysfunction in multiple disease conditions that affect the kidney, including diabetes mellitus, preeclampsia, solid organ transplantation, hyperhomocysteinemia and antiangiogenic therapy in cancer. The few available randomized controlled clinical trials specifically designed to evaluate strategies for correcting endothelial dysfunction in patients with hypertension and/or chronic kidney disease are also discussed alongside their cardiovascular and renal outcomes.
KW - cancer
KW - diabetes mellitus
KW - endothelin
KW - endothelium
KW - hyperhomocysteinemia
KW - hypertension
KW - kidney
KW - kidney transplantation
KW - preeclampsia
KW - ANGIOTENSIN-ALDOSTERONE SYSTEM
KW - HEART-BEATING DONORS
KW - ASYMMETRIC DIMETHYLARGININE ADMA
KW - CHRONIC TRANSPLANT NEPHROPATHY
KW - PORCINE LIVER-TRANSPLANTATION
KW - PIG PANCREAS TRANSPLANTATION
KW - TYPE-2 DIABETIC-NEPHROPATHY
KW - RANDOMIZED CONTROLLED-TRIAL
KW - RENAL-ALLOGRAFT REJECTION
KW - CORONARY-ARTERY-DISEASE
U2 - 10.1097/HJH.0000000000001600
DO - 10.1097/HJH.0000000000001600
M3 - Article
C2 - 29135628
VL - 36
SP - 462
EP - 471
JO - Journal of Hypertension
JF - Journal of Hypertension
SN - 0263-6352
IS - 3
ER -