Encapsulation of lipids as emulsion-alginate beads reduces food intake: a randomized placebo-controlled cross-over human trial in overweight adults

Meinou N. Corstens, Freddy J. Troost, Annick M. E. Alleleyn, Tim Klaassen, Claire C. Berton-Carabin, Karin Schroen, Ad A. M. Masclee*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Web of Science)

Abstract

The objective of this study was to investigate the efficacy of lipid emulsions encapsulated in calcium-alginate beads in reducing food intake and appetite sensations. These emulsion-alginate beads were ingested in a yogurt (active) and compared to an equienergetic yogurt containing nonencapsulated nutrients with comparable sensory properties (control) in a randomized placebo-controlled trial with crossover design. Thirty-three healthy overweight volunteers (mean age: 43 years; body mass index: 27.7 kg/m(2); 14 male) received the 2 treatments. Test days started with a standardized small breakfast (t = 0) followed by an active or control yogurt (t = 90 minutes). Appetite sensations and gastrointestinal symptoms were monitored prior to and after consumption of the yogurt, and food intake was measured during ad libitum pasta meal consumption (t = 210 minutes). The hypothesis for this study was that delayed release of encapsulated lipids suppresses appetite sensations and reduces food intake. Food intake was significantly reduced with 51 +/- 20 kcal (213 +/- 84 kJ) (P =.016) after intake of the active yogurt (770 +/- 38 kcal (3222 +/- 159 kJ)) compared to the control (821 +/- 40 kcal (3435 +/- 167 kJ)). The approach that we chose is promising to reduce food intake and could contribute to the development of an easy-to-use product for weight management. (C) 2018 Elsevier Inc. All rights reserved.

Original languageEnglish
Pages (from-to)86-94
Number of pages9
JournalNutrition Research
Volume63
DOIs
Publication statusPublished - Mar 2019

Keywords

  • Appetite
  • Human trial
  • Ileal brake
  • Weight management
  • Encapsulated lipid
  • FREE FATTY-ACIDS
  • DROPLET SIZE
  • ILEAL BRAKE
  • APPETITE
  • SATIETY
  • LIPOLYSIS
  • DIGESTION
  • IMPACT
  • INTERFACES
  • BEHAVIOR

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