Elucidating the underlying mechanisms of inflammation caused by perinatal asphyxia and chorioamnionitis

E. Vlassaks

Research output: ThesisDoctoral ThesisInternal

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Perinatal asphyxia and chorioamnionitis are both important neonatal complications that can lead to serious organ disorders and even neonatal death. This dissertation studied the underlying mechanisms of inflammation in these complications to reach new insights and treatment therapies. An important connection was shown between the production of cytokines, ceramides and the occurrence of cell death after foetal asphyxia. This interaction can play an important role in neuroprotection. Furthermore the research has shown that prenatal complications such as chorioamniotitis can lead to liver inflammation with disorders in the lipid metabolism as a consequence.

Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Maastricht University
  • Vles, Johan, Supervisor
  • de Baets, Marc, Supervisor
  • Kramer, B.W., Supervisor, External person
  • Gavilanes, A.D.W., Co-Supervisor
Award date17 Dec 2012
Place of Publication’s-Hertogenbosch
Print ISBNs9789088915154
Publication statusPublished - 1 Jan 2012


  • perinatal asphyxia
  • fetal asphyxia
  • chorioamnionitis
  • inflammation
  • liver
  • brain

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