Electrophysiological Properties of Rat Vestibular Labyrinth and Their Effect on Parameters of Transmitted Voltage Pulses

V. P. Demkin; V. V. Udut; P. P. Shchetinin; M. V. Svetlik; S. V. Mel'nichuk; A. P. Shchetinina; M. O. Pleshkov; D. N. Starkov; O. V. Demkin; H. Kingma

doi:10.1007/s10517-018-4063-4

Electrophysiological Properties of Rat Vestibular Labyrinth and Their Effect on Parameters of Transmitted Voltage Pulses

V. P. Demkin, V. V. Udut, P. P. Shchetinin^*, M. V. Svetlik, S. V. Mel'nichuk, A. P. Shchetinina, M. O. Pleshkov, D. N. Starkov, O. V. Demkin, H. Kingma

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

We propose a new approach to optimization of electrical stimulation of the vestibular nerve and improving the transfer function of vestibular implant. A mathematical model of the vestibular organ is developed based on its anatomy, the model premises, 3D-analysis of MRI and CT images, and mathematical description of physical processes underlying propagation of alternating electric current across the tissues of vestibular labyrinth. This approach was tested in vitro on the rat vestibular apparatus and had been examined anatomically prior to the development of its mathematical model and equivalent electrical circuit. The experimental and theoretical values of changes of the gain-phase characteristics of vestibular tissues in relation to location of the reference electrode obtained in this study can be used to optimize the electrical stimulation of vestibular nerve.

Original language	English
Pages (from-to)	707-711
Number of pages	5
Journal	Bulletin of Experimental Biology and Medicine
Volume	164
Issue number	6
DOIs	https://doi.org/10.1007/s10517-018-4063-4
Publication status	Published - 1 Apr 2018

Keywords

vestibular implant
in vitro vestibular apparatus
anatomic structure
mathematical model
stimulating voltage pulses

Access to Document

10.1007/s10517-018-4063-4

Cite this

Demkin, V. P., Udut, V. V., Shchetinin, P. P., Svetlik, M. V., Mel'nichuk, S. V., Shchetinina, A. P., Pleshkov, M. O., Starkov, D. N., Demkin, O. V., & Kingma, H. (2018). Electrophysiological Properties of Rat Vestibular Labyrinth and Their Effect on Parameters of Transmitted Voltage Pulses. Bulletin of Experimental Biology and Medicine, 164(6), 707-711. https://doi.org/10.1007/s10517-018-4063-4

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abstract = "We propose a new approach to optimization of electrical stimulation of the vestibular nerve and improving the transfer function of vestibular implant. A mathematical model of the vestibular organ is developed based on its anatomy, the model premises, 3D-analysis of MRI and CT images, and mathematical description of physical processes underlying propagation of alternating electric current across the tissues of vestibular labyrinth. This approach was tested in vitro on the rat vestibular apparatus and had been examined anatomically prior to the development of its mathematical model and equivalent electrical circuit. The experimental and theoretical values of changes of the gain-phase characteristics of vestibular tissues in relation to location of the reference electrode obtained in this study can be used to optimize the electrical stimulation of vestibular nerve.",

keywords = "vestibular implant, in vitro vestibular apparatus, anatomic structure, mathematical model, stimulating voltage pulses",

author = "Demkin, {V. P.} and Udut, {V. V.} and Shchetinin, {P. P.} and Svetlik, {M. V.} and Mel'nichuk, {S. V.} and Shchetinina, {A. P.} and Pleshkov, {M. O.} and Starkov, {D. N.} and Demkin, {O. V.} and H. Kingma",

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Demkin, VP, Udut, VV, Shchetinin, PP, Svetlik, MV, Mel'nichuk, SV, Shchetinina, AP, Pleshkov, MO, Starkov, DN, Demkin, OV & Kingma, H 2018, 'Electrophysiological Properties of Rat Vestibular Labyrinth and Their Effect on Parameters of Transmitted Voltage Pulses', Bulletin of Experimental Biology and Medicine, vol. 164, no. 6, pp. 707-711. https://doi.org/10.1007/s10517-018-4063-4

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AU - Demkin, V. P.

AU - Udut, V. V.

AU - Shchetinin, P. P.

AU - Svetlik, M. V.

AU - Mel'nichuk, S. V.

AU - Shchetinina, A. P.

AU - Pleshkov, M. O.

AU - Starkov, D. N.

AU - Demkin, O. V.

AU - Kingma, H.

PY - 2018/4/1

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AB - We propose a new approach to optimization of electrical stimulation of the vestibular nerve and improving the transfer function of vestibular implant. A mathematical model of the vestibular organ is developed based on its anatomy, the model premises, 3D-analysis of MRI and CT images, and mathematical description of physical processes underlying propagation of alternating electric current across the tissues of vestibular labyrinth. This approach was tested in vitro on the rat vestibular apparatus and had been examined anatomically prior to the development of its mathematical model and equivalent electrical circuit. The experimental and theoretical values of changes of the gain-phase characteristics of vestibular tissues in relation to location of the reference electrode obtained in this study can be used to optimize the electrical stimulation of vestibular nerve.

KW - vestibular implant

KW - in vitro vestibular apparatus

KW - anatomic structure

KW - mathematical model

KW - stimulating voltage pulses

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