EGFRvIII expression triggers a metabolic dependency and therapeutic vulnerability sensitive to autophagy inhibition

Barry Jutten, Tom G. Keulers, Hanneke J. M. Peeters, Marco B. E. Schaaf, Kim G. M. Savelkouls, Inge Compter, Ruud Clarijs, Olaf E. M. G. Schijns, Linda Ackermans, Onno P. M. Teernstra, Marijke I. Zonneveld, Resi M. E. Colaris, Ludwig Dubois, Marc A. Vooijs, Johan Bussink, Julio Sotelo, Jan Theys, Guido Lammering, Kasper M. A. Rouschop

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)283-295
Number of pages13
JournalAutophagy
Volume14
Issue number2
DOIs
Publication statusPublished - 1 Jan 2018

Keywords

  • Autophagy
  • chloroquine
  • EGFR
  • EGFRvIII
  • glioblastoma
  • hypoxia
  • metabolic stress radiotherapy
  • starvation
  • GROWTH-FACTOR RECEPTOR
  • CONFERS ENHANCED TUMORIGENICITY
  • VARIANT-III CONTRIBUTES
  • GLIOBLASTOMA-MULTIFORME
  • RADIATION-THERAPY
  • HYPOXIA TOLERANCE
  • PROGNOSTIC VALUE
  • TUMOR HYPOXIA
  • CANCER
  • CELLS

Cite this