Efficacy of gene therapy-delivered cytosine deaminase is determined by enzymatic activity but not expression

L. Dubois; T. Dresselaers; W. Landuyt; K. Paesmans; A. Mengesha; B. G. Wouters; P. Van Hecke; J. Theys; P. Lambin

doi:10.1038/sj.bjc.6603624

Efficacy of gene therapy-delivered cytosine deaminase is determined by enzymatic activity but not expression

L. Dubois, T. Dresselaers, W. Landuyt, K. Paesmans, A. Mengesha, B. G. Wouters, P. Van Hecke, J. Theys^*, P. Lambin

^*Corresponding author for this work

GROW - Innovative Cancer Diagnostics & Therapy

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The potential utility of tumour-selective 5-fluorouracil treatment using attenuated Salmonella serovar typhimurium recombinant for cytosine deaminase (TAPET-CD) has been documented in experimental settings. The present data demonstrate that in vivo F-19-magnetic resonance spectroscopy measurements allow the outcome prediction of this prokaryotic-based therapy, demonstrating the necessity of non-invasive real-time imaging techniques for treatment monitoring.

Original language	English
Pages (from-to)	758-761
Number of pages	4
Journal	British Journal of Cancer
Volume	96
Issue number	5
DOIs	https://doi.org/10.1038/sj.bjc.6603624
Publication status	Published - 12 Mar 2007

Keywords

F-19-MRS
Salmonella typhimurium
gene therapy
cytosine deaminase
xenograft human tumour
NMR-SPECTROSCOPY
SALMONELLA
5-FLUOROURACIL
F-19
PHARMACOKINETICS
CARCINOMA
TUMORS

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10.1038/sj.bjc.6603624Licence: CC BY-NC-SA

Cite this

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title = "Efficacy of gene therapy-delivered cytosine deaminase is determined by enzymatic activity but not expression",

abstract = "The potential utility of tumour-selective 5-fluorouracil treatment using attenuated Salmonella serovar typhimurium recombinant for cytosine deaminase (TAPET-CD) has been documented in experimental settings. The present data demonstrate that in vivo F-19-magnetic resonance spectroscopy measurements allow the outcome prediction of this prokaryotic-based therapy, demonstrating the necessity of non-invasive real-time imaging techniques for treatment monitoring.",

keywords = "F-19-MRS, Salmonella typhimurium, gene therapy, cytosine deaminase, xenograft human tumour, NMR-SPECTROSCOPY, SALMONELLA, 5-FLUOROURACIL, F-19, PHARMACOKINETICS, CARCINOMA, TUMORS",

author = "L. Dubois and T. Dresselaers and W. Landuyt and K. Paesmans and A. Mengesha and Wouters, {B. G.} and {Van Hecke}, P. and J. Theys and P. Lambin",

year = "2007",

month = mar,

day = "12",

doi = "10.1038/sj.bjc.6603624",

language = "English",

volume = "96",

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journal = "British Journal of Cancer",

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T1 - Efficacy of gene therapy-delivered cytosine deaminase is determined by enzymatic activity but not expression

AU - Dubois, L.

AU - Dresselaers, T.

AU - Landuyt, W.

AU - Paesmans, K.

AU - Mengesha, A.

AU - Wouters, B. G.

AU - Van Hecke, P.

AU - Theys, J.

AU - Lambin, P.

PY - 2007/3/12

Y1 - 2007/3/12

N2 - The potential utility of tumour-selective 5-fluorouracil treatment using attenuated Salmonella serovar typhimurium recombinant for cytosine deaminase (TAPET-CD) has been documented in experimental settings. The present data demonstrate that in vivo F-19-magnetic resonance spectroscopy measurements allow the outcome prediction of this prokaryotic-based therapy, demonstrating the necessity of non-invasive real-time imaging techniques for treatment monitoring.

AB - The potential utility of tumour-selective 5-fluorouracil treatment using attenuated Salmonella serovar typhimurium recombinant for cytosine deaminase (TAPET-CD) has been documented in experimental settings. The present data demonstrate that in vivo F-19-magnetic resonance spectroscopy measurements allow the outcome prediction of this prokaryotic-based therapy, demonstrating the necessity of non-invasive real-time imaging techniques for treatment monitoring.

KW - F-19-MRS

KW - Salmonella typhimurium

KW - gene therapy

KW - cytosine deaminase

KW - xenograft human tumour

KW - NMR-SPECTROSCOPY

KW - SALMONELLA

KW - 5-FLUOROURACIL

KW - F-19

KW - PHARMACOKINETICS

KW - CARCINOMA

KW - TUMORS

U2 - 10.1038/sj.bjc.6603624

DO - 10.1038/sj.bjc.6603624

M3 - Article

SN - 0007-0920

VL - 96

SP - 758

EP - 761

JO - British Journal of Cancer

JF - British Journal of Cancer

IS - 5

ER -