Effects on (neuro) developmental and behavioral outcome at 2 years of age of induced labor compared with expectant management in intrauterine growth-restricted infants: long-term outcomes of the DIGITAT trial

Linda van Wyk*, Kim E. Boers, Joris A. M. van der Post, Maria G. van Pampus, Aleid G. van Wassenaer, Anneloes L. van Baar, Marc E. A. Spaanderdam, Jeroen H. Becker, Anneke Kwee, Johannes J. Duvekot, Henk A. Bremer, Friso M. C. Delemarre, Kitty W. M. Bloemenkamp, Christianne J. M. de Groot, Christine Willekes, Frans J. M. E. Roumen, Jan M. M. van Lith, Ben W. J. Mol, Saskia le Cessie, Sicco A. Scherjon

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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OBJECTIVE: We sought to study long-term (neuro) developmental and behavioral outcome of pregnancies complicated by intrauterine growth restriction at term in relation to induction of labor or an expectant management. STUDY DESIGN: Parents of 2-year-old children included in the Disproportionate Intrauterine Growth Intervention Trial at Term (DIGITAT) answered the Ages and Stages Questionnaire (ASQ) and Child Behavior Checklist (CBCL). RESULTS: We approached 582 (89.5%) of 650 parents. The response rate was 50%. Of these children, 27% had an abnormal score on the ASQ and 13% on the CBCL. Results of the ASQ and the CBCL for the 2 policies were comparable. Low birthweight, positive Morbidity Assessment Index score, and admission to intermediate care increased the risk of an abnormal outcome of the ASQ. This effect was not seen for the CBCL. CONCLUSION: In women with intrauterine growth restriction at term, neither a policy of induction of labor nor expectant management affect developmental and behavioral outcome when compared to expectant management.
Original languageEnglish
Pages (from-to)e1-7
JournalAmerican Journal of Obstetrics and Gynecology
Issue number5
Publication statusPublished - May 2012


  • Ages and Stages Questionnaire
  • Child Behavior Checklist
  • DIGITAT trial
  • intrauterine growth restriction
  • long-term outcome

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