Effects of tryptophan depletion on anxiety and on panic provoked by carbon dioxide challenge.

T. Klaassen, J. Klumperbeek, N.E.P. Deutz, H.M. van Praag, E.J.L. Griez

Research output: Contribution to journalArticleAcademicpeer-review

74 Citations (Scopus)

Abstract

Department of Psychiatry and Neuropsychology, Maastricht University, The Netherlands.

Results of several studies suggest that anxiety is under serotonergic control. We studied the influence of tryptophan depletion on generalized anxiety and on the response to a 35% carbon dioxide (CO2) challenge. Fifteen healthy male volunteers received both a mixture of amino acids without tryptophan and a placebo mixture under double-blind conditions. The tryptophan-free mixture led to an 80% decrease in blood tryptophan levels compared to the placebo. There was a significant increase in anxiety on the Spielberger Anxiety Inventory and a trend towards more tension on the Profile of Mood States-'tension' items, both of which were interpreted as increased nervousness. Furthermore, a significant increase in neurovegetative panic symptoms occurred after the CO2 challenge. We conclude that the serotonergic system is causally involved in anxiety-related mechanisms and that it may be worth pursuing the role of tryptophan depletion on CO2-induced panic in patients with anxiety disorders.

Publication Types:
Clinical Trial
Randomized Controlled Trial
Original languageEnglish
Pages (from-to)167-174
Number of pages8
JournalPsychiatry Research
Volume77
Issue number3
DOIs
Publication statusPublished - 1 Jan 1998

Cite this

Klaassen, T., Klumperbeek, J., Deutz, N. E. P., van Praag, H. M., & Griez, E. J. L. (1998). Effects of tryptophan depletion on anxiety and on panic provoked by carbon dioxide challenge. Psychiatry Research, 77(3), 167-174. https://doi.org/10.1016/S0165-1781(98)00004-3
Klaassen, T. ; Klumperbeek, J. ; Deutz, N.E.P. ; van Praag, H.M. ; Griez, E.J.L. / Effects of tryptophan depletion on anxiety and on panic provoked by carbon dioxide challenge. In: Psychiatry Research. 1998 ; Vol. 77, No. 3. pp. 167-174.
@article{fed93512ee0d48bf9eca53fcdc92da1c,
title = "Effects of tryptophan depletion on anxiety and on panic provoked by carbon dioxide challenge.",
abstract = "Department of Psychiatry and Neuropsychology, Maastricht University, The Netherlands.Results of several studies suggest that anxiety is under serotonergic control. We studied the influence of tryptophan depletion on generalized anxiety and on the response to a 35{\%} carbon dioxide (CO2) challenge. Fifteen healthy male volunteers received both a mixture of amino acids without tryptophan and a placebo mixture under double-blind conditions. The tryptophan-free mixture led to an 80{\%} decrease in blood tryptophan levels compared to the placebo. There was a significant increase in anxiety on the Spielberger Anxiety Inventory and a trend towards more tension on the Profile of Mood States-'tension' items, both of which were interpreted as increased nervousness. Furthermore, a significant increase in neurovegetative panic symptoms occurred after the CO2 challenge. We conclude that the serotonergic system is causally involved in anxiety-related mechanisms and that it may be worth pursuing the role of tryptophan depletion on CO2-induced panic in patients with anxiety disorders.Publication Types: Clinical Trial Randomized Controlled Trial",
author = "T. Klaassen and J. Klumperbeek and N.E.P. Deutz and {van Praag}, H.M. and E.J.L. Griez",
year = "1998",
month = "1",
day = "1",
doi = "10.1016/S0165-1781(98)00004-3",
language = "English",
volume = "77",
pages = "167--174",
journal = "Psychiatry Research",
issn = "0165-1781",
publisher = "Elsevier Ireland Ltd",
number = "3",

}

Klaassen, T, Klumperbeek, J, Deutz, NEP, van Praag, HM & Griez, EJL 1998, 'Effects of tryptophan depletion on anxiety and on panic provoked by carbon dioxide challenge.', Psychiatry Research, vol. 77, no. 3, pp. 167-174. https://doi.org/10.1016/S0165-1781(98)00004-3

Effects of tryptophan depletion on anxiety and on panic provoked by carbon dioxide challenge. / Klaassen, T.; Klumperbeek, J.; Deutz, N.E.P.; van Praag, H.M.; Griez, E.J.L.

In: Psychiatry Research, Vol. 77, No. 3, 01.01.1998, p. 167-174.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Effects of tryptophan depletion on anxiety and on panic provoked by carbon dioxide challenge.

AU - Klaassen, T.

AU - Klumperbeek, J.

AU - Deutz, N.E.P.

AU - van Praag, H.M.

AU - Griez, E.J.L.

PY - 1998/1/1

Y1 - 1998/1/1

N2 - Department of Psychiatry and Neuropsychology, Maastricht University, The Netherlands.Results of several studies suggest that anxiety is under serotonergic control. We studied the influence of tryptophan depletion on generalized anxiety and on the response to a 35% carbon dioxide (CO2) challenge. Fifteen healthy male volunteers received both a mixture of amino acids without tryptophan and a placebo mixture under double-blind conditions. The tryptophan-free mixture led to an 80% decrease in blood tryptophan levels compared to the placebo. There was a significant increase in anxiety on the Spielberger Anxiety Inventory and a trend towards more tension on the Profile of Mood States-'tension' items, both of which were interpreted as increased nervousness. Furthermore, a significant increase in neurovegetative panic symptoms occurred after the CO2 challenge. We conclude that the serotonergic system is causally involved in anxiety-related mechanisms and that it may be worth pursuing the role of tryptophan depletion on CO2-induced panic in patients with anxiety disorders.Publication Types: Clinical Trial Randomized Controlled Trial

AB - Department of Psychiatry and Neuropsychology, Maastricht University, The Netherlands.Results of several studies suggest that anxiety is under serotonergic control. We studied the influence of tryptophan depletion on generalized anxiety and on the response to a 35% carbon dioxide (CO2) challenge. Fifteen healthy male volunteers received both a mixture of amino acids without tryptophan and a placebo mixture under double-blind conditions. The tryptophan-free mixture led to an 80% decrease in blood tryptophan levels compared to the placebo. There was a significant increase in anxiety on the Spielberger Anxiety Inventory and a trend towards more tension on the Profile of Mood States-'tension' items, both of which were interpreted as increased nervousness. Furthermore, a significant increase in neurovegetative panic symptoms occurred after the CO2 challenge. We conclude that the serotonergic system is causally involved in anxiety-related mechanisms and that it may be worth pursuing the role of tryptophan depletion on CO2-induced panic in patients with anxiety disorders.Publication Types: Clinical Trial Randomized Controlled Trial

U2 - 10.1016/S0165-1781(98)00004-3

DO - 10.1016/S0165-1781(98)00004-3

M3 - Article

VL - 77

SP - 167

EP - 174

JO - Psychiatry Research

JF - Psychiatry Research

SN - 0165-1781

IS - 3

ER -