Effects of some polyene antibiotics on human platelets and their function

P.M. van der Plas; L. Kraan; J. Stibbe; H.C. Hemker

doi:10.1159/000213984

Effects of some polyene antibiotics on human platelets and their function

P.M. van der Plas, L. Kraan, J. Stibbe, H.C. Hemker

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Abstract

(1) Polyenes aggregate platelets. The aggregation power diminishes in the following order: filipin > nystatin > etruscomycin∼pimaricin. (2) In the case of filipin, aggregation is probably caused by damage to platelets resulting in a release of platelet contents, which subsequent aggregates the remaining platelets. (3) Filipin-induced aggregation can be partially inhibited by adenosine and is Ca++-dependent. (4) Collagen- and ADP-induced aggregation can be inhibited by low concentrations of etruscomycin. (5) Polyenes are able to release platelet factor 3 from thrombocytes. The strength decreases in the following order: filipin > nystatin > etruscomycin > pimaricin. (6) The uptake of serotonin by platelets is diminshed by polyenes. Leakage of 86Rb from preloaded platelets increases upon addition of polyenes.

Original language	English
Pages (from-to)	175-190
Number of pages	16
Journal	Haemostasis
Volume	1972/1973
Issue number	3/4
DOIs	https://doi.org/10.1159/000213984
Publication status	Published - 1972

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title = "Effects of some polyene antibiotics on human platelets and their function",

abstract = "(1) Polyenes aggregate platelets. The aggregation power diminishes in the following order: filipin > nystatin > etruscomycin∼pimaricin. (2) In the case of filipin, aggregation is probably caused by damage to platelets resulting in a release of platelet contents, which subsequent aggregates the remaining platelets. (3) Filipin-induced aggregation can be partially inhibited by adenosine and is Ca++-dependent. (4) Collagen- and ADP-induced aggregation can be inhibited by low concentrations of etruscomycin. (5) Polyenes are able to release platelet factor 3 from thrombocytes. The strength decreases in the following order: filipin > nystatin > etruscomycin > pimaricin. (6) The uptake of serotonin by platelets is diminshed by polyenes. Leakage of 86Rb from preloaded platelets increases upon addition of polyenes.",

author = "{van der Plas}, P.M. and L. Kraan and J. Stibbe and H.C. Hemker",

year = "1972",

doi = "10.1159/000213984",

language = "English",

volume = "1972/1973",

pages = "175--190",

journal = "Haemostasis",

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T1 - Effects of some polyene antibiotics on human platelets and their function

AU - van der Plas, P.M.

AU - Kraan, L.

AU - Stibbe, J.

AU - Hemker, H.C.

PY - 1972

Y1 - 1972

N2 - (1) Polyenes aggregate platelets. The aggregation power diminishes in the following order: filipin > nystatin > etruscomycin∼pimaricin. (2) In the case of filipin, aggregation is probably caused by damage to platelets resulting in a release of platelet contents, which subsequent aggregates the remaining platelets. (3) Filipin-induced aggregation can be partially inhibited by adenosine and is Ca++-dependent. (4) Collagen- and ADP-induced aggregation can be inhibited by low concentrations of etruscomycin. (5) Polyenes are able to release platelet factor 3 from thrombocytes. The strength decreases in the following order: filipin > nystatin > etruscomycin > pimaricin. (6) The uptake of serotonin by platelets is diminshed by polyenes. Leakage of 86Rb from preloaded platelets increases upon addition of polyenes.

AB - (1) Polyenes aggregate platelets. The aggregation power diminishes in the following order: filipin > nystatin > etruscomycin∼pimaricin. (2) In the case of filipin, aggregation is probably caused by damage to platelets resulting in a release of platelet contents, which subsequent aggregates the remaining platelets. (3) Filipin-induced aggregation can be partially inhibited by adenosine and is Ca++-dependent. (4) Collagen- and ADP-induced aggregation can be inhibited by low concentrations of etruscomycin. (5) Polyenes are able to release platelet factor 3 from thrombocytes. The strength decreases in the following order: filipin > nystatin > etruscomycin > pimaricin. (6) The uptake of serotonin by platelets is diminshed by polyenes. Leakage of 86Rb from preloaded platelets increases upon addition of polyenes.

U2 - 10.1159/000213984

DO - 10.1159/000213984

M3 - Article

SN - 0301-0147

VL - 1972/1973

SP - 175

EP - 190

JO - Haemostasis

JF - Haemostasis

IS - 3/4

ER -

Effects of some polyene antibiotics on human platelets and their function

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