@article{2a0ced49839848729eef381c2277df29,
title = "Effects of functional pasta ingredients on different gut microbiota as revealed by TIM-2 in vitro model of the proximal colon",
abstract = "Diet-related modulation of gut microbiota and its metabolic activity represents an intriguing research context, particularly in the case of disorders related to imbalances in gut microbial communities. We here explored the effects of Bacillus coagulans GBI-30, 6086 (BC30), β-glucans, and innovative whole-grain pastas, with or without these functional ingredients, on gut microbiota from three groups of children, presenting different susceptibility to type 1 diabetes, by using the well-controlled TNO in vitro model of the proximal colon (TIM-2). Short- and branched-chain fatty acids production and microbiota composition were assessed by means of gas chromatography and 16S rRNA gene profiling, respectively. In most cases, in vitro dietary interventions caused microbiota-dependent modulations as a result of intergroup variability, but also specific changes in microbial groups were shared between the three microbiotas, highlighting specific diet-microbial taxa connections.",
keywords = "6086, BACILLUS-COAGULANS GBI-30, BACTERIA, BETA-GLUCANS, BREAKFAST CEREAL, Bacillus coagulans GBI-30, DIETARY SUPPLEMENTATION, FECAL MICROBIOTA, FERMENTATION, LARGE-INTESTINE, PRODUCTS, SYSTEM, beta-glucans, gut microbiota, type 1 diabetes, whole-grain pastas",
author = "A Martina and Felis, {G E} and M Corradi and C Maffeis and S Torriani and K Venema",
note = "Funding Information: This work was partially funded by the Italian Ministry for Economic Development [grant number MI01_00138] and has been made possible with the support of the Dutch Province of Limburg with a grant to Maastricht University – campus Venlo, Centre for Healthy Eating and Food Innovation, NUTRIM School of Nutrition and Translational Research in Metabolism. AM was supported by a grant of University of Verona in the framework of Bando Cooperint 2015. Funding Information: We thank Carlota Bussolo de Souza from Maastricht University for her technical assistance in performing the SCFA/BCFA analyses. Dr Giovanna Contreas from Unit of Pediatric Diabetes and Metabolic Diseases, Regional Center for Pediatric Diabetes, University of Verona, is gratefully acknowledged for her help in the recruitment phase of the project. The authors would like to thank David Keller and Howard Cash (Ganeden, Mayfield Heights, OH, USA) for providing the freeze-dried preparation of B. coagulans GBI-30, 6086. This work was partially funded by the Italian Ministry for Economic Development [grant number MI01_00138] and has been made possible with the support of the Dutch Province of Limburg with a grant to Maastricht University – campus Venlo, Centre for Healthy Eating and Food Innovation, NUTRIM School of Nutrition and Translational Research in Metabolism. AM was supported by a grant of University of Verona in the framework of Bando Cooperint 2015. Publisher Copyright: {\textcopyright} 2019 Wageningen Academic Publishers.",
year = "2019",
doi = "10.3920/BM2018.0088",
language = "English",
volume = "10",
pages = "301--313",
journal = "Beneficial Microbes",
issn = "1876-2883",
publisher = "Wageningen Academic Publishers",
number = "3",
}