Effects of diet-induced weight loss on postprandial vascular function after consumption of a mixed meal: Results of a randomized controlled trial with abdominally obese men

Peter J. Joris; Jogchum Plat; Yvo H. A. M. Kusters; Alfons J. H. M. Houben; Coen D. A. Stehouwer; Casper G. Schalkwijk; Ronald P. Mensink

doi:10.1016/j.clnu.2020.01.006

Effects of diet-induced weight loss on postprandial vascular function after consumption of a mixed meal: Results of a randomized controlled trial with abdominally obese men

Peter J. Joris^*, Jogchum Plat, Yvo H. A. M. Kusters, Alfons J. H. M. Houben, Coen D. A. Stehouwer, Casper G. Schalkwijk, Ronald P. Mensink

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Background: Effects of weight loss on postprandial vascular function have not been studied so far. We therefore examined (i) effects of diet-induced weight loss on postprandial changes in various vascular function markers after consumption of a mixed meal and (ii) differences between normal-weight and abdominally obese men of comparable age at baseline and after weight loss.

Methods: Fifty-four apparently healthy abdominally obese (waist circumference: 102-110 cm) and 25 normal-weight men (waist circumference:

Results: The mean weight loss was 10.3 kg in the weight-loss compared with the control group. The postprandial change in flow-mediated vasodilation of the brachial artery (FMD) was significantly higher at baseline in normal-weight as compared with the postprandial change in abdominally obese men (1.89 +/- 2.52 versus 0.48 +/- 2.50 percentage points; P = 0.027). However, no differences in postprandial changes were observed in the abdominally obese men after weight loss compared with the control treatment. Also, weight reduction did not affect postprandial changes in carotid-to-femoral pulse wave velocity, retinal microvascular caliber properties, or plasma markers of microvascular endothelial function. Even though postprandial increases in triacylglycerol (P = 0.028), insulin (P = 0.029) and C-peptide concentrations (P <0.001) were reduced in the abdominally obese men following weight loss, postprandial changes in FMD at the end of the weight-loss treatment were still more unfavorable as compared with those observed in normal-weight individuals.

Conclusion: In this trial with abdominally obese men, we did not find effects of diet-induced weight loss on postprandial changes in vascular endothelial function, arterial stiffness and markers of microvascular function. (C) 2020 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

Original language	English
Pages (from-to)	2998-3004
Number of pages	7
Journal	Clinical Nutrition
Volume	39
Issue number	10
DOIs	https://doi.org/10.1016/j.clnu.2020.01.006
Publication status	Published - Oct 2020

Keywords

Human trials
Weight loss
Postprandial
Vascular function
Abdominal obesity
ENDOTHELIUM-DEPENDENT VASODILATION
HIGH-FAT MEAL
FLOW-MEDIATED VASODILATION
EXPERT CONSENSUS DOCUMENT
BRACHIAL-ARTERY
BLOOD-PRESSURE
DYSFUNCTION
STIFFNESS
IMPROVES
MARKERS

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Joris, P. J., Plat, J., Kusters, Y. H. A. M., Houben, A. J. H. M., Stehouwer, C. D. A., Schalkwijk, C. G., & Mensink, R. P. (2020). Effects of diet-induced weight loss on postprandial vascular function after consumption of a mixed meal: Results of a randomized controlled trial with abdominally obese men. Clinical Nutrition, 39(10), 2998-3004. https://doi.org/10.1016/j.clnu.2020.01.006

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title = "Effects of diet-induced weight loss on postprandial vascular function after consumption of a mixed meal: Results of a randomized controlled trial with abdominally obese men",

abstract = "Background: Effects of weight loss on postprandial vascular function have not been studied so far. We therefore examined (i) effects of diet-induced weight loss on postprandial changes in various vascular function markers after consumption of a mixed meal and (ii) differences between normal-weight and abdominally obese men of comparable age at baseline and after weight loss.Methods: Fifty-four apparently healthy abdominally obese (waist circumference: 102-110 cm) and 25 normal-weight men (waist circumference:Results: The mean weight loss was 10.3 kg in the weight-loss compared with the control group. The postprandial change in flow-mediated vasodilation of the brachial artery (FMD) was significantly higher at baseline in normal-weight as compared with the postprandial change in abdominally obese men (1.89 +/- 2.52 versus 0.48 +/- 2.50 percentage points; P = 0.027). However, no differences in postprandial changes were observed in the abdominally obese men after weight loss compared with the control treatment. Also, weight reduction did not affect postprandial changes in carotid-to-femoral pulse wave velocity, retinal microvascular caliber properties, or plasma markers of microvascular endothelial function. Even though postprandial increases in triacylglycerol (P = 0.028), insulin (P = 0.029) and C-peptide concentrations (P <0.001) were reduced in the abdominally obese men following weight loss, postprandial changes in FMD at the end of the weight-loss treatment were still more unfavorable as compared with those observed in normal-weight individuals.Conclusion: In this trial with abdominally obese men, we did not find effects of diet-induced weight loss on postprandial changes in vascular endothelial function, arterial stiffness and markers of microvascular function. (C) 2020 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.",

keywords = "Human trials, Weight loss, Postprandial, Vascular function, Abdominal obesity, ENDOTHELIUM-DEPENDENT VASODILATION, HIGH-FAT MEAL, FLOW-MEDIATED VASODILATION, EXPERT CONSENSUS DOCUMENT, BRACHIAL-ARTERY, BLOOD-PRESSURE, DYSFUNCTION, STIFFNESS, IMPROVES, MARKERS",

author = "Joris, {Peter J.} and Jogchum Plat and Kusters, {Yvo H. A. M.} and Houben, {Alfons J. H. M.} and Stehouwer, {Coen D. A.} and Schalkwijk, {Casper G.} and Mensink, {Ronald P.}",

year = "2020",

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doi = "10.1016/j.clnu.2020.01.006",

language = "English",

volume = "39",

pages = "2998--3004",

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issn = "0261-5614",

publisher = "Churchill Livingstone",

number = "10",

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Joris, PJ , Plat, J, Kusters, YHAM, Houben, AJHM , Stehouwer, CDA , Schalkwijk, CG & Mensink, RP 2020, 'Effects of diet-induced weight loss on postprandial vascular function after consumption of a mixed meal: Results of a randomized controlled trial with abdominally obese men', Clinical Nutrition, vol. 39, no. 10, pp. 2998-3004. https://doi.org/10.1016/j.clnu.2020.01.006

Effects of diet-induced weight loss on postprandial vascular function after consumption of a mixed meal: Results of a randomized controlled trial with abdominally obese men. / Joris, Peter J.; Plat, Jogchum; Kusters, Yvo H. A. M. et al.
In: Clinical Nutrition, Vol. 39, No. 10, 10.2020, p. 2998-3004.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Effects of diet-induced weight loss on postprandial vascular function after consumption of a mixed meal

T2 - Results of a randomized controlled trial with abdominally obese men

AU - Joris, Peter J.

AU - Plat, Jogchum

AU - Kusters, Yvo H. A. M.

AU - Houben, Alfons J. H. M.

AU - Stehouwer, Coen D. A.

AU - Schalkwijk, Casper G.

AU - Mensink, Ronald P.

PY - 2020/10

Y1 - 2020/10

N2 - Background: Effects of weight loss on postprandial vascular function have not been studied so far. We therefore examined (i) effects of diet-induced weight loss on postprandial changes in various vascular function markers after consumption of a mixed meal and (ii) differences between normal-weight and abdominally obese men of comparable age at baseline and after weight loss.Methods: Fifty-four apparently healthy abdominally obese (waist circumference: 102-110 cm) and 25 normal-weight men (waist circumference:Results: The mean weight loss was 10.3 kg in the weight-loss compared with the control group. The postprandial change in flow-mediated vasodilation of the brachial artery (FMD) was significantly higher at baseline in normal-weight as compared with the postprandial change in abdominally obese men (1.89 +/- 2.52 versus 0.48 +/- 2.50 percentage points; P = 0.027). However, no differences in postprandial changes were observed in the abdominally obese men after weight loss compared with the control treatment. Also, weight reduction did not affect postprandial changes in carotid-to-femoral pulse wave velocity, retinal microvascular caliber properties, or plasma markers of microvascular endothelial function. Even though postprandial increases in triacylglycerol (P = 0.028), insulin (P = 0.029) and C-peptide concentrations (P <0.001) were reduced in the abdominally obese men following weight loss, postprandial changes in FMD at the end of the weight-loss treatment were still more unfavorable as compared with those observed in normal-weight individuals.Conclusion: In this trial with abdominally obese men, we did not find effects of diet-induced weight loss on postprandial changes in vascular endothelial function, arterial stiffness and markers of microvascular function. (C) 2020 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

AB - Background: Effects of weight loss on postprandial vascular function have not been studied so far. We therefore examined (i) effects of diet-induced weight loss on postprandial changes in various vascular function markers after consumption of a mixed meal and (ii) differences between normal-weight and abdominally obese men of comparable age at baseline and after weight loss.Methods: Fifty-four apparently healthy abdominally obese (waist circumference: 102-110 cm) and 25 normal-weight men (waist circumference:Results: The mean weight loss was 10.3 kg in the weight-loss compared with the control group. The postprandial change in flow-mediated vasodilation of the brachial artery (FMD) was significantly higher at baseline in normal-weight as compared with the postprandial change in abdominally obese men (1.89 +/- 2.52 versus 0.48 +/- 2.50 percentage points; P = 0.027). However, no differences in postprandial changes were observed in the abdominally obese men after weight loss compared with the control treatment. Also, weight reduction did not affect postprandial changes in carotid-to-femoral pulse wave velocity, retinal microvascular caliber properties, or plasma markers of microvascular endothelial function. Even though postprandial increases in triacylglycerol (P = 0.028), insulin (P = 0.029) and C-peptide concentrations (P <0.001) were reduced in the abdominally obese men following weight loss, postprandial changes in FMD at the end of the weight-loss treatment were still more unfavorable as compared with those observed in normal-weight individuals.Conclusion: In this trial with abdominally obese men, we did not find effects of diet-induced weight loss on postprandial changes in vascular endothelial function, arterial stiffness and markers of microvascular function. (C) 2020 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

KW - Human trials

KW - Weight loss

KW - Postprandial

KW - Vascular function

KW - Abdominal obesity

KW - ENDOTHELIUM-DEPENDENT VASODILATION

KW - HIGH-FAT MEAL

KW - FLOW-MEDIATED VASODILATION

KW - EXPERT CONSENSUS DOCUMENT

KW - BRACHIAL-ARTERY

KW - BLOOD-PRESSURE

KW - DYSFUNCTION

KW - STIFFNESS

KW - IMPROVES

KW - MARKERS

U2 - 10.1016/j.clnu.2020.01.006

DO - 10.1016/j.clnu.2020.01.006

M3 - Article

C2 - 31982191

SN - 0261-5614

VL - 39

SP - 2998

EP - 3004

JO - Clinical Nutrition

JF - Clinical Nutrition

IS - 10

ER -