Abstract
Aims/hypothesis Endothelial glycocalyx perturbation contributes to increased vascular permeability. In the present study we set out to evaluate whether: (1) glycocalyx is perturbed in individuals with type 2 diabetes mellitus, and (2) oral glycocalyx precursor treatment improves glycocalyx properties. Methods Male participants with type 2 diabetes (n=10) and controls (n=10) were evaluated before and after 2 months of sulodexide administration (200 mg/day). The glycocalyx dimension was estimated in two different vascular beds using sidestream dark field imaging and combined fluorescein/indocyanine green angiography for sublingual and retinal vessels, respectively. Transcapillary escape rate of albumin (TERalb) and hyaluronan catabolism were assessed as measures of vascular permeability. Results Both sublingual dimensions (0.64 [0.57-0.75] mu m vs 0.78 [0.71-0.85] mu m, p
Original language | English |
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Pages (from-to) | 2646-2655 |
Journal | Diabetologia |
Volume | 53 |
Issue number | 12 |
DOIs | |
Publication status | Published - Dec 2010 |
Keywords
- Diabetes mellitus type 2
- Endothelial glycocalyx
- Hyaluronan
- Sulodexide
- Vascular permeability