Effect of sulodexide on endothelial glycocalyx and vascular permeability in patients with type 2 diabetes mellitus

Lysette N. Broekhuizen, Bregtje A. Lemkes, H. L. Mooij, M. C. Meuwese, H.J. Verberne, F. Holleman, Reinier O. Schlingemann, M. Nieuwdorp, Erik S. G. Stroes*, H. Vink

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

215 Citations (Web of Science)

Abstract

Aims/hypothesis Endothelial glycocalyx perturbation contributes to increased vascular permeability. In the present study we set out to evaluate whether: (1) glycocalyx is perturbed in individuals with type 2 diabetes mellitus, and (2) oral glycocalyx precursor treatment improves glycocalyx properties. Methods Male participants with type 2 diabetes (n=10) and controls (n=10) were evaluated before and after 2 months of sulodexide administration (200 mg/day). The glycocalyx dimension was estimated in two different vascular beds using sidestream dark field imaging and combined fluorescein/indocyanine green angiography for sublingual and retinal vessels, respectively. Transcapillary escape rate of albumin (TERalb) and hyaluronan catabolism were assessed as measures of vascular permeability. Results Both sublingual dimensions (0.64 [0.57-0.75] mu m vs 0.78 [0.71-0.85] mu m, p
Original languageEnglish
Pages (from-to)2646-2655
JournalDiabetologia
Volume53
Issue number12
DOIs
Publication statusPublished - Dec 2010

Keywords

  • Diabetes mellitus type 2
  • Endothelial glycocalyx
  • Hyaluronan
  • Sulodexide
  • Vascular permeability

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