Effect of personalized nutrition on health-related behaviour change: evidence from the Food4Me European randomized controlled trial

Carlos Celis-Morales, Katherine M. Livingstone, Cyril F. M. Marsaux, Anna L. Macready, Rosalind Fallaize, Clare B. O'Donovan, Clara Woolhead, Hannah Forster, Marianne C. Walsh, Santiago Navas-Carretero, Rodrigo San-Cristobal, Lydia Tsirigoti, Christina P. Lambrinou, Christina Mavrogianni, George Moschonis, Silvia Kolossa, Jacqueline Hallmann, Magdalena Godlewska, Agnieszka Surwillo, Iwona TraczykChristian A. Drevon, Jildau Bouwman, Ben van Ommen, Keith Grimaldi, Laurence D. Parnell, John N. S. Matthews, Yannis Manios, Hannelore Daniel, J. AlfredoMartinez, Julie A. Lovegrove, Eileen R. Gibney, Lorraine Brennan, Wim H. M. Saris, Mike Gibney, John C. Mathers*, FoodMe Study

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

168 Citations (Web of Science)

Abstract

Background: Optimal nutritional choices are linked with better health, but many current interventions to improve diet have limited effect. We tested the hypothesis that providing personalized nutrition (PN) advice based on information on individual diet and lifestyle, phenotype and/or genotype would promote larger, more appropriate, and sustained changes in dietary behaviour.

Methods: Adults from seven European countries were recruited to an internet-delivered intervention (Food4Me) and randomized to: (i) conventional dietary advice (control) or to PN advice based on: (ii) individual baseline diet; (iii) individual baseline diet plus phenotype (anthropometry and blood biomarkers); or (iv) individual baseline diet plus phenotype plus genotype (five diet-responsive genetic variants). Outcomes were dietary intake, anthropometry and blood biomarkers measured at baseline and after 3 and 6 months' intervention.

Results: At baseline, mean age of participants was 39.8 years (range 18-79), 59% of participants were female and mean body mass index (BMI) was 25.5 kg/m(2). From the enrolled participants, 1269 completed the study. Following a 6-month intervention, participants randomized to PN consumed less red meat [-5.48 g, (95% confidence interval:-10.8,-0.09), P = 0.046], salt [-0.65 g, (-1.1,-0.25), P = 0.002] and saturated fat [-1.14 % of energy, (-1.6,-0.67), P

Conclusions: Among European adults, PN advice via internet-delivered intervention produced larger and more appropriate changes in dietary behaviour than a conventional approach.

Original languageEnglish
Pages (from-to)578-588
Number of pages11
JournalInternational Journal of Epidemiology
Volume46
Issue number2
DOIs
Publication statusPublished - Apr 2017

Keywords

  • Personalized nutrition
  • internet-based
  • randomized controlled trial
  • genotype
  • phenotype
  • obesity
  • diet
  • metabolic health
  • NONCOMMUNICABLE DISEASES
  • QUESTIONNAIRE
  • RESPONSES
  • INDEX
  • WEB

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