TY - JOUR
T1 - Effect of growth hormone treatment on energy expenditure and its relation to first-year growth response in children
AU - Straetemans, Saartje
AU - Schott, D. A.
AU - Plasqui, Guy
AU - Dotremont, Hilde
AU - Gerver-Jansen, Angele J. G. M.
AU - Verrijken, An
AU - Westerterp, Klaas
AU - Zimmermann, Luc J. I.
AU - Gerver, Willem-Jan M.
N1 - Funding Information:
received funding from Pfizer, no other conflicts of
Funding Information:
We would like to thank Prof. Dr. L. Van Gaal for providing the ventilated hood equipment at the metabolic unit, department Endocrinology, Diabetology and Metabolic Diseases of the Antwerp University Hospital; Loek Wouters for analyses of the ventilated hood and doubly labeled water methods; Dr. M. Den Brinker and Dr. A. France for the enrollment of patients at the Antwerp University Hospital.
Publisher Copyright:
© 2018, The Author(s).
PY - 2019/2
Y1 - 2019/2
N2 - PurposeThe effects of growth hormone (GH) treatment on linear growth and body composition have been studied extensively. Little is known about the GH effect on energy expenditure (EE). The aim of this study was to investigate the effects of GH treatment on EE in children, and to study whether the changes in EE can predict the height gain after 1year.MethodsTotal EE (TEE), basal metabolic rate (BMR), and physical activity level (PAL) measurements before and after 6 weeks of GH treatment were performed in 18 prepubertal children (5 girls, 13 boys) born small for gestational age (n=14) or with growth hormone deficiency (n=4) who were eligible for GH treatment. TEE was measured with the doubly labelled water method, BMR was measured with an open-circuit ventilated hood system, PAL was assessed using an accelerometer for movement registration and calculated (PAL=TEE/BMR), activity related EE (AEE) was calculated [AEE=(0.9xTEE)-BMR]. Height measurements at start and after 1year of GH treatment were analysed. This is a 1-year longitudinal intervention study, without a control group for comparison.ResultsBMR and TEE increased significantly (resp. 5% and 7%). Physical activity (counts/day), PAL, and AEE did not change. 11 out of 13 patients (85%) with an increased TEE after 6 weeks of GH treatment had a good first-year growth response (height SDS>0.5).ConclusionsGH treatment showed a positive effect on EE in prepubertal children after 6 weeks. No effect on physical activity was observed. The increase in TEE appeared to be valuable for the prediction of good first-year growth responders to GH treatment.
AB - PurposeThe effects of growth hormone (GH) treatment on linear growth and body composition have been studied extensively. Little is known about the GH effect on energy expenditure (EE). The aim of this study was to investigate the effects of GH treatment on EE in children, and to study whether the changes in EE can predict the height gain after 1year.MethodsTotal EE (TEE), basal metabolic rate (BMR), and physical activity level (PAL) measurements before and after 6 weeks of GH treatment were performed in 18 prepubertal children (5 girls, 13 boys) born small for gestational age (n=14) or with growth hormone deficiency (n=4) who were eligible for GH treatment. TEE was measured with the doubly labelled water method, BMR was measured with an open-circuit ventilated hood system, PAL was assessed using an accelerometer for movement registration and calculated (PAL=TEE/BMR), activity related EE (AEE) was calculated [AEE=(0.9xTEE)-BMR]. Height measurements at start and after 1year of GH treatment were analysed. This is a 1-year longitudinal intervention study, without a control group for comparison.ResultsBMR and TEE increased significantly (resp. 5% and 7%). Physical activity (counts/day), PAL, and AEE did not change. 11 out of 13 patients (85%) with an increased TEE after 6 weeks of GH treatment had a good first-year growth response (height SDS>0.5).ConclusionsGH treatment showed a positive effect on EE in prepubertal children after 6 weeks. No effect on physical activity was observed. The increase in TEE appeared to be valuable for the prediction of good first-year growth responders to GH treatment.
KW - Energy expenditure
KW - Body composition
KW - Metabolism
KW - Growth hormone treatment
KW - Children
KW - First-year growth response
KW - DOUBLY-LABELED WATER
KW - BASAL METABOLIC-RATE
KW - BODY-COMPOSITION
KW - PHYSICAL-ACTIVITY
KW - SUBSTRATE METABOLISM
KW - THYROID-FUNCTION
KW - FUEL METABOLISM
KW - GESTATIONAL-AGE
KW - ACCELEROMETRY
KW - PREDICTOR
U2 - 10.1007/s00421-018-4033-6
DO - 10.1007/s00421-018-4033-6
M3 - Article
C2 - 30478629
SN - 1439-6319
VL - 119
SP - 409
EP - 418
JO - European Journal of Applied Physiology
JF - European Journal of Applied Physiology
IS - 2
ER -