Abstract
Dietary recommendations to lower cardiovascular disease (CVD) risk are focused on reducing the intake of dietary saturated fatty acids (SFAs). However, the number of randomized controlled trials (RCTs) with cardiovascular events as endpoints is still limited, which makes it difficult to define the most optimal substitute for the dietary SFAs. The effects of dietary fatty acid intake on cardiovascular risk markers, such as serum lipid and lipoprotein cholesterol concentrations and noninvasive vascular function markers, can then be studied as an alternative approach. This chapter first summarizes the relation between these lipid-sensitive markers and cardiovascular risk. Then, intervention effects of dietary fatty acids on cardiovascular risk markers and on CVD events as endpoints are discussed. For this, the focus will primarily be on human RCTs.
Original language | English |
---|---|
Title of host publication | Functional Dietary Lipids: Food Formulation, Consumer Issues, and Innovation for Health, Second Edition |
Publisher | Elsevier |
Pages | 169-185 |
Number of pages | 17 |
Volume | 1 |
Edition | 2 |
ISBN (Electronic) | 9780443153273 |
ISBN (Print) | 9780443153280 |
DOIs | |
Publication status | Published - 1 Jan 2023 |
Keywords
- Cardiovascular disease
- Dietary fatty acids
- Randomized controlled trials
- Risk markers
- Serum lipids and lipoproteins
- Vascular function