Effect of beta-adrenergic stimulation on whole-body and abdominal subcutaneous adipose tissue lipolysis in lean and obese men.

J.W. Jocken, G.H. Goossens, A.M.J. van Hees, K.N. Frayn, M.A. van Baak, J.H.C.H. Stegen, M.T. Pakbiers, W.H. Saris, E.E. Blaak

    Research output: Contribution to journalArticleAcademicpeer-review

    36 Citations (Scopus)

    Abstract

    Aims/hypiothesis Obesity is characterised by increased triacylglycerol storage in adipose tissue. There is in vitro evidence for a blunted beta-adrenergically mediated lipolytic response in abdominal subcutaneous adipose tissue (SAT) of obese individuals and evidence for this at the whole-body level in vivo. We hypothesised that the beta-adrenergically mediated effect on lipolysis in abdominal SAT is also impaired in vivo in obese humans. Methods We investigated whole-body and abdominal SAT glycerol metabolism in vivo during 3 h and 6 h [H-2(5)]glycerol infusions. Arterio-venous concentration differences were measured in 13 lean and ten obese men after an overnight fast and during intravenous infusion of the non-selective beta-adrenergic agonist isoprenaline [20 ng (kg fat free mass)(-1)min(-1)]. Results Lean and obese participants showed comparable fasting glycerol uptake by SAT (9.7 +/- 3.4 vs 9.3 +/- 2.5% of total release, p=0.92). Furthermore, obese participants showed an increased whole-body beta-adrenergically mediated lipolytic response versus lean participants. However, their fasting lipolysis was blunted [glycerol rate of appearance: 7.3 +/- 0.6 vs 13.1 +/- 0.9 mu mol (kg fat mass)(-1)min(-1), p
    Original languageEnglish
    Pages (from-to)320-327
    JournalDiabetologia
    Volume51
    Issue number2
    DOIs
    Publication statusPublished - 1 Jan 2008

    Cite this