Echo/Doppler-derived time intervals are able to predict left ventricular reverse remodeling after cardiac resynchronization therapy

Cristina M. Porciani; Alessio Lilli; Francesco Cappelli; Alessia Pappone; Alessandro Paoletti Perini; Paolo Pieragnoli; Giuseppe Ricciardi; Carmelo Massimiliano Rao; Frits W. Prinzen; Antonio Michelucci; Luigi Padeletti

doi:10.2459/JCM.0b013e328332e938

Echo/Doppler-derived time intervals are able to predict left ventricular reverse remodeling after cardiac resynchronization therapy

Cristina M. Porciani, Alessio Lilli^*, Francesco Cappelli, Alessia Pappone, Alessandro Paoletti Perini, Paolo Pieragnoli, Giuseppe Ricciardi, Carmelo Massimiliano Rao, Frits W. Prinzen, Antonio Michelucci, Luigi Padeletti

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

5 Citations (Web of Science)

Abstract

Aim We evaluated the predictive value of echo/Doppler derived indices, which reflect the duration of the isovolumic phases of the cardiac cycle, in identifying cardiac resynchronization therapy (CRT) responders. Methods and results In 105 patients before and 6 months after CRT the following echo/Doppler parameters were evaluated: myocardial performance index (MPI) as the sum of isovolumic contraction time (IVCT) and isovolumic relaxation time (IVRT) divided by ejection time; total isovolumic time (t-IVT) as the sum of IVCT and IVRT divided by the RR interval; and standard deviation of the time to systolic peak velocity (Ts-SD) as asynchrony index. After 6 months, patients were defined responders according to 15% left ventricle (LV) end-systolic volume reduction or more. At baseline, responders (53.3%) had higher t-IVT and MPI than nonresponders (0.30 +/- 0.06 versus 0.22 +/- 0.05, P

Original language	English
Pages (from-to)	157-163
Journal	Journal of Cardiovascular Medicine
Volume	11
Issue number	3
DOIs	https://doi.org/10.2459/JCM.0b013e328332e938
Publication status	Published - Mar 2010

Keywords

cardiac resynchronization therapy
isovolumic time
reverse remodeling

Access to Document

10.2459/JCM.0b013e328332e938

Cite this

Porciani, C. M., Lilli, A., Cappelli, F., Pappone, A., Perini, A. P., Pieragnoli, P., Ricciardi, G., Rao, C. M., Prinzen, F. W., Michelucci, A., & Padeletti, L. (2010). Echo/Doppler-derived time intervals are able to predict left ventricular reverse remodeling after cardiac resynchronization therapy. Journal of Cardiovascular Medicine, 11(3), 157-163. https://doi.org/10.2459/JCM.0b013e328332e938

@article{7c3f0aad79e643459faca346e5105033,

title = "Echo/Doppler-derived time intervals are able to predict left ventricular reverse remodeling after cardiac resynchronization therapy",

abstract = "Aim We evaluated the predictive value of echo/Doppler derived indices, which reflect the duration of the isovolumic phases of the cardiac cycle, in identifying cardiac resynchronization therapy (CRT) responders. Methods and results In 105 patients before and 6 months after CRT the following echo/Doppler parameters were evaluated: myocardial performance index (MPI) as the sum of isovolumic contraction time (IVCT) and isovolumic relaxation time (IVRT) divided by ejection time; total isovolumic time (t-IVT) as the sum of IVCT and IVRT divided by the RR interval; and standard deviation of the time to systolic peak velocity (Ts-SD) as asynchrony index. After 6 months, patients were defined responders according to 15% left ventricle (LV) end-systolic volume reduction or more. At baseline, responders (53.3%) had higher t-IVT and MPI than nonresponders (0.30 +/- 0.06 versus 0.22 +/- 0.05, P",

keywords = "cardiac resynchronization therapy, isovolumic time, reverse remodeling",

author = "Porciani, {Cristina M.} and Alessio Lilli and Francesco Cappelli and Alessia Pappone and Perini, {Alessandro Paoletti} and Paolo Pieragnoli and Giuseppe Ricciardi and Rao, {Carmelo Massimiliano} and Prinzen, {Frits W.} and Antonio Michelucci and Luigi Padeletti",

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doi = "10.2459/JCM.0b013e328332e938",

language = "English",

volume = "11",

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Porciani, CM, Lilli, A, Cappelli, F, Pappone, A, Perini, AP, Pieragnoli, P, Ricciardi, G, Rao, CM, Prinzen, FW, Michelucci, A & Padeletti, L 2010, 'Echo/Doppler-derived time intervals are able to predict left ventricular reverse remodeling after cardiac resynchronization therapy', Journal of Cardiovascular Medicine, vol. 11, no. 3, pp. 157-163. https://doi.org/10.2459/JCM.0b013e328332e938

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T1 - Echo/Doppler-derived time intervals are able to predict left ventricular reverse remodeling after cardiac resynchronization therapy

AU - Porciani, Cristina M.

AU - Lilli, Alessio

AU - Cappelli, Francesco

AU - Pappone, Alessia

AU - Perini, Alessandro Paoletti

AU - Pieragnoli, Paolo

AU - Ricciardi, Giuseppe

AU - Rao, Carmelo Massimiliano

AU - Prinzen, Frits W.

AU - Michelucci, Antonio

AU - Padeletti, Luigi

PY - 2010/3

Y1 - 2010/3

N2 - Aim We evaluated the predictive value of echo/Doppler derived indices, which reflect the duration of the isovolumic phases of the cardiac cycle, in identifying cardiac resynchronization therapy (CRT) responders. Methods and results In 105 patients before and 6 months after CRT the following echo/Doppler parameters were evaluated: myocardial performance index (MPI) as the sum of isovolumic contraction time (IVCT) and isovolumic relaxation time (IVRT) divided by ejection time; total isovolumic time (t-IVT) as the sum of IVCT and IVRT divided by the RR interval; and standard deviation of the time to systolic peak velocity (Ts-SD) as asynchrony index. After 6 months, patients were defined responders according to 15% left ventricle (LV) end-systolic volume reduction or more. At baseline, responders (53.3%) had higher t-IVT and MPI than nonresponders (0.30 +/- 0.06 versus 0.22 +/- 0.05, P

AB - Aim We evaluated the predictive value of echo/Doppler derived indices, which reflect the duration of the isovolumic phases of the cardiac cycle, in identifying cardiac resynchronization therapy (CRT) responders. Methods and results In 105 patients before and 6 months after CRT the following echo/Doppler parameters were evaluated: myocardial performance index (MPI) as the sum of isovolumic contraction time (IVCT) and isovolumic relaxation time (IVRT) divided by ejection time; total isovolumic time (t-IVT) as the sum of IVCT and IVRT divided by the RR interval; and standard deviation of the time to systolic peak velocity (Ts-SD) as asynchrony index. After 6 months, patients were defined responders according to 15% left ventricle (LV) end-systolic volume reduction or more. At baseline, responders (53.3%) had higher t-IVT and MPI than nonresponders (0.30 +/- 0.06 versus 0.22 +/- 0.05, P

KW - cardiac resynchronization therapy

KW - isovolumic time

KW - reverse remodeling

U2 - 10.2459/JCM.0b013e328332e938

DO - 10.2459/JCM.0b013e328332e938

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JO - Journal of Cardiovascular Medicine

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