TY - JOUR
T1 - Echo/Doppler-derived time intervals are able to predict left ventricular reverse remodeling after cardiac resynchronization therapy
AU - Porciani, Cristina M.
AU - Lilli, Alessio
AU - Cappelli, Francesco
AU - Pappone, Alessia
AU - Perini, Alessandro Paoletti
AU - Pieragnoli, Paolo
AU - Ricciardi, Giuseppe
AU - Rao, Carmelo Massimiliano
AU - Prinzen, Frits W.
AU - Michelucci, Antonio
AU - Padeletti, Luigi
PY - 2010/3
Y1 - 2010/3
N2 - Aim We evaluated the predictive value of echo/Doppler derived indices, which reflect the duration of the isovolumic phases of the cardiac cycle, in identifying cardiac resynchronization therapy (CRT) responders. Methods and results In 105 patients before and 6 months after CRT the following echo/Doppler parameters were evaluated: myocardial performance index (MPI) as the sum of isovolumic contraction time (IVCT) and isovolumic relaxation time (IVRT) divided by ejection time; total isovolumic time (t-IVT) as the sum of IVCT and IVRT divided by the RR interval; and standard deviation of the time to systolic peak velocity (Ts-SD) as asynchrony index. After 6 months, patients were defined responders according to 15% left ventricle (LV) end-systolic volume reduction or more. At baseline, responders (53.3%) had higher t-IVT and MPI than nonresponders (0.30 +/- 0.06 versus 0.22 +/- 0.05, P
AB - Aim We evaluated the predictive value of echo/Doppler derived indices, which reflect the duration of the isovolumic phases of the cardiac cycle, in identifying cardiac resynchronization therapy (CRT) responders. Methods and results In 105 patients before and 6 months after CRT the following echo/Doppler parameters were evaluated: myocardial performance index (MPI) as the sum of isovolumic contraction time (IVCT) and isovolumic relaxation time (IVRT) divided by ejection time; total isovolumic time (t-IVT) as the sum of IVCT and IVRT divided by the RR interval; and standard deviation of the time to systolic peak velocity (Ts-SD) as asynchrony index. After 6 months, patients were defined responders according to 15% left ventricle (LV) end-systolic volume reduction or more. At baseline, responders (53.3%) had higher t-IVT and MPI than nonresponders (0.30 +/- 0.06 versus 0.22 +/- 0.05, P
KW - cardiac resynchronization therapy
KW - isovolumic time
KW - reverse remodeling
U2 - 10.2459/JCM.0b013e328332e938
DO - 10.2459/JCM.0b013e328332e938
M3 - Article
C2 - 19841591
SN - 1558-2027
VL - 11
SP - 157
EP - 163
JO - Journal of Cardiovascular Medicine
JF - Journal of Cardiovascular Medicine
IS - 3
ER -