Echo/Doppler-derived time intervals are able to predict left ventricular reverse remodeling after cardiac resynchronization therapy

Cristina M. Porciani, Alessio Lilli*, Francesco Cappelli, Alessia Pappone, Alessandro Paoletti Perini, Paolo Pieragnoli, Giuseppe Ricciardi, Carmelo Massimiliano Rao, Frits W. Prinzen, Antonio Michelucci, Luigi Padeletti

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Aim We evaluated the predictive value of echo/Doppler derived indices, which reflect the duration of the isovolumic phases of the cardiac cycle, in identifying cardiac resynchronization therapy (CRT) responders. Methods and results In 105 patients before and 6 months after CRT the following echo/Doppler parameters were evaluated: myocardial performance index (MPI) as the sum of isovolumic contraction time (IVCT) and isovolumic relaxation time (IVRT) divided by ejection time; total isovolumic time (t-IVT) as the sum of IVCT and IVRT divided by the RR interval; and standard deviation of the time to systolic peak velocity (Ts-SD) as asynchrony index. After 6 months, patients were defined responders according to 15% left ventricle (LV) end-systolic volume reduction or more. At baseline, responders (53.3%) had higher t-IVT and MPI than nonresponders (0.30 +/- 0.06 versus 0.22 +/- 0.05, P
Original languageEnglish
Pages (from-to)157-163
JournalJournal of Cardiovascular Medicine
Issue number3
Publication statusPublished - Mar 2010


  • cardiac resynchronization therapy
  • isovolumic time
  • reverse remodeling

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