Early body weight loss during concurrent chemo-radiotherapy for non-small cell lung cancer

C.M.H. Op den Kamp, D.K.M. de Ruysscher, M. van den Heuvel, M. Elferink, R.M.A. Houben, C.J.G. Oberije, G.P. Bootsma, W.H. Geraedts, C.C.M. Pitz, R.C. Langen, E.F.M. Wouters, A.M.W.J. Schols, A.M.C. Dingemans

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

BACKGROUND AND PURPOSE: Radiation-esophagitis and weight loss are observed toxicities in patients treated with concurrent chemo- (CT-RT) for non-small cell lung cancer (NSCLC) and might be related. The was to investigate whether weight loss already starts early after CT-RT and precedes radiation-esophagitis. MATERIALS AND METHODS: In a retrospective cohort, weight and esophagitis grade >/=2 were assessed first weeks of (CT-)RT in patients treated with concurrent (n = 102) or sequential (n = 92) therapy. In a prospective validation study, data on weight, esophagitis grade >/=2, nutritional intake and muscle strength obtained before, during and following CT-RT. RESULTS: In the cohort, early weight loss was observed in concurrently treated patients 0.002), independent of esophagitis >/= grade 2. Early weight loss was observed in the prospective cohort (p = 0.003) and was not accompanied decreases in nutritional intake. In addition lower limb muscle strength declined (p = 0.042). In the later weeks of treatment, further body occurred (p < 0.001) despite increased nutritional supplementation and weight was only partly recovered after 4 weeks post CT-RT (p = 0.003). CONCLUSIONS: Weight loss during concurrent CT-RT for NSCLC starts early to onset of esophagitis, requiring timely and intense nutritional
Original languageEnglish
Pages (from-to)127-137
JournalJournal of cachexia, sarcopenia and muscle
Volume5
Issue number2
DOIs
Publication statusPublished - 1 Jan 2014

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