Early and intensive motor training to enhance neurological recovery in people with spinal cord injury: trial protocol

Lisa A. Harvey; Joanne V. Glinsky; Jackie Chu; Robert D. Herbert; Hueiming Liu; Stephen Jan; Laurent Billot; Giorgio Scivoletto; Annemie I. Spooren; Henk A. Seelen; Marsha Ben; Keira Tranter; Lydia W. Chen; Donna Rainey; Christine Rimmer; Vivien Jorgensen; Fernanda Di Natal; Sophie Denis; Emilie J. Gollan; Federica Tamburella; Jacqui Agostinello; Charlotte M. van Laake-Geelen; Chris Bell; Claire Lincoln; Janneke M. Stolwijk; Jessica van der Lede; Sue Paddison; Kristine Oostra; Ian D. Cameron; Gerard Weber; Catherine Sherrington; Andrew K. Nunn; Emma-Leigh Synnott; Euan McCaughey; Jasbeer Kaur; Sachin Shetty

doi:10.1038/s41393-023-00908-z

Early and intensive motor training to enhance neurological recovery in people with spinal cord injury: trial protocol

Lisa A. Harvey^*, Joanne V. Glinsky, Jackie Chu, Robert D. Herbert, Hueiming Liu, Stephen Jan, Laurent Billot, Giorgio Scivoletto, Annemie I. Spooren, Henk A. Seelen, Marsha Ben, Keira Tranter, Lydia W. Chen, Donna Rainey, Christine Rimmer, Vivien Jorgensen, Fernanda Di Natal, Sophie Denis, Emilie J. Gollan, Federica TamburellaJacqui Agostinello, Charlotte M. van Laake-Geelen, Chris Bell, Claire Lincoln, Janneke M. Stolwijk, Jessica van der Lede, Sue Paddison, Kristine Oostra, Ian D. Cameron, Gerard Weber, Catherine Sherrington, Andrew K. Nunn, Emma-Leigh Synnott, Euan McCaughey, Jasbeer Kaur, Sachin Shetty

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Study designProtocol for a multi-centre randomised controlled trial (the SCI-MT trial).ObjectivesTo determine whether 10 weeks of intensive motor training enhances neurological recovery in people with recent spinal cord injury (SCI).SettingFifteen spinal injury units in Australia, Scotland, England, Italy, Netherlands, Norway, and Belgium.MethodsA pragmatic randomised controlled trial will be undertaken. Two hundred and twenty people with recent SCI (onset in the preceding 10 weeks, American Spinal Injuries Association Impairment Scale (AIS) A lesion with motor function more than three levels below the motor level on one or both sides, or an AIS C or D lesion) will be randomised to receive either usual care plus intensive motor training (12 h of motor training per week for 10 weeks) or usual care alone. The primary outcome is neurological recovery at 10 weeks, measured with the Total Motor Score from the International Standards for Neurological Classification of SCI. Secondary outcomes include global measures of motor function, ability to walk, quality of life, participants' perceptions about ability to perform self-selected goals, length of hospital stay and participants' impressions of therapeutic benefit at 10 weeks and 6 months. A cost-effectiveness study and process evaluation will be run alongside the trial. The first participant was randomised in June 2021 and the trial is due for completion in 2025.ConclusionsThe findings of the SCI-MT Trial will guide recommendations about the type and dose of inpatient therapy that optimises neurological recovery in people with SCI.

Original language	English
Pages (from-to)	521–527
Number of pages	7
Journal	Spinal Cord
Volume	61
Issue number	9
Early online date	1 Jul 2023
DOIs	https://doi.org/10.1038/s41393-023-00908-z
Publication status	Published - 1 Jul 2023

Keywords

EXTREMITY SKILLED PERFORMANCE
CLINICAL-TRIALS
ICCP PANEL
OCCUPATIONAL-THERAPY
PHYSICAL-THERAPY
GOAL ATTAINMENT
STROKE
REHABILITATION
INTERVENTIONS
GUIDELINES

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Cite this

Harvey, L. A., Glinsky, J. V., Chu, J., Herbert, R. D., Liu, H., Jan, S., Billot, L., Scivoletto, G., Spooren, A. I., Seelen, H. A., Ben, M., Tranter, K., Chen, L. W., Rainey, D., Rimmer, C., Jorgensen, V., Di Natal, F., Denis, S., Gollan, E. J., ... Shetty, S. (2023). Early and intensive motor training to enhance neurological recovery in people with spinal cord injury: trial protocol. Spinal Cord, 61(9), 521–527. https://doi.org/10.1038/s41393-023-00908-z

@article{747d452d745f48cbad9abee1a4bffead,

title = "Early and intensive motor training to enhance neurological recovery in people with spinal cord injury: trial protocol",

abstract = "Study designProtocol for a multi-centre randomised controlled trial (the SCI-MT trial).ObjectivesTo determine whether 10 weeks of intensive motor training enhances neurological recovery in people with recent spinal cord injury (SCI).SettingFifteen spinal injury units in Australia, Scotland, England, Italy, Netherlands, Norway, and Belgium.MethodsA pragmatic randomised controlled trial will be undertaken. Two hundred and twenty people with recent SCI (onset in the preceding 10 weeks, American Spinal Injuries Association Impairment Scale (AIS) A lesion with motor function more than three levels below the motor level on one or both sides, or an AIS C or D lesion) will be randomised to receive either usual care plus intensive motor training (12 h of motor training per week for 10 weeks) or usual care alone. The primary outcome is neurological recovery at 10 weeks, measured with the Total Motor Score from the International Standards for Neurological Classification of SCI. Secondary outcomes include global measures of motor function, ability to walk, quality of life, participants' perceptions about ability to perform self-selected goals, length of hospital stay and participants' impressions of therapeutic benefit at 10 weeks and 6 months. A cost-effectiveness study and process evaluation will be run alongside the trial. The first participant was randomised in June 2021 and the trial is due for completion in 2025.ConclusionsThe findings of the SCI-MT Trial will guide recommendations about the type and dose of inpatient therapy that optimises neurological recovery in people with SCI.",

keywords = "EXTREMITY SKILLED PERFORMANCE, CLINICAL-TRIALS, ICCP PANEL, OCCUPATIONAL-THERAPY, PHYSICAL-THERAPY, GOAL ATTAINMENT, STROKE, REHABILITATION, INTERVENTIONS, GUIDELINES",

author = "Harvey, {Lisa A.} and Glinsky, {Joanne V.} and Jackie Chu and Herbert, {Robert D.} and Hueiming Liu and Stephen Jan and Laurent Billot and Giorgio Scivoletto and Spooren, {Annemie I.} and Seelen, {Henk A.} and Marsha Ben and Keira Tranter and Chen, {Lydia W.} and Donna Rainey and Christine Rimmer and Vivien Jorgensen and {Di Natal}, Fernanda and Sophie Denis and Gollan, {Emilie J.} and Federica Tamburella and Jacqui Agostinello and {van Laake-Geelen}, {Charlotte M.} and Chris Bell and Claire Lincoln and Stolwijk, {Janneke M.} and {van der Lede}, Jessica and Sue Paddison and Kristine Oostra and Cameron, {Ian D.} and Gerard Weber and Catherine Sherrington and Nunn, {Andrew K.} and Emma-Leigh Synnott and Euan McCaughey and Jasbeer Kaur and Sachin Shetty",

year = "2023",

month = jul,

day = "1",

doi = "10.1038/s41393-023-00908-z",

language = "English",

volume = "61",

pages = "521–527",

journal = "Spinal Cord",

issn = "1362-4393",

publisher = "Nature Publishing Group",

number = "9",

}

Harvey, LA, Glinsky, JV, Chu, J, Herbert, RD, Liu, H, Jan, S, Billot, L, Scivoletto, G, Spooren, AI, Seelen, HA, Ben, M, Tranter, K, Chen, LW, Rainey, D, Rimmer, C, Jorgensen, V, Di Natal, F, Denis, S, Gollan, EJ, Tamburella, F, Agostinello, J, van Laake-Geelen, CM, Bell, C, Lincoln, C, Stolwijk, JM, van der Lede, J, Paddison, S, Oostra, K, Cameron, ID, Weber, G, Sherrington, C, Nunn, AK, Synnott, E-L, McCaughey, E, Kaur, J & Shetty, S 2023, 'Early and intensive motor training to enhance neurological recovery in people with spinal cord injury: trial protocol', Spinal Cord, vol. 61, no. 9, pp. 521–527. https://doi.org/10.1038/s41393-023-00908-z

TY - JOUR

T1 - Early and intensive motor training to enhance neurological recovery in people with spinal cord injury

T2 - trial protocol

AU - Harvey, Lisa A.

AU - Glinsky, Joanne V.

AU - Chu, Jackie

AU - Herbert, Robert D.

AU - Liu, Hueiming

AU - Jan, Stephen

AU - Billot, Laurent

AU - Scivoletto, Giorgio

AU - Spooren, Annemie I.

AU - Seelen, Henk A.

AU - Ben, Marsha

AU - Tranter, Keira

AU - Chen, Lydia W.

AU - Rainey, Donna

AU - Rimmer, Christine

AU - Jorgensen, Vivien

AU - Di Natal, Fernanda

AU - Denis, Sophie

AU - Gollan, Emilie J.

AU - Tamburella, Federica

AU - Agostinello, Jacqui

AU - van Laake-Geelen, Charlotte M.

AU - Bell, Chris

AU - Lincoln, Claire

AU - Stolwijk, Janneke M.

AU - van der Lede, Jessica

AU - Paddison, Sue

AU - Oostra, Kristine

AU - Cameron, Ian D.

AU - Weber, Gerard

AU - Sherrington, Catherine

AU - Nunn, Andrew K.

AU - Synnott, Emma-Leigh

AU - McCaughey, Euan

AU - Kaur, Jasbeer

AU - Shetty, Sachin

PY - 2023/7/1

Y1 - 2023/7/1

N2 - Study designProtocol for a multi-centre randomised controlled trial (the SCI-MT trial).ObjectivesTo determine whether 10 weeks of intensive motor training enhances neurological recovery in people with recent spinal cord injury (SCI).SettingFifteen spinal injury units in Australia, Scotland, England, Italy, Netherlands, Norway, and Belgium.MethodsA pragmatic randomised controlled trial will be undertaken. Two hundred and twenty people with recent SCI (onset in the preceding 10 weeks, American Spinal Injuries Association Impairment Scale (AIS) A lesion with motor function more than three levels below the motor level on one or both sides, or an AIS C or D lesion) will be randomised to receive either usual care plus intensive motor training (12 h of motor training per week for 10 weeks) or usual care alone. The primary outcome is neurological recovery at 10 weeks, measured with the Total Motor Score from the International Standards for Neurological Classification of SCI. Secondary outcomes include global measures of motor function, ability to walk, quality of life, participants' perceptions about ability to perform self-selected goals, length of hospital stay and participants' impressions of therapeutic benefit at 10 weeks and 6 months. A cost-effectiveness study and process evaluation will be run alongside the trial. The first participant was randomised in June 2021 and the trial is due for completion in 2025.ConclusionsThe findings of the SCI-MT Trial will guide recommendations about the type and dose of inpatient therapy that optimises neurological recovery in people with SCI.

AB - Study designProtocol for a multi-centre randomised controlled trial (the SCI-MT trial).ObjectivesTo determine whether 10 weeks of intensive motor training enhances neurological recovery in people with recent spinal cord injury (SCI).SettingFifteen spinal injury units in Australia, Scotland, England, Italy, Netherlands, Norway, and Belgium.MethodsA pragmatic randomised controlled trial will be undertaken. Two hundred and twenty people with recent SCI (onset in the preceding 10 weeks, American Spinal Injuries Association Impairment Scale (AIS) A lesion with motor function more than three levels below the motor level on one or both sides, or an AIS C or D lesion) will be randomised to receive either usual care plus intensive motor training (12 h of motor training per week for 10 weeks) or usual care alone. The primary outcome is neurological recovery at 10 weeks, measured with the Total Motor Score from the International Standards for Neurological Classification of SCI. Secondary outcomes include global measures of motor function, ability to walk, quality of life, participants' perceptions about ability to perform self-selected goals, length of hospital stay and participants' impressions of therapeutic benefit at 10 weeks and 6 months. A cost-effectiveness study and process evaluation will be run alongside the trial. The first participant was randomised in June 2021 and the trial is due for completion in 2025.ConclusionsThe findings of the SCI-MT Trial will guide recommendations about the type and dose of inpatient therapy that optimises neurological recovery in people with SCI.

KW - EXTREMITY SKILLED PERFORMANCE

KW - CLINICAL-TRIALS

KW - ICCP PANEL

KW - OCCUPATIONAL-THERAPY

KW - PHYSICAL-THERAPY

KW - GOAL ATTAINMENT

KW - STROKE

KW - REHABILITATION

KW - INTERVENTIONS

KW - GUIDELINES

U2 - 10.1038/s41393-023-00908-z

DO - 10.1038/s41393-023-00908-z

M3 - Article

C2 - 37414835

SN - 1362-4393

VL - 61

SP - 521

EP - 527

JO - Spinal Cord

JF - Spinal Cord

IS - 9

ER -