Dual-specificity phosphatases in mental and neurological disorders

N. An; K. Bassil; G.I. Al Jowf; H.W.M. Steinbusch; M. Rothermel; L. de Nijs; B.P.F. Rutten

doi:10.1016/j.pneurobio.2020.101906

Dual-specificity phosphatases in mental and neurological disorders

N. An, K. Bassil, G.I. Al Jowf, H.W.M. Steinbusch, M. Rothermel, L. de Nijs, B.P.F. Rutten^*

^*Corresponding author for this work

Research output: Contribution to journal › (Systematic) Review article › peer-review

Abstract

The dual-specificity phosphatase (DUSP) family includes a heterogeneous group of protein phosphatases that dephosphorylate both phospho-tyrosine and phospho-serine/phospho-threonine residues within a single substrate. These protein phosphatases have many substrates and modulate diverse neural functions, such as neurogenesis, differentiation, and apoptosis. DUSP genes have furthermore been associated with mental disorders such as depression and neurological disorders such as Alzheimer's disease. Herein, we review the current literature on the DUSP family of genes concerning mental and neurological disorders. This review i) outlines the structure and general functions of DUSP genes, and ii) overviews the literature on DUSP genes concerning mental and neurological disorders, including model systems, while furthermore providing perspectives for future research.

Original language	English
Article number	101906
Number of pages	19
Journal	Progress in Neurobiology
Volume	198
DOIs	https://doi.org/10.1016/j.pneurobio.2020.101906
Publication status	Published - 1 Mar 2021

Keywords

DUSP
Mental health
Neurological diseases
Phosphatase
Psychiatric disorders
dusp
mental health
neurological diseases
phosphatase
psychiatric disorders
LIM KINASE
ALZHEIMERS-DISEASE
AUTISM SPECTRUM DISORDERS
BIPOLAR DISORDER
GENE-EXPRESSION CHANGES
TAU-PHOSPHORYLATION
PTEN TUMOR-SUPPRESSOR
MAP KINASE PHOSPHATASES
HUNTINGTONS-DISEASE
COFILIN PHOSPHORYLATION

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Cite this

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title = "Dual-specificity phosphatases in mental and neurological disorders",

abstract = "The dual-specificity phosphatase (DUSP) family includes a heterogeneous group of protein phosphatases that dephosphorylate both phospho-tyrosine and phospho-serine/phospho-threonine residues within a single substrate. These protein phosphatases have many substrates and modulate diverse neural functions, such as neurogenesis, differentiation, and apoptosis. DUSP genes have furthermore been associated with mental disorders such as depression and neurological disorders such as Alzheimer's disease. Herein, we review the current literature on the DUSP family of genes concerning mental and neurological disorders. This review i) outlines the structure and general functions of DUSP genes, and ii) overviews the literature on DUSP genes concerning mental and neurological disorders, including model systems, while furthermore providing perspectives for future research.",

keywords = "DUSP, Mental health, Neurological diseases, Phosphatase, Psychiatric disorders, dusp, mental health, neurological diseases, phosphatase, psychiatric disorders, LIM KINASE, ALZHEIMERS-DISEASE, AUTISM SPECTRUM DISORDERS, BIPOLAR DISORDER, GENE-EXPRESSION CHANGES, TAU-PHOSPHORYLATION, PTEN TUMOR-SUPPRESSOR, MAP KINASE PHOSPHATASES, HUNTINGTONS-DISEASE, COFILIN PHOSPHORYLATION",

author = "N. An and K. Bassil and {Al Jowf}, G.I. and H.W.M. Steinbusch and M. Rothermel and {de Nijs}, L. and B.P.F. Rutten",

note = "Funding Information: Work from Ning An was supported by the China Scholarship Council (File No.201506750020). Work from Ghazi I. Al Jowf was supported by King Faisal University , Employees Scholarship Program from the Saudi Arabian Government (no. 1026374049) . Work from Dr. Markus Rothermel was supported by the DFG (RO4046/2-1 and /2-2, Emmy Noether Program; GRK2416). Work from B.P.F. Rutten was funded by a VIDI award (no. 91718336) from the Netherlands Scientific Organization . Funding Information: Work from Ning An was supported by the China Scholarship Council (File No.201506750020). Work from Ghazi I. Al Jowf was supported by King Faisal University, Employees Scholarship Program from the Saudi Arabian Government (no. 1026374049). Work from Dr. Markus Rothermel was supported by the DFG (RO4046/2-1 and /2-2, Emmy Noether Program; GRK2416). Work from B.P.F. Rutten was funded by a VIDI award (no. 91718336) from the Netherlands Scientific Organization. Publisher Copyright: {\textcopyright} 2020 The Author(s)",

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day = "1",

doi = "10.1016/j.pneurobio.2020.101906",

language = "English",

volume = "198",

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T1 - Dual-specificity phosphatases in mental and neurological disorders

AU - An, N.

AU - Bassil, K.

AU - Al Jowf, G.I.

AU - Steinbusch, H.W.M.

AU - Rothermel, M.

AU - de Nijs, L.

AU - Rutten, B.P.F.

N1 - Funding Information: Work from Ning An was supported by the China Scholarship Council (File No.201506750020). Work from Ghazi I. Al Jowf was supported by King Faisal University , Employees Scholarship Program from the Saudi Arabian Government (no. 1026374049) . Work from Dr. Markus Rothermel was supported by the DFG (RO4046/2-1 and /2-2, Emmy Noether Program; GRK2416). Work from B.P.F. Rutten was funded by a VIDI award (no. 91718336) from the Netherlands Scientific Organization . Funding Information: Work from Ning An was supported by the China Scholarship Council (File No.201506750020). Work from Ghazi I. Al Jowf was supported by King Faisal University, Employees Scholarship Program from the Saudi Arabian Government (no. 1026374049). Work from Dr. Markus Rothermel was supported by the DFG (RO4046/2-1 and /2-2, Emmy Noether Program; GRK2416). Work from B.P.F. Rutten was funded by a VIDI award (no. 91718336) from the Netherlands Scientific Organization. Publisher Copyright: © 2020 The Author(s)

PY - 2021/3/1

Y1 - 2021/3/1

N2 - The dual-specificity phosphatase (DUSP) family includes a heterogeneous group of protein phosphatases that dephosphorylate both phospho-tyrosine and phospho-serine/phospho-threonine residues within a single substrate. These protein phosphatases have many substrates and modulate diverse neural functions, such as neurogenesis, differentiation, and apoptosis. DUSP genes have furthermore been associated with mental disorders such as depression and neurological disorders such as Alzheimer's disease. Herein, we review the current literature on the DUSP family of genes concerning mental and neurological disorders. This review i) outlines the structure and general functions of DUSP genes, and ii) overviews the literature on DUSP genes concerning mental and neurological disorders, including model systems, while furthermore providing perspectives for future research.

AB - The dual-specificity phosphatase (DUSP) family includes a heterogeneous group of protein phosphatases that dephosphorylate both phospho-tyrosine and phospho-serine/phospho-threonine residues within a single substrate. These protein phosphatases have many substrates and modulate diverse neural functions, such as neurogenesis, differentiation, and apoptosis. DUSP genes have furthermore been associated with mental disorders such as depression and neurological disorders such as Alzheimer's disease. Herein, we review the current literature on the DUSP family of genes concerning mental and neurological disorders. This review i) outlines the structure and general functions of DUSP genes, and ii) overviews the literature on DUSP genes concerning mental and neurological disorders, including model systems, while furthermore providing perspectives for future research.

KW - DUSP

KW - Mental health

KW - Neurological diseases

KW - Phosphatase

KW - Psychiatric disorders

KW - dusp

KW - mental health

KW - neurological diseases

KW - phosphatase

KW - psychiatric disorders

KW - LIM KINASE

KW - ALZHEIMERS-DISEASE

KW - AUTISM SPECTRUM DISORDERS

KW - BIPOLAR DISORDER

KW - GENE-EXPRESSION CHANGES

KW - TAU-PHOSPHORYLATION

KW - PTEN TUMOR-SUPPRESSOR

KW - MAP KINASE PHOSPHATASES

KW - HUNTINGTONS-DISEASE

KW - COFILIN PHOSPHORYLATION

U2 - 10.1016/j.pneurobio.2020.101906

DO - 10.1016/j.pneurobio.2020.101906

M3 - (Systematic) Review article

C2 - 32905807

SN - 0301-0082

VL - 198

JO - Progress in Neurobiology

JF - Progress in Neurobiology

M1 - 101906

ER -