Drug-induced movement disorders in long-stay psychiatric patients : genetic and non-genetic risk factors : a prospective study

P.R. Bakker

Research output: ThesisDoctoral ThesisInternal

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On the site of a psychiatric hospital a man walks with a bent back, slowly with a shaking hand. What is the matter with him? This is one of the movement disorders caused by anti-psychotics.
This dissertation shows that movement disorders occur often in this patient group and that therefore prevention is crucial. The hope that the new anti-psychotics would make these horrible side-effects disappear turns out an illusion. Older age and higher anti-psychicum dose are risk factors for certain movement disorders. Analyses of earlier studies suggest multiple genetic influences. Also in additional research weak genetic signals were found that ask for larger long-term random studies, in which the fluctuating course of movement disorders and gene-environment interactions can be included.

Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Maastricht University
  • van Harten, P.N., Supervisor, External person
  • van Os, Jim, Supervisor
Award date23 May 2012
Place of PublicationMaastricht
Print ISBNs9789075579994
Publication statusPublished - 1 Jan 2012


  • movement disorders
  • anti-psychotics

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