Drug-Eluting Medical Textiles: From Fiber Production and Textile Fabrication to Drug Loading and Delivery

Matin Rostamitabar, Abdelrahman M Abdelgawad, Stefan Jockenhoevel, Samaneh Ghazanfari*

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

5 Citations (Web of Science)
111 Downloads (Pure)

Abstract

Drug-eluting medical textiles have recently gained great attention to be used in different applications due to their cost effectiveness and unique physical and chemical properties. Using various fiber production and textile fabrication technologies, fibrous constructs with the required properties for the target drug delivery systems can be designed and fabricated. This review summarizes the current advances in the fabrication of drug-eluting medical textiles. Different fiber production methods such as melt-, wet-, and electro-spinning, and textile fabrication techniques such as knitting and weaving are explained. Moreover, various loading processes of bioactive agents to obtain drug-loaded fibrous structures with required physicochemical and morphological properties, drug delivery mechanisms, and drug release kinetics are discussed. Finally, the current applications of drug-eluting fibrous systems in wound care, tissue engineering, and transdermal drug delivery are highlighted.

Original languageEnglish
Article number2100021
Pages (from-to)e2100021
Number of pages31
JournalMacromolecular Bioscience
Volume21
Issue number7
Early online date5 May 2021
DOIs
Publication statusPublished - Jul 2021

Keywords

  • controlled drug release
  • drug loading
  • fiber spinning
  • micro
  • nanofibers
  • release kinetics
  • ION-EXCHANGE FIBERS
  • CELLULOSE-ACETATE
  • SURFACE MODIFICATION
  • IN-VITRO
  • ANTIBACTERIAL ACTIVITY
  • NANOFIBROUS SCAFFOLDS
  • ELECTROSPUN FIBERS
  • POLYMER NANOFIBERS
  • CONTROLLED-RELEASE
  • WOUND DRESSINGS

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