Drivers of de novo Serine/Glycine synthesis in acute leukemia

Paulien Verstraete; Kim De Keersmaecker; Kim Rosalie Kampen

doi:10.1002/1873-3468.14700

Drivers of de novo Serine/Glycine synthesis in acute leukemia

Paulien Verstraete, Kim De Keersmaecker^*, Kim Rosalie Kampen

^*Corresponding author for this work

Research output: Contribution to journal › (Systematic) Review article › peer-review

Abstract

Cancer cells hijack metabolic pathways in order to provide themselves with building blocks to support their proliferation and survival. Upregulation and addiction to de novo serine/glycine synthesis is an example of metabolic rewiring in cancer cells whereby serine and glycine are synthesised via a side branch of glycolysis. In this review, we focus on upregulation of endogenous serine/glycine production in acute leukemia, namely T-cell acute leukemia (T-ALL) and acute myeloid leukemia (AML). Several genetic lesions directly driving the serine/glycine addiction in acute leukemia have been established. Additionally, indirect regulation of de novo serine/glycine synthesis is observed in acute leukemia.

Original language	English
Pages (from-to)	2145-2146
Number of pages	2
Journal	Febs Letters
Volume	597
Issue number	17
Early online date	1 Aug 2023
DOIs	https://doi.org/10.1002/1873-3468.14700
Publication status	Published - Sept 2023

Keywords

ALL
AML
DNMT3A
FLT3-ITD
glycine
NKX2-1
NOTCH1
RPL10
serine
sertraline
T-CELL
GLYCINE METABOLISM
SYNTHESIS PATHWAY
SERINE
GENES
P53
CONTRIBUTES
PROGRESSION
MUTATION
DELETION

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title = "Drivers of de novo Serine/Glycine synthesis in acute leukemia",

abstract = "Cancer cells hijack metabolic pathways in order to provide themselves with building blocks to support their proliferation and survival. Upregulation and addiction to de novo serine/glycine synthesis is an example of metabolic rewiring in cancer cells whereby serine and glycine are synthesised via a side branch of glycolysis. In this review, we focus on upregulation of endogenous serine/glycine production in acute leukemia, namely T-cell acute leukemia (T-ALL) and acute myeloid leukemia (AML). Several genetic lesions directly driving the serine/glycine addiction in acute leukemia have been established. Additionally, indirect regulation of de novo serine/glycine synthesis is observed in acute leukemia.",

keywords = "ALL, AML, DNMT3A, FLT3-ITD, glycine, NKX2-1, NOTCH1, RPL10, serine, sertraline, T-CELL, GLYCINE METABOLISM, SYNTHESIS PATHWAY, SERINE, GENES, P53, CONTRIBUTES, PROGRESSION, MUTATION, DELETION",

author = "Paulien Verstraete and {De Keersmaecker}, Kim and Kampen, {Kim Rosalie}",

year = "2023",

month = sep,

doi = "10.1002/1873-3468.14700",

language = "English",

volume = "597",

pages = "2145--2146",

journal = "Febs Letters",

issn = "0014-5793",

publisher = "Elsevier",

number = "17",

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TY - JOUR

T1 - Drivers of de novo Serine/Glycine synthesis in acute leukemia

AU - Verstraete, Paulien

AU - De Keersmaecker, Kim

AU - Kampen, Kim Rosalie

PY - 2023/9

Y1 - 2023/9

N2 - Cancer cells hijack metabolic pathways in order to provide themselves with building blocks to support their proliferation and survival. Upregulation and addiction to de novo serine/glycine synthesis is an example of metabolic rewiring in cancer cells whereby serine and glycine are synthesised via a side branch of glycolysis. In this review, we focus on upregulation of endogenous serine/glycine production in acute leukemia, namely T-cell acute leukemia (T-ALL) and acute myeloid leukemia (AML). Several genetic lesions directly driving the serine/glycine addiction in acute leukemia have been established. Additionally, indirect regulation of de novo serine/glycine synthesis is observed in acute leukemia.

AB - Cancer cells hijack metabolic pathways in order to provide themselves with building blocks to support their proliferation and survival. Upregulation and addiction to de novo serine/glycine synthesis is an example of metabolic rewiring in cancer cells whereby serine and glycine are synthesised via a side branch of glycolysis. In this review, we focus on upregulation of endogenous serine/glycine production in acute leukemia, namely T-cell acute leukemia (T-ALL) and acute myeloid leukemia (AML). Several genetic lesions directly driving the serine/glycine addiction in acute leukemia have been established. Additionally, indirect regulation of de novo serine/glycine synthesis is observed in acute leukemia.

KW - ALL

KW - AML

KW - DNMT3A

KW - FLT3-ITD

KW - glycine

KW - NKX2-1

KW - NOTCH1

KW - RPL10

KW - serine

KW - sertraline

KW - T-CELL

KW - GLYCINE METABOLISM

KW - SYNTHESIS PATHWAY

KW - SERINE

KW - GENES

KW - P53

KW - CONTRIBUTES

KW - PROGRESSION

KW - MUTATION

KW - DELETION

U2 - 10.1002/1873-3468.14700

DO - 10.1002/1873-3468.14700

M3 - (Systematic) Review article

C2 - 37526379

SN - 0014-5793

VL - 597

SP - 2145

EP - 2146

JO - Febs Letters

JF - Febs Letters

IS - 17

ER -

Drivers of de novo Serine/Glycine synthesis in acute leukemia

Abstract

Keywords

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