Does Extended Surgery Influence Health-Related Quality of Life in Patients With Rectal Cancer?

Ricardo G. Orsini, Thomas A. Vermeer, Marjan J. Traa, Grard A. P. Nieuwenhuijzen, Ignace H. J. T. de Hingh, Harm J. T. Rutten*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


BACKGROUND: In locally advanced rectal cancer, an extended resection peripheral to the mesorectal fascia is needed to achieve a radical resection. The influence of extended resections on health-related quality of life is unclear. OBJECTIVE: Differences in health-related quality of life and sexuality between patients receiving standard surgery and patients receiving extended surgery were examined, with a focus on age. DESIGN: Patients operated on for rectal cancer between 2000 and 2010 were selected from a database and invited to complete the European Organization for Research and Treatment of Cancer quality-of-life questionnaires (C30 and ColoRectal 38). SETTINGS: All patients were treated at the Catharina Hospital, Eindhoven, the Netherlands. PATIENTS: All patients received total mesorectal excision surgery or extended surgery for rectal cancer. MAIN OUTCOME MEASURES: Health-related quality of life and sexual activity was compared between patients treated with total mesorectal excision surgery and extended surgery and further stratified by age at the time of surgery (= 70). RESULTS: Two hundred twenty-nine (64.1%) patients with standard surgery and 128 (35.9%) patients treated with extended resections responded. Extended surgery in patients = 70 years had lower sexual function and more male sexual dysfunction than patients
Original languageEnglish
Pages (from-to)179-185
JournalDiseases of the Colon & Rectum
Issue number2
Publication statusPublished - Feb 2015


  • Rectal cancer
  • Quality of life
  • Surgery
  • Elderly


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