diXa: a data infrastructure for chemical safety assessment

Diana Hendrickx, Hugo Aerts, Florian Caiment, D. Clark, T.M. Ebbels, C.T. Evelo, H. Gmuender, D.G. Hebels, R. Herwig, J. Hescheler, D.G. Jennen, M.J. Jetten, S. Kanterakis, H.C. Keun, V. Matser, J.P. Overington, E. Pilicheva, U. Sarkans, M.P. Segura-Lepe, I. SotiriadouT. Wittenberger, C. Wittwehr, A. Zanzi, J.C. Kleinjans

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Abstract

MOTIVATION: The field of toxicogenomics (the application of '-omics' technologies to risk assessment of compound toxicities) has expanded in the last decade, partly driven by new legislation, aimed at reducing animal testing in chemical risk assessment but mainly as a result of a paradigm change in toxicology towards the use and integration of genome wide data. Many research groups worldwide have generated large amounts of such toxicogenomics data. However, there is no centralized repository for archiving and making these data and associated tools for their analysis easily available. RESULTS: The Data Infrastructure for Chemical Safety Assessment (diXa) is a robust and sustainable infrastructure storing toxicogenomics data. A central data warehouse is connected to a portal with links to chemical information and molecular and phenotype data. diXa is publicly available through a user-friendly web interface. New data can be readily deposited into diXa using guidelines and templates available online. Analysis descriptions and tools for interrogating the data are available via the diXa portal. Availability: http://www.dixa-fp7.eu CONTACT: d.hendrickx@maastrichtuniversity.nl ; info@dixa-fp7.eu SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.
Original languageEnglish
Pages (from-to)1505-1507
Number of pages3
JournalBioinformatics
Volume31
Issue number9
DOIs
Publication statusPublished - 1 May 2015

Keywords

  • TOXICOLOGY

Cite this

Hendrickx, Diana ; Aerts, Hugo ; Caiment, Florian ; Clark, D. ; Ebbels, T.M. ; Evelo, C.T. ; Gmuender, H. ; Hebels, D.G. ; Herwig, R. ; Hescheler, J. ; Jennen, D.G. ; Jetten, M.J. ; Kanterakis, S. ; Keun, H.C. ; Matser, V. ; Overington, J.P. ; Pilicheva, E. ; Sarkans, U. ; Segura-Lepe, M.P. ; Sotiriadou, I. ; Wittenberger, T. ; Wittwehr, C. ; Zanzi, A. ; Kleinjans, J.C. / diXa: a data infrastructure for chemical safety assessment. In: Bioinformatics. 2015 ; Vol. 31, No. 9. pp. 1505-1507.
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abstract = "MOTIVATION: The field of toxicogenomics (the application of '-omics' technologies to risk assessment of compound toxicities) has expanded in the last decade, partly driven by new legislation, aimed at reducing animal testing in chemical risk assessment but mainly as a result of a paradigm change in toxicology towards the use and integration of genome wide data. Many research groups worldwide have generated large amounts of such toxicogenomics data. However, there is no centralized repository for archiving and making these data and associated tools for their analysis easily available. RESULTS: The Data Infrastructure for Chemical Safety Assessment (diXa) is a robust and sustainable infrastructure storing toxicogenomics data. A central data warehouse is connected to a portal with links to chemical information and molecular and phenotype data. diXa is publicly available through a user-friendly web interface. New data can be readily deposited into diXa using guidelines and templates available online. Analysis descriptions and tools for interrogating the data are available via the diXa portal. Availability: http://www.dixa-fp7.eu CONTACT: d.hendrickx@maastrichtuniversity.nl ; info@dixa-fp7.eu SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.",
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author = "Diana Hendrickx and Hugo Aerts and Florian Caiment and D. Clark and T.M. Ebbels and C.T. Evelo and H. Gmuender and D.G. Hebels and R. Herwig and J. Hescheler and D.G. Jennen and M.J. Jetten and S. Kanterakis and H.C. Keun and V. Matser and J.P. Overington and E. Pilicheva and U. Sarkans and M.P. Segura-Lepe and I. Sotiriadou and T. Wittenberger and C. Wittwehr and A. Zanzi and J.C. Kleinjans",
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Hendrickx, D, Aerts, H, Caiment, F, Clark, D, Ebbels, TM, Evelo, CT, Gmuender, H, Hebels, DG, Herwig, R, Hescheler, J, Jennen, DG, Jetten, MJ, Kanterakis, S, Keun, HC, Matser, V, Overington, JP, Pilicheva, E, Sarkans, U, Segura-Lepe, MP, Sotiriadou, I, Wittenberger, T, Wittwehr, C, Zanzi, A & Kleinjans, JC 2015, 'diXa: a data infrastructure for chemical safety assessment', Bioinformatics, vol. 31, no. 9, pp. 1505-1507. https://doi.org/10.1093/bioinformatics/btu827

diXa: a data infrastructure for chemical safety assessment. / Hendrickx, Diana; Aerts, Hugo; Caiment, Florian; Clark, D.; Ebbels, T.M.; Evelo, C.T.; Gmuender, H.; Hebels, D.G.; Herwig, R.; Hescheler, J.; Jennen, D.G.; Jetten, M.J.; Kanterakis, S.; Keun, H.C.; Matser, V.; Overington, J.P.; Pilicheva, E.; Sarkans, U.; Segura-Lepe, M.P.; Sotiriadou, I.; Wittenberger, T.; Wittwehr, C.; Zanzi, A.; Kleinjans, J.C.

In: Bioinformatics, Vol. 31, No. 9, 01.05.2015, p. 1505-1507.

Research output: Contribution to journalArticleAcademicpeer-review

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T1 - diXa: a data infrastructure for chemical safety assessment

AU - Hendrickx, Diana

AU - Aerts, Hugo

AU - Caiment, Florian

AU - Clark, D.

AU - Ebbels, T.M.

AU - Evelo, C.T.

AU - Gmuender, H.

AU - Hebels, D.G.

AU - Herwig, R.

AU - Hescheler, J.

AU - Jennen, D.G.

AU - Jetten, M.J.

AU - Kanterakis, S.

AU - Keun, H.C.

AU - Matser, V.

AU - Overington, J.P.

AU - Pilicheva, E.

AU - Sarkans, U.

AU - Segura-Lepe, M.P.

AU - Sotiriadou, I.

AU - Wittenberger, T.

AU - Wittwehr, C.

AU - Zanzi, A.

AU - Kleinjans, J.C.

PY - 2015/5/1

Y1 - 2015/5/1

N2 - MOTIVATION: The field of toxicogenomics (the application of '-omics' technologies to risk assessment of compound toxicities) has expanded in the last decade, partly driven by new legislation, aimed at reducing animal testing in chemical risk assessment but mainly as a result of a paradigm change in toxicology towards the use and integration of genome wide data. Many research groups worldwide have generated large amounts of such toxicogenomics data. However, there is no centralized repository for archiving and making these data and associated tools for their analysis easily available. RESULTS: The Data Infrastructure for Chemical Safety Assessment (diXa) is a robust and sustainable infrastructure storing toxicogenomics data. A central data warehouse is connected to a portal with links to chemical information and molecular and phenotype data. diXa is publicly available through a user-friendly web interface. New data can be readily deposited into diXa using guidelines and templates available online. Analysis descriptions and tools for interrogating the data are available via the diXa portal. Availability: http://www.dixa-fp7.eu CONTACT: d.hendrickx@maastrichtuniversity.nl ; info@dixa-fp7.eu SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.

AB - MOTIVATION: The field of toxicogenomics (the application of '-omics' technologies to risk assessment of compound toxicities) has expanded in the last decade, partly driven by new legislation, aimed at reducing animal testing in chemical risk assessment but mainly as a result of a paradigm change in toxicology towards the use and integration of genome wide data. Many research groups worldwide have generated large amounts of such toxicogenomics data. However, there is no centralized repository for archiving and making these data and associated tools for their analysis easily available. RESULTS: The Data Infrastructure for Chemical Safety Assessment (diXa) is a robust and sustainable infrastructure storing toxicogenomics data. A central data warehouse is connected to a portal with links to chemical information and molecular and phenotype data. diXa is publicly available through a user-friendly web interface. New data can be readily deposited into diXa using guidelines and templates available online. Analysis descriptions and tools for interrogating the data are available via the diXa portal. Availability: http://www.dixa-fp7.eu CONTACT: d.hendrickx@maastrichtuniversity.nl ; info@dixa-fp7.eu SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.

KW - TOXICOLOGY

U2 - 10.1093/bioinformatics/btu827

DO - 10.1093/bioinformatics/btu827

M3 - Article

VL - 31

SP - 1505

EP - 1507

JO - Bioinformatics

JF - Bioinformatics

SN - 1367-4803

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