Distribution of regional lymph lode metastasis in unilateral nasopharyngeal carcinoma and the suggestions for selective prophylactic irradiation with intensity-modulated radiotherapy

Feifei Lin; Zichen Qiu; Dehuan Xie; Xiong Zhou; Lei Wang; Zheng Wu; Wanqin Cheng; Shaowen Lyu; Yong Su; Yalan Tao

doi:10.1002/cam4.6614

Distribution of regional lymph lode metastasis in unilateral nasopharyngeal carcinoma and the suggestions for selective prophylactic irradiation with intensity-modulated radiotherapy

Feifei Lin, Zichen Qiu, Dehuan Xie, Xiong Zhou, Lei Wang, Zheng Wu, Wanqin Cheng, Shaowen Lyu, Yong Su^*, Yalan Tao^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Purpose: To address the regional lymph node (RLN) distribution and the long-term efficacy in unilateral nasopharyngeal carcinoma (NPC), providing elective irradiation for RLN with intensity-modulated radiotherapy (IMRT). Methods: The involvement of clinical data of 136 patients with unilateral NPC, who underwent IMRT from November 2003 to December 2020 were analyzed retrospectively. The therapeutic effect and failure pattern of RLN metastasis were evaluated. Results: Of 57.1% patients have bilateral RLN metastasis. The rate of contralateral RLNs metastasis is lower than that of ipsilateral RLNs. Contralateral RLN metastasis mainly occurs in level VIIa (39.0%) and II (38.2%). While level IVa is only 0.7%, and none of RLN metastasis was found in level IVb and Va. The median follow-up was 70 months, and the 3-, 5-and 10-year regional recurrence-free survival (RRFS) were 94.1%, 93.1%, and 93.1%, respectively. Conclusion: Routine prophylactic irradiation may not include contralateral lower neck LN and level Va for N0-1 unilateral NPC.

Original language	English
Pages (from-to)	20511-20520
Number of pages	10
Journal	Cancer Medicine
Volume	12
Issue number	21
DOIs	https://doi.org/10.1002/cam4.6614
Publication status	Published - 1 Jan 2023

Keywords

contralateral lymph node
intensity-modulated radiotherapy
regional lymph node metastasis
selective prophylactic irradiation
unilateral nasopharyngeal carcinoma

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Cite this

@article{7a56e83ca7084f819ed7bee0f8977a61,

title = "Distribution of regional lymph lode metastasis in unilateral nasopharyngeal carcinoma and the suggestions for selective prophylactic irradiation with intensity-modulated radiotherapy",

abstract = "Purpose: To address the regional lymph node (RLN) distribution and the long-term efficacy in unilateral nasopharyngeal carcinoma (NPC), providing elective irradiation for RLN with intensity-modulated radiotherapy (IMRT). Methods: The involvement of clinical data of 136 patients with unilateral NPC, who underwent IMRT from November 2003 to December 2020 were analyzed retrospectively. The therapeutic effect and failure pattern of RLN metastasis were evaluated. Results: Of 57.1% patients have bilateral RLN metastasis. The rate of contralateral RLNs metastasis is lower than that of ipsilateral RLNs. Contralateral RLN metastasis mainly occurs in level VIIa (39.0%) and II (38.2%). While level IVa is only 0.7%, and none of RLN metastasis was found in level IVb and Va. The median follow-up was 70 months, and the 3-, 5-and 10-year regional recurrence-free survival (RRFS) were 94.1%, 93.1%, and 93.1%, respectively. Conclusion: Routine prophylactic irradiation may not include contralateral lower neck LN and level Va for N0-1 unilateral NPC.",

keywords = "contralateral lymph node, intensity-modulated radiotherapy, regional lymph node metastasis, selective prophylactic irradiation, unilateral nasopharyngeal carcinoma",

author = "Feifei Lin and Zichen Qiu and Dehuan Xie and Xiong Zhou and Lei Wang and Zheng Wu and Wanqin Cheng and Shaowen Lyu and Yong Su and Yalan Tao",

note = "Publisher Copyright: {\textcopyright} 2023 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.",

year = "2023",

month = jan,

day = "1",

doi = "10.1002/cam4.6614",

language = "English",

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journal = "Cancer Medicine",

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Distribution of regional lymph lode metastasis in unilateral nasopharyngeal carcinoma and the suggestions for selective prophylactic irradiation with intensity-modulated radiotherapy. / Lin, Feifei; Qiu, Zichen; Xie, Dehuan et al.
In: Cancer Medicine, Vol. 12, No. 21, 01.01.2023, p. 20511-20520.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Distribution of regional lymph lode metastasis in unilateral nasopharyngeal carcinoma and the suggestions for selective prophylactic irradiation with intensity-modulated radiotherapy

AU - Lin, Feifei

AU - Qiu, Zichen

AU - Xie, Dehuan

AU - Zhou, Xiong

AU - Wang, Lei

AU - Wu, Zheng

AU - Cheng, Wanqin

AU - Lyu, Shaowen

AU - Su, Yong

AU - Tao, Yalan

PY - 2023/1/1

Y1 - 2023/1/1

N2 - Purpose: To address the regional lymph node (RLN) distribution and the long-term efficacy in unilateral nasopharyngeal carcinoma (NPC), providing elective irradiation for RLN with intensity-modulated radiotherapy (IMRT). Methods: The involvement of clinical data of 136 patients with unilateral NPC, who underwent IMRT from November 2003 to December 2020 were analyzed retrospectively. The therapeutic effect and failure pattern of RLN metastasis were evaluated. Results: Of 57.1% patients have bilateral RLN metastasis. The rate of contralateral RLNs metastasis is lower than that of ipsilateral RLNs. Contralateral RLN metastasis mainly occurs in level VIIa (39.0%) and II (38.2%). While level IVa is only 0.7%, and none of RLN metastasis was found in level IVb and Va. The median follow-up was 70 months, and the 3-, 5-and 10-year regional recurrence-free survival (RRFS) were 94.1%, 93.1%, and 93.1%, respectively. Conclusion: Routine prophylactic irradiation may not include contralateral lower neck LN and level Va for N0-1 unilateral NPC.

AB - Purpose: To address the regional lymph node (RLN) distribution and the long-term efficacy in unilateral nasopharyngeal carcinoma (NPC), providing elective irradiation for RLN with intensity-modulated radiotherapy (IMRT). Methods: The involvement of clinical data of 136 patients with unilateral NPC, who underwent IMRT from November 2003 to December 2020 were analyzed retrospectively. The therapeutic effect and failure pattern of RLN metastasis were evaluated. Results: Of 57.1% patients have bilateral RLN metastasis. The rate of contralateral RLNs metastasis is lower than that of ipsilateral RLNs. Contralateral RLN metastasis mainly occurs in level VIIa (39.0%) and II (38.2%). While level IVa is only 0.7%, and none of RLN metastasis was found in level IVb and Va. The median follow-up was 70 months, and the 3-, 5-and 10-year regional recurrence-free survival (RRFS) were 94.1%, 93.1%, and 93.1%, respectively. Conclusion: Routine prophylactic irradiation may not include contralateral lower neck LN and level Va for N0-1 unilateral NPC.

KW - contralateral lymph node

KW - intensity-modulated radiotherapy

KW - regional lymph node metastasis

KW - selective prophylactic irradiation

KW - unilateral nasopharyngeal carcinoma

U2 - 10.1002/cam4.6614

DO - 10.1002/cam4.6614

M3 - Article

SN - 2045-7634

VL - 12

SP - 20511

EP - 20520

JO - Cancer Medicine

JF - Cancer Medicine

IS - 21

ER -