Distributed genetic architecture across the hippocampal formation implies common neuropathology across brain disorders

S. Bahrami*, K. Nordengen, A.A. Shadrin, O. Frei, D. Van der Meer, A.M. Dale, L.T. Westlye, O.A. Andreassen, T. Kaufmann*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Despite its major role in complex human functions across the lifespan, most notably navigation, learning and memory, much of the genetic architecture of the hippocampal formation is currently unexplored. Here, through multivariate genome-wide association analysis in volumetric data from 35,411 white British individuals, we reveal 177 unique genetic loci with distributed associations across the hippocampal formation. We identify genetic overlap with eight brain disorders with typical onset at different stages of life, where common genes suggest partly age- and disorder-independent mechanisms underlying hippocampal pathology.The hippocampus has been associated with memory traits and a variety of neurodegenerative and psychiatric disorders. Here, the authors have done a multivariate GWAS revealing 177 genetic loci, and overlap with various brain disorders may suggest partly age- and disorder-independent mechanisms underlying hippocampal pathology.
Original languageEnglish
Article number3436
Number of pages9
JournalNature Communications
Volume13
Issue number1
DOIs
Publication statusPublished - 15 Jun 2022

Keywords

  • GENOME-WIDE ASSOCIATION
  • GLYCINERGIC INHIBITION
  • PARKINSONS-DISEASE
  • RISK LOCI
  • RECEPTOR
  • METAANALYSIS
  • SYSTEM
  • SEGMENTATION
  • PLASTICITY
  • RESPONSES

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