Discovery and validation of plasma proteomic biomarkers relating to brain amyloid burden by SOMAscan assay

Liu Shi*, Sarah Westwood, Alison L. Baird, Laura Winchester, Valerija Dobricic, Fabian Kilpert, Shengjun Hong, Andre Franke, Abdul Hye, Nicholas J. Ashton, Angharad R. Morgan, Isabelle Bos, Stephanie J. B. Vos, Noel J. Buckley, Mara ten Kate, Philip Scheltens, Rik Vandenberghe, Silvy Gabel, Karen Meersmans, Sebastiaan EngelborghsEllen E. De Roeck, Kristel Sleegers, Giovanni B. Frisoni, Olivier Blin, Jill C. Richardson, Regis Bordet, Jose L. Molinuevo, Lorena Rami, Anders Wallin, Petronella Kettunen, Magda Tsolaki, Frans Verhey, Alberto Lleo, Daniel Alcolea, Julius Popp, Gwendoline Peyratout, Pablo Martinez-Lage, Mikel Tainta, Peter Johannsen, Charlotte E. Teunissen, Yvonne Freund-Levi, Lutz Froelich, Cristina Legido-Quigley, Frederik Barkhof, Kaj Blennow, Henrik Zetterberg, Susan Baker, B. Paul Morgan, Johannes Streffer, Pieter Jelle Visser, Lars Bertram, Simon Lovestone, Alejo J. Nevado-Holgado

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)1478-1488
Number of pages11
JournalAlzheimer's & Dementia
Volume15
Issue number11
DOIs
Publication statusPublished - Nov 2019

Keywords

  • Amyloid beta
  • SOMAscan assay
  • Plasma proteomics
  • Replication
  • Causal relationship
  • Tau
  • BLOOD-BASED BIOMARKERS
  • ALZHEIMERS-DISEASE
  • MENDELIAN RANDOMIZATION
  • CASCADE HYPOTHESIS
  • SIGNALING PATHWAYS
  • MARKERS
  • TAU
  • MODELS
  • DRUG
  • AGE

Cite this

Shi, L., Westwood, S., Baird, A. L., Winchester, L., Dobricic, V., Kilpert, F., ... Nevado-Holgado, A. J. (2019). Discovery and validation of plasma proteomic biomarkers relating to brain amyloid burden by SOMAscan assay. Alzheimer's & Dementia, 15(11), 1478-1488. https://doi.org/10.1016/j.jalz.2019.06.4951
Shi, Liu ; Westwood, Sarah ; Baird, Alison L. ; Winchester, Laura ; Dobricic, Valerija ; Kilpert, Fabian ; Hong, Shengjun ; Franke, Andre ; Hye, Abdul ; Ashton, Nicholas J. ; Morgan, Angharad R. ; Bos, Isabelle ; Vos, Stephanie J. B. ; Buckley, Noel J. ; ten Kate, Mara ; Scheltens, Philip ; Vandenberghe, Rik ; Gabel, Silvy ; Meersmans, Karen ; Engelborghs, Sebastiaan ; De Roeck, Ellen E. ; Sleegers, Kristel ; Frisoni, Giovanni B. ; Blin, Olivier ; Richardson, Jill C. ; Bordet, Regis ; Molinuevo, Jose L. ; Rami, Lorena ; Wallin, Anders ; Kettunen, Petronella ; Tsolaki, Magda ; Verhey, Frans ; Lleo, Alberto ; Alcolea, Daniel ; Popp, Julius ; Peyratout, Gwendoline ; Martinez-Lage, Pablo ; Tainta, Mikel ; Johannsen, Peter ; Teunissen, Charlotte E. ; Freund-Levi, Yvonne ; Froelich, Lutz ; Legido-Quigley, Cristina ; Barkhof, Frederik ; Blennow, Kaj ; Zetterberg, Henrik ; Baker, Susan ; Morgan, B. Paul ; Streffer, Johannes ; Visser, Pieter Jelle ; Bertram, Lars ; Lovestone, Simon ; Nevado-Holgado, Alejo J. / Discovery and validation of plasma proteomic biomarkers relating to brain amyloid burden by SOMAscan assay. In: Alzheimer's & Dementia. 2019 ; Vol. 15, No. 11. pp. 1478-1488.
@article{9b34d3a1056d4b24879054dfda3b883f,
title = "Discovery and validation of plasma proteomic biomarkers relating to brain amyloid burden by SOMAscan assay",
keywords = "Amyloid beta, SOMAscan assay, Plasma proteomics, Replication, Causal relationship, Tau, BLOOD-BASED BIOMARKERS, ALZHEIMERS-DISEASE, MENDELIAN RANDOMIZATION, CASCADE HYPOTHESIS, SIGNALING PATHWAYS, MARKERS, TAU, MODELS, DRUG, AGE",
author = "Liu Shi and Sarah Westwood and Baird, {Alison L.} and Laura Winchester and Valerija Dobricic and Fabian Kilpert and Shengjun Hong and Andre Franke and Abdul Hye and Ashton, {Nicholas J.} and Morgan, {Angharad R.} and Isabelle Bos and Vos, {Stephanie J. B.} and Buckley, {Noel J.} and {ten Kate}, Mara and Philip Scheltens and Rik Vandenberghe and Silvy Gabel and Karen Meersmans and Sebastiaan Engelborghs and {De Roeck}, {Ellen E.} and Kristel Sleegers and Frisoni, {Giovanni B.} and Olivier Blin and Richardson, {Jill C.} and Regis Bordet and Molinuevo, {Jose L.} and Lorena Rami and Anders Wallin and Petronella Kettunen and Magda Tsolaki and Frans Verhey and Alberto Lleo and Daniel Alcolea and Julius Popp and Gwendoline Peyratout and Pablo Martinez-Lage and Mikel Tainta and Peter Johannsen and Teunissen, {Charlotte E.} and Yvonne Freund-Levi and Lutz Froelich and Cristina Legido-Quigley and Frederik Barkhof and Kaj Blennow and Henrik Zetterberg and Susan Baker and Morgan, {B. Paul} and Johannes Streffer and Visser, {Pieter Jelle} and Lars Bertram and Simon Lovestone and Nevado-Holgado, {Alejo J.}",
year = "2019",
month = "11",
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language = "English",
volume = "15",
pages = "1478--1488",
journal = "Alzheimer's & Dementia",
issn = "1552-5260",
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Shi, L, Westwood, S, Baird, AL, Winchester, L, Dobricic, V, Kilpert, F, Hong, S, Franke, A, Hye, A, Ashton, NJ, Morgan, AR, Bos, I, Vos, SJB, Buckley, NJ, ten Kate, M, Scheltens, P, Vandenberghe, R, Gabel, S, Meersmans, K, Engelborghs, S, De Roeck, EE, Sleegers, K, Frisoni, GB, Blin, O, Richardson, JC, Bordet, R, Molinuevo, JL, Rami, L, Wallin, A, Kettunen, P, Tsolaki, M, Verhey, F, Lleo, A, Alcolea, D, Popp, J, Peyratout, G, Martinez-Lage, P, Tainta, M, Johannsen, P, Teunissen, CE, Freund-Levi, Y, Froelich, L, Legido-Quigley, C, Barkhof, F, Blennow, K, Zetterberg, H, Baker, S, Morgan, BP, Streffer, J, Visser, PJ, Bertram, L, Lovestone, S & Nevado-Holgado, AJ 2019, 'Discovery and validation of plasma proteomic biomarkers relating to brain amyloid burden by SOMAscan assay', Alzheimer's & Dementia, vol. 15, no. 11, pp. 1478-1488. https://doi.org/10.1016/j.jalz.2019.06.4951

Discovery and validation of plasma proteomic biomarkers relating to brain amyloid burden by SOMAscan assay. / Shi, Liu; Westwood, Sarah; Baird, Alison L.; Winchester, Laura; Dobricic, Valerija; Kilpert, Fabian; Hong, Shengjun; Franke, Andre; Hye, Abdul; Ashton, Nicholas J.; Morgan, Angharad R.; Bos, Isabelle; Vos, Stephanie J. B.; Buckley, Noel J.; ten Kate, Mara; Scheltens, Philip; Vandenberghe, Rik; Gabel, Silvy; Meersmans, Karen; Engelborghs, Sebastiaan; De Roeck, Ellen E.; Sleegers, Kristel; Frisoni, Giovanni B.; Blin, Olivier; Richardson, Jill C.; Bordet, Regis; Molinuevo, Jose L.; Rami, Lorena; Wallin, Anders; Kettunen, Petronella; Tsolaki, Magda; Verhey, Frans; Lleo, Alberto; Alcolea, Daniel; Popp, Julius; Peyratout, Gwendoline; Martinez-Lage, Pablo; Tainta, Mikel; Johannsen, Peter; Teunissen, Charlotte E.; Freund-Levi, Yvonne; Froelich, Lutz; Legido-Quigley, Cristina; Barkhof, Frederik; Blennow, Kaj; Zetterberg, Henrik; Baker, Susan; Morgan, B. Paul; Streffer, Johannes; Visser, Pieter Jelle; Bertram, Lars; Lovestone, Simon; Nevado-Holgado, Alejo J.

In: Alzheimer's & Dementia, Vol. 15, No. 11, 11.2019, p. 1478-1488.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Discovery and validation of plasma proteomic biomarkers relating to brain amyloid burden by SOMAscan assay

AU - Shi, Liu

AU - Westwood, Sarah

AU - Baird, Alison L.

AU - Winchester, Laura

AU - Dobricic, Valerija

AU - Kilpert, Fabian

AU - Hong, Shengjun

AU - Franke, Andre

AU - Hye, Abdul

AU - Ashton, Nicholas J.

AU - Morgan, Angharad R.

AU - Bos, Isabelle

AU - Vos, Stephanie J. B.

AU - Buckley, Noel J.

AU - ten Kate, Mara

AU - Scheltens, Philip

AU - Vandenberghe, Rik

AU - Gabel, Silvy

AU - Meersmans, Karen

AU - Engelborghs, Sebastiaan

AU - De Roeck, Ellen E.

AU - Sleegers, Kristel

AU - Frisoni, Giovanni B.

AU - Blin, Olivier

AU - Richardson, Jill C.

AU - Bordet, Regis

AU - Molinuevo, Jose L.

AU - Rami, Lorena

AU - Wallin, Anders

AU - Kettunen, Petronella

AU - Tsolaki, Magda

AU - Verhey, Frans

AU - Lleo, Alberto

AU - Alcolea, Daniel

AU - Popp, Julius

AU - Peyratout, Gwendoline

AU - Martinez-Lage, Pablo

AU - Tainta, Mikel

AU - Johannsen, Peter

AU - Teunissen, Charlotte E.

AU - Freund-Levi, Yvonne

AU - Froelich, Lutz

AU - Legido-Quigley, Cristina

AU - Barkhof, Frederik

AU - Blennow, Kaj

AU - Zetterberg, Henrik

AU - Baker, Susan

AU - Morgan, B. Paul

AU - Streffer, Johannes

AU - Visser, Pieter Jelle

AU - Bertram, Lars

AU - Lovestone, Simon

AU - Nevado-Holgado, Alejo J.

PY - 2019/11

Y1 - 2019/11

KW - Amyloid beta

KW - SOMAscan assay

KW - Plasma proteomics

KW - Replication

KW - Causal relationship

KW - Tau

KW - BLOOD-BASED BIOMARKERS

KW - ALZHEIMERS-DISEASE

KW - MENDELIAN RANDOMIZATION

KW - CASCADE HYPOTHESIS

KW - SIGNALING PATHWAYS

KW - MARKERS

KW - TAU

KW - MODELS

KW - DRUG

KW - AGE

U2 - 10.1016/j.jalz.2019.06.4951

DO - 10.1016/j.jalz.2019.06.4951

M3 - Article

VL - 15

SP - 1478

EP - 1488

JO - Alzheimer's & Dementia

JF - Alzheimer's & Dementia

SN - 1552-5260

IS - 11

ER -