Abstract
The main goal of this methodological thesis was to present optimised magnetic resonance imaging (MRI) sequences for ex vivo and in vivo studies in ultra-high field scanners (UHF, from 7 T and above, beyond the conventional 1.5 or even 3 T available in the clinics). The researchers mainly worked with the STEAM sequence, which overcame several of its restrictions in these scanners. It resulted in ultra-high resolution whole-brain MRI data for ex vivo studies (achieving 400 μm , or 0.4 mm, isotropic resolution), and very highly accelerated acquisition protocols for in vivo studies (up to x 54 times the current total possible acceleration). With the current feasibility of acquiring ultra-high resolution data and highly sampled multi-contrast MRI images, data-expensive signal models can be employed; but above all, the biological microstructure features in the brain can be easily more revealed from the resulted analysis.
Original language | English |
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Awarding Institution |
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Supervisors/Advisors |
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Award date | 11 Jan 2021 |
Place of Publication | Maastricht |
Publisher | |
Print ISBNs | 9789464211764 |
DOIs | |
Publication status | Published - 2021 |
Keywords
- high resolution MRI
- high multi-contrast MRI
- ultra-high field MRI
- in vivo MRI histology
- diffusion-weighted MRI
- quantitative MRI