Diffusion-weighted magnetic resonance imaging at ultra-high field: From ex vivo to in vivo imaging of the human brain

Francisco Lagos Fritz

Research output: ThesisDoctoral ThesisInternal

464 Downloads (Pure)


The main goal of this methodological thesis was to present optimised magnetic resonance imaging (MRI) sequences for ex vivo and in vivo studies in ultra-high field scanners (UHF, from 7 T and above, beyond the conventional 1.5 or even 3 T available in the clinics). The researchers mainly worked with the STEAM sequence, which overcame several of its restrictions in these scanners. It resulted in ultra-high resolution whole-brain MRI data for ex vivo studies (achieving 400 μm , or 0.4 mm, isotropic resolution), and very highly accelerated acquisition protocols for in vivo studies (up to x 54 times the current total possible acceleration). With the current feasibility of acquiring ultra-high resolution data and highly sampled multi-contrast MRI images, data-expensive signal models can be employed; but above all, the biological microstructure features in the brain can be easily more revealed from the resulted analysis.
Original languageEnglish
Awarding Institution
  • Maastricht University
  • Roebroeck, Alard, Supervisor
  • Goebel, Rainer, Supervisor
  • Poser, Benedikt, Co-Supervisor
Award date11 Jan 2021
Place of PublicationMaastricht
Print ISBNs9789464211764
Publication statusPublished - 2021


  • high resolution MRI
  • high multi-contrast MRI
  • ultra-high field MRI
  • in vivo MRI histology
  • diffusion-weighted MRI
  • quantitative MRI

Cite this