Diffusion-weighted magnetic resonance imaging at ultra-high field: From ex vivo to in vivo imaging of the human brain

Francisco Lagos Fritz

doi:10.26481/dis.20210111flf

Diffusion-weighted magnetic resonance imaging at ultra-high field: From ex vivo to in vivo imaging of the human brain

Francisco Lagos Fritz

Research output: Thesis › Doctoral Thesis › Internal

464 Downloads (Pure)

Abstract

The main goal of this methodological thesis was to present optimised magnetic resonance imaging (MRI) sequences for ex vivo and in vivo studies in ultra-high field scanners (UHF, from 7 T and above, beyond the conventional 1.5 or even 3 T available in the clinics). The researchers mainly worked with the STEAM sequence, which overcame several of its restrictions in these scanners. It resulted in ultra-high resolution whole-brain MRI data for ex vivo studies (achieving 400 μm , or 0.4 mm, isotropic resolution), and very highly accelerated acquisition protocols for in vivo studies (up to x 54 times the current total possible acceleration). With the current feasibility of acquiring ultra-high resolution data and highly sampled multi-contrast MRI images, data-expensive signal models can be employed; but above all, the biological microstructure features in the brain can be easily more revealed from the resulted analysis.

Original language	English
Awarding Institution	Maastricht University
Supervisors/Advisors	Roebroeck, Alard, Supervisor Goebel, Rainer, Supervisor Poser, Benedikt, Co-Supervisor
Award date	11 Jan 2021
Place of Publication	Maastricht
Publisher	Ipskamp Printing BV
Print ISBNs	9789464211764
DOIs	https://doi.org/10.26481/dis.20210111flf
Publication status	Published - 2021

Keywords

high resolution MRI
high multi-contrast MRI
ultra-high field MRI
in vivo MRI histology
diffusion-weighted MRI
quantitative MRI

Access to Document

10.26481/dis.20210111flf

Full TextFinal published version, 41.4 MB
PropositionsFinal published version, 56.2 KB
CoverFinal published version, 28.7 KB
ValorisationFinal published version, 125 KB

Cite this

@phdthesis{02d0f13293af41c7946795b1769a5357,

title = "Diffusion-weighted magnetic resonance imaging at ultra-high field: From ex vivo to in vivo imaging of the human brain",

abstract = "The main goal of this methodological thesis was to present optimised magnetic resonance imaging (MRI) sequences for ex vivo and in vivo studies in ultra-high field scanners (UHF, from 7 T and above, beyond the conventional 1.5 or even 3 T available in the clinics). The researchers mainly worked with the STEAM sequence, which overcame several of its restrictions in these scanners. It resulted in ultra-high resolution whole-brain MRI data for ex vivo studies (achieving 400 μm , or 0.4 mm, isotropic resolution), and very highly accelerated acquisition protocols for in vivo studies (up to x 54 times the current total possible acceleration). With the current feasibility of acquiring ultra-high resolution data and highly sampled multi-contrast MRI images, data-expensive signal models can be employed; but above all, the biological microstructure features in the brain can be easily more revealed from the resulted analysis.",

keywords = "high resolution MRI, high multi-contrast MRI, ultra-high field MRI, in vivo MRI histology, diffusion-weighted MRI, quantitative MRI",

author = "{Lagos Fritz}, Francisco",

year = "2021",

doi = "10.26481/dis.20210111flf",

language = "English",

isbn = "9789464211764",

publisher = "Ipskamp Printing BV",

address = "Netherlands",

school = "Maastricht University",

}

TY - THES

T1 - Diffusion-weighted magnetic resonance imaging at ultra-high field

T2 - From ex vivo to in vivo imaging of the human brain

AU - Lagos Fritz, Francisco

PY - 2021

Y1 - 2021

N2 - The main goal of this methodological thesis was to present optimised magnetic resonance imaging (MRI) sequences for ex vivo and in vivo studies in ultra-high field scanners (UHF, from 7 T and above, beyond the conventional 1.5 or even 3 T available in the clinics). The researchers mainly worked with the STEAM sequence, which overcame several of its restrictions in these scanners. It resulted in ultra-high resolution whole-brain MRI data for ex vivo studies (achieving 400 μm , or 0.4 mm, isotropic resolution), and very highly accelerated acquisition protocols for in vivo studies (up to x 54 times the current total possible acceleration). With the current feasibility of acquiring ultra-high resolution data and highly sampled multi-contrast MRI images, data-expensive signal models can be employed; but above all, the biological microstructure features in the brain can be easily more revealed from the resulted analysis.

AB - The main goal of this methodological thesis was to present optimised magnetic resonance imaging (MRI) sequences for ex vivo and in vivo studies in ultra-high field scanners (UHF, from 7 T and above, beyond the conventional 1.5 or even 3 T available in the clinics). The researchers mainly worked with the STEAM sequence, which overcame several of its restrictions in these scanners. It resulted in ultra-high resolution whole-brain MRI data for ex vivo studies (achieving 400 μm , or 0.4 mm, isotropic resolution), and very highly accelerated acquisition protocols for in vivo studies (up to x 54 times the current total possible acceleration). With the current feasibility of acquiring ultra-high resolution data and highly sampled multi-contrast MRI images, data-expensive signal models can be employed; but above all, the biological microstructure features in the brain can be easily more revealed from the resulted analysis.

KW - high resolution MRI

KW - high multi-contrast MRI

KW - ultra-high field MRI

KW - in vivo MRI histology

KW - diffusion-weighted MRI

KW - quantitative MRI

U2 - 10.26481/dis.20210111flf

DO - 10.26481/dis.20210111flf

M3 - Doctoral Thesis

SN - 9789464211764

PB - Ipskamp Printing BV

CY - Maastricht

ER -