Diffusion-weighted magnetic resonance imaging at ultra-high field: From ex vivo to in vivo imaging of the human brain

Francisco Lagos Fritz

doi:10.26481/dis.20210111flf

Diffusion-weighted magnetic resonance imaging at ultra-high field: From ex vivo to in vivo imaging of the human brain

Francisco Lagos Fritz

Research output: Thesis › Doctoral Thesis › Internal

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Abstract

The main goal of this methodological thesis was to present optimised magnetic resonance imaging (MRI) sequences for ex vivo and in vivo studies in ultra-high field scanners (UHF, from 7 T and above, beyond the conventional 1.5 or even 3 T available in the clinics). The researchers mainly worked with the STEAM sequence, which overcame several of its restrictions in these scanners. It resulted in ultra-high resolution whole-brain MRI data for ex vivo studies (achieving 400 μm , or 0.4 mm, isotropic resolution), and very highly accelerated acquisition protocols for in vivo studies (up to x 54 times the current total possible acceleration). With the current feasibility of acquiring ultra-high resolution data and highly sampled multi-contrast MRI images, data-expensive signal models can be employed; but above all, the biological microstructure features in the brain can be easily more revealed from the resulted analysis.

Original language	English
Awarding Institution	Maastricht University
Supervisors/Advisors	Roebroeck, Alard, Supervisor Goebel, Rainer, Supervisor Poser, Benedikt, Co-Supervisor
Award date	11 Jan 2021
Place of Publication	Maastricht
Publisher	Ipskamp Printing BV
Print ISBNs	9789464211764
DOIs	https://doi.org/10.26481/dis.20210111flf
Publication status	Published - 2021

Keywords

high resolution MRI
high multi-contrast MRI
ultra-high field MRI
in vivo MRI histology
diffusion-weighted MRI
quantitative MRI

Access to Document

10.26481/dis.20210111flf

Full TextFinal published version, 41.4 MB
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ValorisationFinal published version, 125 KB

Cite this

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abstract = "The main goal of this methodological thesis was to present optimised magnetic resonance imaging (MRI) sequences for ex vivo and in vivo studies in ultra-high field scanners (UHF, from 7 T and above, beyond the conventional 1.5 or even 3 T available in the clinics). The researchers mainly worked with the STEAM sequence, which overcame several of its restrictions in these scanners. It resulted in ultra-high resolution whole-brain MRI data for ex vivo studies (achieving 400 μm , or 0.4 mm, isotropic resolution), and very highly accelerated acquisition protocols for in vivo studies (up to x 54 times the current total possible acceleration). With the current feasibility of acquiring ultra-high resolution data and highly sampled multi-contrast MRI images, data-expensive signal models can be employed; but above all, the biological microstructure features in the brain can be easily more revealed from the resulted analysis.",

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