Differential Effects of the beta-Adrenoceptor Blockers Carvedilol and Metoprolol on SQT1-and SQT2-Mutant Channels

Ilona Bodi, Gerlind Franke, Naga Deepa Pantulu, Kezhong Wu, Stefanie Perez-Feliz, Christoph Bode, Manfred Zehender, Axel Zur Hausen, Michael Brunner, Katja E. Odening*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Web of Science)

Abstract

-Blocker Effects on SQTS-Mutant K+ Channels BackgroundN588K-KCNH2 and V307L-KCNQ1 mutations lead to a gain-of-function of I-Kr and I-Ks thus causing short-QT syndromes (SQT1, SQT2). Combined pharmacotherapies using K+-channel-blockers and -blockers are ef
Original languageEnglish
Pages (from-to)1163-1171
JournalJournal of Cardiovascular Electrophysiology
Volume24
Issue number10
DOIs
Publication statusPublished - Oct 2013

Keywords

  • beta-adrenergic blocker
  • carvedilol
  • metoprolol
  • potassium current
  • short-QT syndrome

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