Differential effect of lacosamide on Nav1.7 variants from responsive and non-responsive patients with small fibre neuropathy

Julie I. R. Labau, Mark Estacion, Brian S. Tanaka, Bianca T. A. de Greef, Janneke G. J. Hoeijmakers, Margot Geerts, Monique M. Gerrits, Hubert J. M. Smeets, Catharina G. Faber, Ingemar S. J. Merkies, Giuseppe Lauria, Sulayman D. Dib-Hajj*, Stephen G. Waxman*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)771-782
Number of pages12
JournalBrain
Volume143
DOIs
Publication statusPublished - Mar 2020

Keywords

  • small fibre neuropathy
  • lacosamide
  • Na(v)1.7 mutations
  • neuropathic pain
  • electrophysiology
  • VOLTAGE-GATED SODIUM
  • MOLECULAR DETERMINANTS
  • SLOW-INACTIVATION
  • NA+ CHANNELS
  • PAIN
  • MUTATION
  • BINDING
  • INHIBITION
  • EFFICACY
  • NEURONS

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