TY - JOUR
T1 - Dietary intake of dicarbonyl compounds and changes in body weight over time in a large cohort of European adults
AU - Debras, Charlotte
AU - Cordova, Reynalda
AU - Mayén, Ana-Lucia
AU - Maasen, Kim
AU - Knaze, Viktoria
AU - Eussen, Simone Jpm
AU - Schalkwijk, Casper G
AU - Huybrechts, Inge
AU - Tjønneland, Anne
AU - Halkjær, Jytte
AU - Katzke, Verena
AU - Bajracharya, Rashmita
AU - Schulze, Matthias B
AU - Masala, Giovanna
AU - Pala, Valeria
AU - Pasanisi, Fabrizio
AU - Macciotta, Alessandra
AU - Petrova, Dafina
AU - Castañeda, Jazmin
AU - Santiuste, Carmen
AU - Amiano, Pilar
AU - Moreno-Iribas, Conchi
AU - Borné, Yan
AU - Sonestedt, Emily
AU - Johansson, Ingegerd
AU - Esberg, Anders
AU - Aglago, Elom Kouassivi
AU - Jenab, Mazda
AU - Freisling, Heinz
PY - 2024/2/22
Y1 - 2024/2/22
N2 - Dicarbonyl compounds are highly reactive precursors of Advanced Glycation End-products (AGEs), produced endogenously, present in certain foods, and formed during food processing. AGEs contribute to development of adverse metabolic outcomes but health effects of dietary dicarbonyls are largely unexplored. We investigated associations between three dietary dicarbonyl compounds, methylglyoxal (MGO), glyoxal (GO), and 3-deoxyglucosone (3-DG), and body-weight changes in European adults. Dicarbonyl intakes were estimated using food composition database from 263,095 EPIC-PANACEA participants with two body-weight assessments (median follow-up time=5.4y). Associations between dicarbonyls and 5-year body-weight changes were estimated using mixed linear regression models. Stratified analyses by sex, age, and baseline BMI were performed. Risk of becoming overweight/obese was assessed using multivariable-adjusted logistic regression. MGO intake was associated with 5-year body-weight gain of 0.089kg (per 1-SD increase, 95%CI=0.072, 0.107). 3-DG was inversely associated with body-weight change (-0.076kg, -0.094, -0.058). No significant association was observed for GO (0.018kg, -0.002, 0.037). In stratified analyses, GO was associated with body-weight gain among women and older participants (above median of 52.4y). MGO was associated with higher body-weight gain among older participants. 3-DG was inversely associated with body-weight gain among younger and normal-weight participants. MGO was associated with higher risk of becoming overweight/obese, while inverse associations were observed for 3-DG. No associations were observed for GO with overweight/obesity. Dietary dicarbonyls are inconsistently associated with body-weight change among European adults. Further research is needed to clarify the role of these food components in overweight and obesity, their underlying mechanisms, and potential public-health implications.
AB - Dicarbonyl compounds are highly reactive precursors of Advanced Glycation End-products (AGEs), produced endogenously, present in certain foods, and formed during food processing. AGEs contribute to development of adverse metabolic outcomes but health effects of dietary dicarbonyls are largely unexplored. We investigated associations between three dietary dicarbonyl compounds, methylglyoxal (MGO), glyoxal (GO), and 3-deoxyglucosone (3-DG), and body-weight changes in European adults. Dicarbonyl intakes were estimated using food composition database from 263,095 EPIC-PANACEA participants with two body-weight assessments (median follow-up time=5.4y). Associations between dicarbonyls and 5-year body-weight changes were estimated using mixed linear regression models. Stratified analyses by sex, age, and baseline BMI were performed. Risk of becoming overweight/obese was assessed using multivariable-adjusted logistic regression. MGO intake was associated with 5-year body-weight gain of 0.089kg (per 1-SD increase, 95%CI=0.072, 0.107). 3-DG was inversely associated with body-weight change (-0.076kg, -0.094, -0.058). No significant association was observed for GO (0.018kg, -0.002, 0.037). In stratified analyses, GO was associated with body-weight gain among women and older participants (above median of 52.4y). MGO was associated with higher body-weight gain among older participants. 3-DG was inversely associated with body-weight gain among younger and normal-weight participants. MGO was associated with higher risk of becoming overweight/obese, while inverse associations were observed for 3-DG. No associations were observed for GO with overweight/obesity. Dietary dicarbonyls are inconsistently associated with body-weight change among European adults. Further research is needed to clarify the role of these food components in overweight and obesity, their underlying mechanisms, and potential public-health implications.
KW - advanced glycation end products
KW - body weight change
KW - dietary dicarbonyl compounds
KW - obesity
KW - overweight
KW - prospective cohort study
U2 - 10.1017/S0007114524000503
DO - 10.1017/S0007114524000503
M3 - Article
SN - 0007-1145
SP - 1
EP - 13
JO - British Journal of Nutrition
JF - British Journal of Nutrition
ER -