TY - JOUR
T1 - Diet quality indices and dietary patterns are associated with plasma metabolites in colorectal cancer patients
AU - Geijsen, A.J.M.R.
AU - Kok, D.E.
AU - van Zutphen, M.
AU - Keski-Rahkonen, P.
AU - Achaintre, D.
AU - Gicquiau, A.
AU - Gsur, A.
AU - Kruyt, F.M.
AU - Ulrich, C.M.
AU - Weijenberg, M.P.
AU - de Wilt, J.H.W.
AU - Wesselink, E.
AU - Scalbert, A.
AU - Kampman, E.
AU - van Duijnhoven, F.J.B.
PY - 2021/9
Y1 - 2021/9
N2 - Purpose Emerging evidence suggests that diet is linked to survival in colorectal cancer patients, although underlying mechanisms are not fully understood. The aim of this study was to evaluate whether dietary exposures are associated with metabolite concentrations in colorectal cancer patients. Methods Concentrations of 134 metabolites of the Biocrates Absolute(IDQ) p180 kit were quantified in plasma samples collected at diagnosis from 195 stage I-IV colorectal cancer patients. Food frequency questionnaires were used to calculate adherence to the World Cancer Research Fund (WCRF) dietary recommendations and the Dutch Healthy Diet (DHD15) index as well as to construct dietary patterns using Principal Component Analysis. Multivariable linear regression models were used to determine associations between dietary exposures and metabolite concentrations. All models were adjusted for age, sex, body mass index, smoking status, analytical batch, cancer stage, and multiple testing using false discovery rate. Results Participants had a mean (SD) age of 66 (9) years, were mostly men (60%), and mostly diagnosed with stage II and III cancer. For the dietary pattern analyses, Western, Carnivore, and Prudent patterns were identified. Better adherence to the WCRF dietary recommendations was associated with lower concentrations of ten phosphatidylcholines. Higher intake of the Carnivore pattern was associated with higher concentrations of two phosphatidylcholines. The DHD15-index, Western pattern, or Prudent pattern were not associated with metabolite concentrations. Conclusion In the current study, the WCRF dietary score and the Carnivore pattern are associated with phosphatidylcholines. Future research should elucidate the potential relevance of phosphatidylcholine metabolism in the colorectal cancer continuum.
AB - Purpose Emerging evidence suggests that diet is linked to survival in colorectal cancer patients, although underlying mechanisms are not fully understood. The aim of this study was to evaluate whether dietary exposures are associated with metabolite concentrations in colorectal cancer patients. Methods Concentrations of 134 metabolites of the Biocrates Absolute(IDQ) p180 kit were quantified in plasma samples collected at diagnosis from 195 stage I-IV colorectal cancer patients. Food frequency questionnaires were used to calculate adherence to the World Cancer Research Fund (WCRF) dietary recommendations and the Dutch Healthy Diet (DHD15) index as well as to construct dietary patterns using Principal Component Analysis. Multivariable linear regression models were used to determine associations between dietary exposures and metabolite concentrations. All models were adjusted for age, sex, body mass index, smoking status, analytical batch, cancer stage, and multiple testing using false discovery rate. Results Participants had a mean (SD) age of 66 (9) years, were mostly men (60%), and mostly diagnosed with stage II and III cancer. For the dietary pattern analyses, Western, Carnivore, and Prudent patterns were identified. Better adherence to the WCRF dietary recommendations was associated with lower concentrations of ten phosphatidylcholines. Higher intake of the Carnivore pattern was associated with higher concentrations of two phosphatidylcholines. The DHD15-index, Western pattern, or Prudent pattern were not associated with metabolite concentrations. Conclusion In the current study, the WCRF dietary score and the Carnivore pattern are associated with phosphatidylcholines. Future research should elucidate the potential relevance of phosphatidylcholine metabolism in the colorectal cancer continuum.
KW - colorectal cancer patients
KW - diet quality indices
KW - dietary patterns
KW - metabolites
KW - metabolomics
KW - Metabolomics
KW - Diet quality indices
KW - Dietary patterns
KW - Metabolites
KW - Colorectal cancer patients
U2 - 10.1007/s00394-021-02488-1
DO - 10.1007/s00394-021-02488-1
M3 - Article
C2 - 33544207
SN - 1436-6207
VL - 60
SP - 3171
EP - 3184
JO - European Journal of Nutrition
JF - European Journal of Nutrition
IS - 6
ER -