Dickkopf-1 Overexpression in vitro Nominates Candidate Blood Biomarkers Relating to Alzheimer's Disease Pathology

Liu Shi; Laura M. Winchester; Benjamine Y. Liu; Richard Killick; Elena M. Ribe; Sarah Westwood; Alison L. Baird; Noel J. Buckley; Shengjun Hong; Valerija Dobricic; Fabian Kilpert; Andre Franke; Steven Kiddle; Martina Sattlecker; Richard Dobson; Antonio Cuadrado; Abdul Hye; Nicholas J. Ashton; Angharad R. Morgan; Isabelle Bos; Stephanie J. B. Vos; Mara ten Kate; Philip Scheltens; Rik Vandenberghe; Silvy Gabel; Karen Meersmans; Sebastiaan Engelborghs; Ellen E. De Roeck; Kristel Sleegers; Giovanni B. Frisoni; Olivier Blin; Jill C. Richardson; Regis Bordet; Jose L. Molinuevo; Lorena Rami; Anders Wallin; Petronella Kettunen; Magda Tsolaki; Frans Verhey; Alberto Lleo; Daniel Alcolea; Julius Popp; Gwendoline Peyratout; Pablo Martinez-Lage; Mikel Tainta; Peter Johannsen; Charlotte E. Teunissen; Yvonne Freund-Levi; Lutz Frolich; Cristina Legido-Quigley; Frederik Barkhof; Kaj Blennow; Katrine Laura Rasmussen; Borge Gronne Nordestgaard; Ruth Frikke-Schmidt; Sune Fallgaard Nielsen; Hilkka Soininen; Bruno Vellas; Iwona Kloszewska; Patrizia Mecocci; Henrik Zetterberg; B. Paul Morgan; Johannes Streffer; Pieter Jelle Visser; Lars Bertram; Alejo J. Nevado-Holgado; Simon Lovestone

doi:10.3233/JAD-200208

Dickkopf-1 Overexpression in vitro Nominates Candidate Blood Biomarkers Relating to Alzheimer's Disease Pathology

Liu Shi^*, Laura M. Winchester, Benjamine Y. Liu, Richard Killick, Elena M. Ribe, Sarah Westwood, Alison L. Baird, Noel J. Buckley, Shengjun Hong, Valerija Dobricic, Fabian Kilpert, Andre Franke, Steven Kiddle, Martina Sattlecker, Richard Dobson, Antonio Cuadrado, Abdul Hye, Nicholas J. Ashton, Angharad R. Morgan, Isabelle BosStephanie J. B. Vos, Mara ten Kate, Philip Scheltens, Rik Vandenberghe, Silvy Gabel, Karen Meersmans, Sebastiaan Engelborghs, Ellen E. De Roeck, Kristel Sleegers, Giovanni B. Frisoni, Olivier Blin, Jill C. Richardson, Regis Bordet, Jose L. Molinuevo, Lorena Rami, Anders Wallin, Petronella Kettunen, Magda Tsolaki, Frans Verhey, Alberto Lleo, Daniel Alcolea, Julius Popp, Gwendoline Peyratout, Pablo Martinez-Lage, Mikel Tainta, Peter Johannsen, Charlotte E. Teunissen, Yvonne Freund-Levi, Lutz Frolich, Cristina Legido-Quigley, Frederik Barkhof, Kaj Blennow, Katrine Laura Rasmussen, Borge Gronne Nordestgaard, Ruth Frikke-Schmidt, Sune Fallgaard Nielsen, Hilkka Soininen, Bruno Vellas, Iwona Kloszewska, Patrizia Mecocci, Henrik Zetterberg, B. Paul Morgan, Johannes Streffer, Pieter Jelle Visser, Lars Bertram, Alejo J. Nevado-Holgado, Simon Lovestone

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Pages (from-to)	1353-1368
Number of pages	16
Journal	Journal of Alzheimer's Disease
Volume	77
Issue number	3
DOIs	https://doi.org/10.3233/JAD-200208
Publication status	Published - 2020

Keywords

ATN framework
Dickkopf-1
replication
SomaScan
Wnt signaling
BETA-AMYLOID TOXICITY
MENDELIAN RANDOMIZATION
NEURODEGENERATION
DEGENERATION
PATHOGENESIS
METAANALYSIS
ACTIVATION
INDUCTION
PATHWAY
MODELS

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10.3233/JAD-200208Licence: CC BY-NC

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Shi, L., Winchester, L. M., Liu, B. Y., Killick, R., Ribe, E. M., Westwood, S., Baird, A. L., Buckley, N. J., Hong, S., Dobricic, V., Kilpert, F., Franke, A., Kiddle, S., Sattlecker, M., Dobson, R., Cuadrado, A., Hye, A., Ashton, N. J., Morgan, A. R., ... Lovestone, S. (2020). Dickkopf-1 Overexpression in vitro Nominates Candidate Blood Biomarkers Relating to Alzheimer's Disease Pathology. Journal of Alzheimer's Disease, 77(3), 1353-1368. https://doi.org/10.3233/JAD-200208

Shi, Liu ; Winchester, Laura M. ; Liu, Benjamine Y. ; Killick, Richard ; Ribe, Elena M. ; Westwood, Sarah ; Baird, Alison L. ; Buckley, Noel J. ; Hong, Shengjun ; Dobricic, Valerija ; Kilpert, Fabian ; Franke, Andre ; Kiddle, Steven ; Sattlecker, Martina ; Dobson, Richard ; Cuadrado, Antonio ; Hye, Abdul ; Ashton, Nicholas J. ; Morgan, Angharad R. ; Bos, Isabelle ; Vos, Stephanie J. B. ; ten Kate, Mara ; Scheltens, Philip ; Vandenberghe, Rik ; Gabel, Silvy ; Meersmans, Karen ; Engelborghs, Sebastiaan ; De Roeck, Ellen E. ; Sleegers, Kristel ; Frisoni, Giovanni B. ; Blin, Olivier ; Richardson, Jill C. ; Bordet, Regis ; Molinuevo, Jose L. ; Rami, Lorena ; Wallin, Anders ; Kettunen, Petronella ; Tsolaki, Magda ; Verhey, Frans ; Lleo, Alberto ; Alcolea, Daniel ; Popp, Julius ; Peyratout, Gwendoline ; Martinez-Lage, Pablo ; Tainta, Mikel ; Johannsen, Peter ; Teunissen, Charlotte E. ; Freund-Levi, Yvonne ; Frolich, Lutz ; Legido-Quigley, Cristina ; Barkhof, Frederik ; Blennow, Kaj ; Rasmussen, Katrine Laura ; Nordestgaard, Borge Gronne ; Frikke-Schmidt, Ruth ; Nielsen, Sune Fallgaard ; Soininen, Hilkka ; Vellas, Bruno ; Kloszewska, Iwona ; Mecocci, Patrizia ; Zetterberg, Henrik ; Morgan, B. Paul ; Streffer, Johannes ; Visser, Pieter Jelle ; Bertram, Lars ; Nevado-Holgado, Alejo J. ; Lovestone, Simon. / Dickkopf-1 Overexpression in vitro Nominates Candidate Blood Biomarkers Relating to Alzheimer's Disease Pathology. In: Journal of Alzheimer's Disease. 2020 ; Vol. 77, No. 3. pp. 1353-1368.

@article{58e1f81ed02f41bf97581eb28b2f91c5,

title = "Dickkopf-1 Overexpression in vitro Nominates Candidate Blood Biomarkers Relating to Alzheimer's Disease Pathology",

keywords = "ATN framework, Dickkopf-1, replication, SomaScan, Wnt signaling, BETA-AMYLOID TOXICITY, MENDELIAN RANDOMIZATION, NEURODEGENERATION, DEGENERATION, PATHOGENESIS, METAANALYSIS, ACTIVATION, INDUCTION, PATHWAY, MODELS",

author = "Liu Shi and Winchester, {Laura M.} and Liu, {Benjamine Y.} and Richard Killick and Ribe, {Elena M.} and Sarah Westwood and Baird, {Alison L.} and Buckley, {Noel J.} and Shengjun Hong and Valerija Dobricic and Fabian Kilpert and Andre Franke and Steven Kiddle and Martina Sattlecker and Richard Dobson and Antonio Cuadrado and Abdul Hye and Ashton, {Nicholas J.} and Morgan, {Angharad R.} and Isabelle Bos and Vos, {Stephanie J. B.} and {ten Kate}, Mara and Philip Scheltens and Rik Vandenberghe and Silvy Gabel and Karen Meersmans and Sebastiaan Engelborghs and {De Roeck}, {Ellen E.} and Kristel Sleegers and Frisoni, {Giovanni B.} and Olivier Blin and Richardson, {Jill C.} and Regis Bordet and Molinuevo, {Jose L.} and Lorena Rami and Anders Wallin and Petronella Kettunen and Magda Tsolaki and Frans Verhey and Alberto Lleo and Daniel Alcolea and Julius Popp and Gwendoline Peyratout and Pablo Martinez-Lage and Mikel Tainta and Peter Johannsen and Teunissen, {Charlotte E.} and Yvonne Freund-Levi and Lutz Frolich and Cristina Legido-Quigley and Frederik Barkhof and Kaj Blennow and Rasmussen, {Katrine Laura} and Nordestgaard, {Borge Gronne} and Ruth Frikke-Schmidt and Nielsen, {Sune Fallgaard} and Hilkka Soininen and Bruno Vellas and Iwona Kloszewska and Patrizia Mecocci and Henrik Zetterberg and Morgan, {B. Paul} and Johannes Streffer and Visser, {Pieter Jelle} and Lars Bertram and Nevado-Holgado, {Alejo J.} and Simon Lovestone",

year = "2020",

doi = "10.3233/JAD-200208",

language = "English",

volume = "77",

pages = "1353--1368",

journal = "Journal of Alzheimer's Disease",

issn = "1387-2877",

publisher = "IOS Press",

number = "3",

}

Shi, L, Winchester, LM, Liu, BY, Killick, R, Ribe, EM, Westwood, S, Baird, AL, Buckley, NJ, Hong, S, Dobricic, V, Kilpert, F, Franke, A, Kiddle, S, Sattlecker, M, Dobson, R, Cuadrado, A, Hye, A, Ashton, NJ, Morgan, AR, Bos, I, Vos, SJB, ten Kate, M, Scheltens, P, Vandenberghe, R, Gabel, S, Meersmans, K, Engelborghs, S, De Roeck, EE, Sleegers, K, Frisoni, GB, Blin, O, Richardson, JC, Bordet, R, Molinuevo, JL, Rami, L, Wallin, A, Kettunen, P, Tsolaki, M, Verhey, F, Lleo, A, Alcolea, D, Popp, J, Peyratout, G, Martinez-Lage, P, Tainta, M, Johannsen, P, Teunissen, CE, Freund-Levi, Y, Frolich, L, Legido-Quigley, C, Barkhof, F, Blennow, K, Rasmussen, KL, Nordestgaard, BG, Frikke-Schmidt, R, Nielsen, SF, Soininen, H, Vellas, B, Kloszewska, I, Mecocci, P, Zetterberg, H, Morgan, BP, Streffer, J, Visser, PJ, Bertram, L, Nevado-Holgado, AJ & Lovestone, S 2020, 'Dickkopf-1 Overexpression in vitro Nominates Candidate Blood Biomarkers Relating to Alzheimer's Disease Pathology', Journal of Alzheimer's Disease, vol. 77, no. 3, pp. 1353-1368. https://doi.org/10.3233/JAD-200208

Dickkopf-1 Overexpression in vitro Nominates Candidate Blood Biomarkers Relating to Alzheimer's Disease Pathology. / Shi, Liu; Winchester, Laura M.; Liu, Benjamine Y.; Killick, Richard; Ribe, Elena M.; Westwood, Sarah; Baird, Alison L.; Buckley, Noel J.; Hong, Shengjun; Dobricic, Valerija; Kilpert, Fabian; Franke, Andre; Kiddle, Steven; Sattlecker, Martina; Dobson, Richard; Cuadrado, Antonio; Hye, Abdul; Ashton, Nicholas J.; Morgan, Angharad R.; Bos, Isabelle; Vos, Stephanie J. B.; ten Kate, Mara; Scheltens, Philip; Vandenberghe, Rik; Gabel, Silvy; Meersmans, Karen; Engelborghs, Sebastiaan; De Roeck, Ellen E.; Sleegers, Kristel; Frisoni, Giovanni B.; Blin, Olivier; Richardson, Jill C.; Bordet, Regis; Molinuevo, Jose L.; Rami, Lorena; Wallin, Anders; Kettunen, Petronella; Tsolaki, Magda; Verhey, Frans; Lleo, Alberto; Alcolea, Daniel; Popp, Julius; Peyratout, Gwendoline; Martinez-Lage, Pablo; Tainta, Mikel; Johannsen, Peter; Teunissen, Charlotte E.; Freund-Levi, Yvonne; Frolich, Lutz; Legido-Quigley, Cristina; Barkhof, Frederik; Blennow, Kaj; Rasmussen, Katrine Laura; Nordestgaard, Borge Gronne; Frikke-Schmidt, Ruth; Nielsen, Sune Fallgaard; Soininen, Hilkka; Vellas, Bruno; Kloszewska, Iwona; Mecocci, Patrizia; Zetterberg, Henrik; Morgan, B. Paul; Streffer, Johannes; Visser, Pieter Jelle; Bertram, Lars; Nevado-Holgado, Alejo J.; Lovestone, Simon.

In: Journal of Alzheimer's Disease, Vol. 77, No. 3, 2020, p. 1353-1368.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Dickkopf-1 Overexpression in vitro Nominates Candidate Blood Biomarkers Relating to Alzheimer's Disease Pathology

AU - Shi, Liu

AU - Winchester, Laura M.

AU - Liu, Benjamine Y.

AU - Killick, Richard

AU - Ribe, Elena M.

AU - Westwood, Sarah

AU - Baird, Alison L.

AU - Buckley, Noel J.

AU - Hong, Shengjun

AU - Dobricic, Valerija

AU - Kilpert, Fabian

AU - Franke, Andre

AU - Kiddle, Steven

AU - Sattlecker, Martina

AU - Dobson, Richard

AU - Cuadrado, Antonio

AU - Hye, Abdul

AU - Ashton, Nicholas J.

AU - Morgan, Angharad R.

AU - Bos, Isabelle

AU - Vos, Stephanie J. B.

AU - ten Kate, Mara

AU - Scheltens, Philip

AU - Vandenberghe, Rik

AU - Gabel, Silvy

AU - Meersmans, Karen

AU - Engelborghs, Sebastiaan

AU - De Roeck, Ellen E.

AU - Sleegers, Kristel

AU - Frisoni, Giovanni B.

AU - Blin, Olivier

AU - Richardson, Jill C.

AU - Bordet, Regis

AU - Molinuevo, Jose L.

AU - Rami, Lorena

AU - Wallin, Anders

AU - Kettunen, Petronella

AU - Tsolaki, Magda

AU - Verhey, Frans

AU - Lleo, Alberto

AU - Alcolea, Daniel

AU - Popp, Julius

AU - Peyratout, Gwendoline

AU - Martinez-Lage, Pablo

AU - Tainta, Mikel

AU - Johannsen, Peter

AU - Teunissen, Charlotte E.

AU - Freund-Levi, Yvonne

AU - Frolich, Lutz

AU - Legido-Quigley, Cristina

AU - Barkhof, Frederik

AU - Blennow, Kaj

AU - Rasmussen, Katrine Laura

AU - Nordestgaard, Borge Gronne

AU - Frikke-Schmidt, Ruth

AU - Nielsen, Sune Fallgaard

AU - Soininen, Hilkka

AU - Vellas, Bruno

AU - Kloszewska, Iwona

AU - Mecocci, Patrizia

AU - Zetterberg, Henrik

AU - Morgan, B. Paul

AU - Streffer, Johannes

AU - Visser, Pieter Jelle

AU - Bertram, Lars

AU - Nevado-Holgado, Alejo J.

AU - Lovestone, Simon

PY - 2020

Y1 - 2020

KW - ATN framework

KW - Dickkopf-1

KW - replication

KW - SomaScan

KW - Wnt signaling

KW - BETA-AMYLOID TOXICITY

KW - MENDELIAN RANDOMIZATION

KW - NEURODEGENERATION

KW - DEGENERATION

KW - PATHOGENESIS

KW - METAANALYSIS

KW - ACTIVATION

KW - INDUCTION

KW - PATHWAY

KW - MODELS

U2 - 10.3233/JAD-200208

DO - 10.3233/JAD-200208

M3 - Article

VL - 77

SP - 1353

EP - 1368

JO - Journal of Alzheimer's Disease

JF - Journal of Alzheimer's Disease

SN - 1387-2877

IS - 3

ER -