Diabetes mellitus en levercirrose: prognostisch ongunstige combinatie

N. Wlazlo, H.P. Sauerwein, E.J. Schoon, C.D.A. Stehouwer, B. Bravenboer

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- We conducted a literature search to determine the prognostic effect of diabetes in patients with cirrhosis of the liver. We also searched for evidence on diagnosis and treatment of diabetes in these patients.- Insulin resistance occurs in obese patients with cirrhosis due to non-alcoholic steatohepatitis, but also develops in patients with alcoholic or viral cirrhosis. Eventually, 20-40% of patients with cirrhosis have manifest diabetes mellitus.- Diabetes mellitus may accelerate progression of liver fibrosis to cirrhosis and may lead to higher mortality rates among cirrhosis patients, largely due to infections and liver failure.- Treatment of diabetes in patients with chronic liver disease can theoretically improve survival.- In treating such patients, doctors should take into account the reduced clearance of insulin and oral antidiabetic agents in the liver.
Original languageEnglish
Pages (from-to)A2213
JournalNederlands Tijdschrift voor Geneeskunde
Issue number5
Publication statusPublished - 1 Jan 2011

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