Developmental immunotoxicity testing for hazard identification.

I. Tonk

doi:10.26481/dis.20121115it

Developmental immunotoxicity testing for hazard identification.

I. Tonk

Research output: Thesis › Doctoral Thesis › Internal

Abstract

Children can be more sensitive to chemical substances than adults. However, in the current safety evaluation of chemical substances, the specific sensitivity of children is possibly not sufficiently taken into account. This dissertation has established by means of animal studies that the developing immune system during the pre- and post-natal phase is relatively sensitive compared to general parameters of growth and development. The results have contributed to the development of a new international test directive for a generation study with additional immune parameters, which may enable better protection of children against the possible harmful effects of chemical substances.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	Maastricht University
Supervisors/Advisors	van Loveren, Henk, Supervisor Piersma, A., Supervisor, External person de Groot, D., Co-Supervisor, External person
Award date	15 Nov 2012
DOIs	https://doi.org/10.26481/dis.20121115it
Publication status	Published - 1 Jan 2012

Keywords

developmental immunotoxicity
sensitivity in children
hazard identification of chemical substances

Access to Document

10.26481/dis.20121115it

Cite this

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AB - Children can be more sensitive to chemical substances than adults. However, in the current safety evaluation of chemical substances, the specific sensitivity of children is possibly not sufficiently taken into account. This dissertation has established by means of animal studies that the developing immune system during the pre- and post-natal phase is relatively sensitive compared to general parameters of growth and development. The results have contributed to the development of a new international test directive for a generation study with additional immune parameters, which may enable better protection of children against the possible harmful effects of chemical substances.

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