Developmental immunotoxicity testing for hazard identification.

I. Tonk

    Research output: ThesisDoctoral ThesisInternal


    Children can be more sensitive to chemical substances than adults. However, in the current safety evaluation of chemical substances, the specific sensitivity of children is possibly not sufficiently taken into account. This dissertation has established by means of animal studies that the developing immune system during the pre- and post-natal phase is relatively sensitive compared to general parameters of growth and development. The results have contributed to the development of a new international test directive for a generation study with additional immune parameters, which may enable better protection of children against the possible harmful effects of chemical substances.
    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • Maastricht University
    • van Loveren, Henk, Supervisor
    • Piersma, A., Supervisor, External person
    • de Groot, D., Co-Supervisor, External person
    Award date15 Nov 2012
    Publication statusPublished - 1 Jan 2012


    • developmental immunotoxicity
    • sensitivity in children
    • hazard identification of chemical substances

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