@article{3bcd32f7b3144964bfe301fd0a52affd,
title = "Development and validation of a prognostic score for long-term transplant-free survival in autoimmune hepatitis type 1",
abstract = "Background: No prognostic score is currently available for long-term survival in autoimmune hepatitis (AIH) patients. Objective: The aim of this study was to develop and validate such a prognostic score for AIH patients at diagnosis. Methods: The prognostic score was developed using uni- & multivariate Cox regression in a 4-center Dutch cohort and validated in an independent 6-center Belgian cohort. Results: In the derivation cohort of 396 patients 19 liver transplantations (LTs) and 51 deaths occurred (median follow-up 118 months; interquartile range 60–202 months). In multivariate analysis age (hazard ratio [HR] 1.045; p < 0.001), non-caucasian ethnicity (HR 1.897; p = 0.045), cirrhosis (HR 3.266; p < 0.001) and alanine aminotransferase level (HR 0.725; p = 0.003) were significant independent predictors for mortality or LT (C-statistic 0.827; 95% CI 0.790–0.864). In the validation cohort of 408 patients death or LT occurred in 78 patients during a median follow-up of 74 months (interquartile range: 25–142 months). Predicted 5-year event rate did not differ from observed event rate (high risk group 21.5% vs. 15.7% (95% CI: 6.3%–24.2%); moderate risk group 5.8% versus 4.3% (95% CI: 0.0%–9.1%); low risk group 1.9% versus 5.4% (95% CI: 0.0%–11.4%); C-statistic 0.744 [95% CI 0.644–0.844]). Conclusions: A Dutch-Belgian prognostic score for long-term transplant-free survival in AIH patients at diagnosis was developed and validated.",
keywords = "AIH, autoimmune hepatitis, autoimmune liver disease, liver transplantation, long-term survival, mortality, prognostic score, risk stratification, transplant-free survival, validation",
author = "Maaike Biewenga and Verhelst, {Xavier P.D.M.J.} and Baven-Pronk, {Martine A.M.C.} and Hein Putter and {van den Berg}, {Aad P.} and {van Nieuwkerk}, {Karin C.M.J.} and {van Buuren}, {Henk R.} and Gerd Bouma and {de Boer}, {Ynte S.} and Cedric Simoen and Isabelle Colle and Jeoffrey Schouten and Filip Sermon and {van Steenkiste}, Christophe and {van Vlierberghe}, Hans and {van der Meer}, {Adriaan J.} and Frederik Nevens and {van Hoek}, Bart and Drenth, {J. P.H.} and {van Gerven}, {N. M.} and U. Beuers and {van Erpecum}, {K. J.} and {den Ouden}, {J. W.} and A. Bhalla and Brouwer, {J. T.} and Vrolijk, {J. M.} and Koek, {G. H.} and Guichelaar, {M. M.J.} and {van der Wouden}, {E. J.} and {van Meyel}, {J. J.M.} and Baak, {L. C.} and Verdonk, {R. C.} and M. Klemt-Kropp and Verhagen, {M. A.M.T.} and J. Kuijvenhoven and {de Jonge}, {H. M.} and {Dutch Autoimmune Hepatitis Study Group}",
note = "Funding Information: We thank the other members of the Dutch Auto-Immune Hepatitis Study Group for fruitful discussions regarding the manuscript: J.P.H. Drenth (Radboud UMC Nijmegen); N.M. van Gerven (Rode Kruis ziekenhuis; Beverwijk); U. Beuers (AMC Amsterdam); K.J. van Erpecum (UMCU Utrecht); J.W. den Ouden and A. Bhalla (Hagaziekenhuis den Haag); J.T. Brouwer (Reinier de Graaf Gasthuis Delft); J.M. Vrolijk (Rijnstate hospital Arnhem); G.H. Koek (MUMC, Maastricht); M.M.J. Guichelaar (Medisch Spectrum Twente, Enschede); E.J. van der Wouden (Isala hospital Zwolle); J.J.M van Meyel and L.C. Baak (OLVG, Amsterdam); R.C. Verdonk (St. Antonius Hospital Nieuwegein); M. Klemt-Kropp (Noordwest Ziekenhuisgroep Alkmaar); M.A.M.T. Verhagen (Diakonessenhuis, Utrecht); J. Ph. Kuijvenhoven (Spaarne Gasthuis Haarlem); H.M. de Jonge (Jeroen Bosch ziekenhuis den Bosch); MB was supported by unrestricted grants from Zambon Pharma. No other financial support received for this study. Publisher Copyright: {\textcopyright} 2021 The Authors. UEG Journal published by Wiley Periodicals LLC. on behalf of United European Gastroenterology.",
year = "2021",
month = jul,
day = "1",
doi = "10.1002/ueg2.12112",
language = "English",
volume = "9",
pages = "662--671",
journal = "United European Gastroenterology Journal",
issn = "2050-6406",
publisher = "SAGE Publications Inc.",
number = "6",
}