Determinants of exercise-induced oxygen desaturation including pulmonary emphysema in COPD: Results from the ECLIPSE study

Vasileios Andrianopoulos*, Bartolome R. Celli, Frits M. E. Franssen, Victor M. Pinto-Plata, Peter M. A. Calverley, Lowie E. G. W. Vanfleteren, Ioannis Vogiatzis, Jorgen Vestbo, Alvar Agusti, Per S. Bakke, Stephen I. Rennard, William MacNee, Ruth Tal-Singer, Julie C. Yates, Emiel F. M. Wouters, Martijn A. Spruit

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Exercise-induced oxygen desaturation (EID) is related to mortality in patients with chronic obstructive pulmonary disease (COPD). We investigated: (1) the prevalence of EID; (2) the relative-weight of several physiological determinants of EID including pulmonary emphysema, and (3) the relationship of EID with certain patients' clinical characteristics. Data from 2050 COPD patients (age: 63.3 +/- 7.1years; FEV1: 48.7 +/- 15.7%pred.) were analyzed. The occurrence of EID (SpO(2)post = 30 kg/m(2)), impaired FEV1 (
Original languageEnglish
Pages (from-to)87-95
JournalRespiratory Medicine
Publication statusPublished - Oct 2016


  • 6MWD
  • EID
  • ADO index
  • Emphysema
  • Computed tomography
  • Imaging

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