Determinants of bleeding phenotype in adult patients with moderate or severe von Willebrand disease

Eva M. de Wee; Yvonne V. Sanders; Eveline P. Mauser-Bunschoten; Johanna G. van der Bom; Manon E. L. Degenaar-Dujardin; Jeroen Eikenboom; Arja de Goede-Bolder; Britta A. P. Laros-van Gorkom; Karina Meijer; Karly Hamulyak; Marten R. Nijziel; Karin Fijnvandraat; Frank W. G. Leebeek

doi:10.1160/TH12-04-0244

Determinants of bleeding phenotype in adult patients with moderate or severe von Willebrand disease

Eva M. de Wee, Yvonne V. Sanders, Eveline P. Mauser-Bunschoten, Johanna G. van der Bom, Manon E. L. Degenaar-Dujardin, Jeroen Eikenboom, Arja de Goede-Bolder, Britta A. P. Laros-van Gorkom, Karina Meijer, Karly Hamulyak, Marten R. Nijziel, Karin Fijnvandraat, Frank W. G. Leebeek^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

We performed a nation-wide cross-sectional study to evaluate determinants of bleeding symptoms in a large unselected cohort of adults with von Willebrand disease (VWD). VWD patients were included (n=664), based on lowest historically measured VWF:Ag and VWF:Act levels 30 IU/dl. In type 3 patients 1 IU/dl FVIII:C decrease was associated with 0.6 point (95%CI 0.1-1.1) BS increase (p=0.021). In conclusion, in VWD patients the bleeding phenotype is strongly associated with type of VWD and VWF and FVIII levels.

Original language	English
Pages (from-to)	683-692
Journal	Thrombosis and Haemostasis
Volume	108
Issue number	4
DOIs	https://doi.org/10.1160/TH12-04-0244
Publication status	Published - Oct 2012

Keywords

Bleeding
bleeding phenotype
von Willebrand disease
von Willebrand factor

Access to Document

10.1160/TH12-04-0244

Cite this

de Wee, E. M., Sanders, Y. V., Mauser-Bunschoten, E. P., van der Bom, J. G., Degenaar-Dujardin, M. E. L., Eikenboom, J., de Goede-Bolder, A., Laros-van Gorkom, B. A. P., Meijer, K., Hamulyak, K., Nijziel, M. R., Fijnvandraat, K., & Leebeek, F. W. G. (2012). Determinants of bleeding phenotype in adult patients with moderate or severe von Willebrand disease. Thrombosis and Haemostasis, 108(4), 683-692. https://doi.org/10.1160/TH12-04-0244

@article{48d65b04486741df864aadbd86e11bbf,

title = "Determinants of bleeding phenotype in adult patients with moderate or severe von Willebrand disease",

abstract = "We performed a nation-wide cross-sectional study to evaluate determinants of bleeding symptoms in a large unselected cohort of adults with von Willebrand disease (VWD). VWD patients were included (n=664), based on lowest historically measured VWF:Ag and VWF:Act levels 30 IU/dl. In type 3 patients 1 IU/dl FVIII:C decrease was associated with 0.6 point (95%CI 0.1-1.1) BS increase (p=0.021). In conclusion, in VWD patients the bleeding phenotype is strongly associated with type of VWD and VWF and FVIII levels.",

keywords = "Bleeding, bleeding phenotype, von Willebrand disease, von Willebrand factor",

author = "{de Wee}, {Eva M.} and Sanders, {Yvonne V.} and Mauser-Bunschoten, {Eveline P.} and {van der Bom}, {Johanna G.} and Degenaar-Dujardin, {Manon E. L.} and Jeroen Eikenboom and {de Goede-Bolder}, Arja and {Laros-van Gorkom}, {Britta A. P.} and Karina Meijer and Karly Hamulyak and Nijziel, {Marten R.} and Karin Fijnvandraat and Leebeek, {Frank W. G.}",

year = "2012",

month = oct,

doi = "10.1160/TH12-04-0244",

language = "English",

volume = "108",

pages = "683--692",

journal = "Thrombosis and Haemostasis",

issn = "0340-6245",

publisher = "Georg Thieme Verlag",

number = "4",

}

de Wee, EM, Sanders, YV, Mauser-Bunschoten, EP, van der Bom, JG, Degenaar-Dujardin, MEL, Eikenboom, J, de Goede-Bolder, A, Laros-van Gorkom, BAP, Meijer, K, Hamulyak, K, Nijziel, MR, Fijnvandraat, K & Leebeek, FWG 2012, 'Determinants of bleeding phenotype in adult patients with moderate or severe von Willebrand disease', Thrombosis and Haemostasis, vol. 108, no. 4, pp. 683-692. https://doi.org/10.1160/TH12-04-0244

TY - JOUR

T1 - Determinants of bleeding phenotype in adult patients with moderate or severe von Willebrand disease

AU - de Wee, Eva M.

AU - Sanders, Yvonne V.

AU - Mauser-Bunschoten, Eveline P.

AU - van der Bom, Johanna G.

AU - Degenaar-Dujardin, Manon E. L.

AU - Eikenboom, Jeroen

AU - de Goede-Bolder, Arja

AU - Laros-van Gorkom, Britta A. P.

AU - Meijer, Karina

AU - Hamulyak, Karly

AU - Nijziel, Marten R.

AU - Fijnvandraat, Karin

AU - Leebeek, Frank W. G.

PY - 2012/10

Y1 - 2012/10

N2 - We performed a nation-wide cross-sectional study to evaluate determinants of bleeding symptoms in a large unselected cohort of adults with von Willebrand disease (VWD). VWD patients were included (n=664), based on lowest historically measured VWF:Ag and VWF:Act levels 30 IU/dl. In type 3 patients 1 IU/dl FVIII:C decrease was associated with 0.6 point (95%CI 0.1-1.1) BS increase (p=0.021). In conclusion, in VWD patients the bleeding phenotype is strongly associated with type of VWD and VWF and FVIII levels.

AB - We performed a nation-wide cross-sectional study to evaluate determinants of bleeding symptoms in a large unselected cohort of adults with von Willebrand disease (VWD). VWD patients were included (n=664), based on lowest historically measured VWF:Ag and VWF:Act levels 30 IU/dl. In type 3 patients 1 IU/dl FVIII:C decrease was associated with 0.6 point (95%CI 0.1-1.1) BS increase (p=0.021). In conclusion, in VWD patients the bleeding phenotype is strongly associated with type of VWD and VWF and FVIII levels.

KW - Bleeding

KW - bleeding phenotype

KW - von Willebrand disease

KW - von Willebrand factor

U2 - 10.1160/TH12-04-0244

DO - 10.1160/TH12-04-0244

M3 - Article

C2 - 22918553

SN - 0340-6245

VL - 108

SP - 683

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JO - Thrombosis and Haemostasis

JF - Thrombosis and Haemostasis

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