Determinants of bleeding phenotype in adult patients with moderate or severe von Willebrand disease

Eva M. de Wee, Yvonne V. Sanders, Eveline P. Mauser-Bunschoten, Johanna G. van der Bom, Manon E. L. Degenaar-Dujardin, Jeroen Eikenboom, Arja de Goede-Bolder, Britta A. P. Laros-van Gorkom, Karina Meijer, Karly Hamulyak, Marten R. Nijziel, Karin Fijnvandraat, Frank W. G. Leebeek*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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We performed a nation-wide cross-sectional study to evaluate determinants of bleeding symptoms in a large unselected cohort of adults with von Willebrand disease (VWD). VWD patients were included (n=664), based on lowest historically measured VWF:Ag and VWF:Act levels 30 IU/dl. In type 3 patients 1 IU/dl FVIII:C decrease was associated with 0.6 point (95%CI 0.1-1.1) BS increase (p=0.021). In conclusion, in VWD patients the bleeding phenotype is strongly associated with type of VWD and VWF and FVIII levels.
Original languageEnglish
Pages (from-to)683-692
JournalThrombosis and Haemostasis
Issue number4
Publication statusPublished - Oct 2012


  • Bleeding
  • bleeding phenotype
  • von Willebrand disease
  • von Willebrand factor

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