TY - JOUR
T1 - Design, manufacturing and testing of a green non-isocyanate polyurethane prosthetic heart valve
AU - Melo, Sofia F.
AU - Nondonfaz, Alicia
AU - Aqil, Abdelhafid
AU - Pierrard, Anna
AU - Hulin, Alexia
AU - Delierneux, Céline
AU - Ditkowski, Bartosz
AU - Gustin, Maxime
AU - Legrand, Maxime
AU - Tullemans, Bibian M.E.
AU - Brouns, Sanne L.N.
AU - Nchimi, Alain
AU - Carrus, Raoul
AU - Dejosé, Astrid
AU - Heemskerk, Johan W.M.
AU - Kuijpers, Marijke J.E.
AU - Ritter, Jan
AU - Steinseifer, Ulrich
AU - Clauser, Johanna C.
AU - Jérôme, Christine
AU - Lancellotti, Patrizio
AU - Oury, Cécile
N1 - Publisher Copyright:
© 2024 The Royal Society of Chemistry.
PY - 2024/1/1
Y1 - 2024/1/1
N2 - The sole effective treatment for most patients with heart valve disease is valve replacement by implantation of mechanical or biological prostheses. However, mechanical valves represent high risk of thromboembolism, and biological prostheses are prone to early degeneration. In this work, we aim to determine the potential of novel environmentally-friendly non-isocyanate polyurethanes (NIPUs) for manufacturing synthetic prosthetic heart valves. Polyhydroxyurethane (PHU) NIPUs are synthesized via an isocyanate-free route, tested in vitro, and used to produce aortic valves. PHU elastomers reinforced with a polyester mesh show mechanical properties similar to native valve leaflets. These NIPUs do not cause hemolysis. Interestingly, both platelet adhesion and contact activation-induced coagulation are strongly reduced on NIPU surfaces, indicating low thrombogenicity. Fibroblasts and endothelial cells maintain normal growth and shape after indirect contact with NIPUs. Fluid-structure interaction (FSI) allows modeling of the ideal valve design, with minimal shear stress on the leaflets. Injection-molded valves are tested in a pulse duplicator and show ISO-compliant hydrodynamic performance, comparable to clinically-used bioprostheses. Poly(tetrahydrofuran) (PTHF)-NIPU patches do not show any evidence of calcification over a period of 8 weeks. NIPUs are promising sustainable biomaterials for the manufacturing of improved prosthetic valves with low thrombogenicity.
AB - The sole effective treatment for most patients with heart valve disease is valve replacement by implantation of mechanical or biological prostheses. However, mechanical valves represent high risk of thromboembolism, and biological prostheses are prone to early degeneration. In this work, we aim to determine the potential of novel environmentally-friendly non-isocyanate polyurethanes (NIPUs) for manufacturing synthetic prosthetic heart valves. Polyhydroxyurethane (PHU) NIPUs are synthesized via an isocyanate-free route, tested in vitro, and used to produce aortic valves. PHU elastomers reinforced with a polyester mesh show mechanical properties similar to native valve leaflets. These NIPUs do not cause hemolysis. Interestingly, both platelet adhesion and contact activation-induced coagulation are strongly reduced on NIPU surfaces, indicating low thrombogenicity. Fibroblasts and endothelial cells maintain normal growth and shape after indirect contact with NIPUs. Fluid-structure interaction (FSI) allows modeling of the ideal valve design, with minimal shear stress on the leaflets. Injection-molded valves are tested in a pulse duplicator and show ISO-compliant hydrodynamic performance, comparable to clinically-used bioprostheses. Poly(tetrahydrofuran) (PTHF)-NIPU patches do not show any evidence of calcification over a period of 8 weeks. NIPUs are promising sustainable biomaterials for the manufacturing of improved prosthetic valves with low thrombogenicity.
U2 - 10.1039/d3bm01911j
DO - 10.1039/d3bm01911j
M3 - Article
SN - 2047-4830
JO - Biomaterials Science
JF - Biomaterials Science
ER -