Design and recruitment of a large-scale cohort study on prevalence, risk factors and impact evaluation of post-COVID-19 condition and its wider long-term social, mental, and physical health impact: The PRIME post-COVID study

Demi M E Pagen; Céline J A van Bilsen; Stephanie Brinkhues; Chrissy P B Moonen; Maarten Van Herck; Kevin Konings; Casper D J den Heijer; Suhreta Mujakovic; Henriëtte L G Ter Waarbeek; Noortje Bouwmeester-Vincken; Anouk W Vaes; Martijn A Spruit; Christian J P A Hoebe; Nicole H T M Dukers-Muijrers

doi:10.3389/fpubh.2022.1032955

Design and recruitment of a large-scale cohort study on prevalence, risk factors and impact evaluation of post-COVID-19 condition and its wider long-term social, mental, and physical health impact: The PRIME post-COVID study

Demi M E Pagen^*, Céline J A van Bilsen, Stephanie Brinkhues, Chrissy P B Moonen, Maarten Van Herck, Kevin Konings, Casper D J den Heijer, Suhreta Mujakovic, Henriëtte L G Ter Waarbeek, Noortje Bouwmeester-Vincken, Anouk W Vaes, Martijn A Spruit, Christian J P A Hoebe, Nicole H T M Dukers-Muijrers

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND: Persistent symptoms, described as long COVID or post-COVID-19 condition, pose a potential public health problem. Here, the design and recruitment of the PRIME post-COVID study is described. PRIME post-COVID is a large-scale population-based observational study that aims to improve understanding of the occurrence, risk factors, social, physical, mental, emotional, and socioeconomic impact of post-COVID-19 condition.

METHODS: An observational open cohort study was set up, with retrospective and prospective assessments on various health-conditions and health-factors (medical, demographic, social, and behavioral) based on a public health COVID-19 test and by self-report (using online questionnaires in Dutch language). Invited for participation were, as recorded in a public health registry, adults (18 years and older) who were tested for COVID-19 and had a valid Polymerase Chain Reaction (PCR) positive or negative test result, and email address. In November 2021, 61,655 individuals were invited by email to participate, these included all eligible adults who tested PCR positive between 1 June 2020 and 1 November 2021, and a sample of adults who tested negative (2:1), comparable in distribution of age, sex, municipality of residence and year-quarter of testing. New recruitment periods are planned as well. Participants are followed over time by regular follow-up measurements. Data are analyzed using the appropriate data-analyses methods.

DISCUSSION: The PRIME post-COVID study will provide insights into various health-related aspects of post-COVID-19 condition in the context of various stages of the COVID-19 pandemic. Results will inform practical guidance for society, clinical and public health practice for the prevention and care for long-term impact of COVID-19.

TRIAL REGISTRATION CLINICALTRIALSGOV IDENTIFIER: NCT05128695.

Original language	English
Article number	1032955
Pages (from-to)	1032955
Number of pages	10
Journal	Frontiers in Public Health
Volume	10
DOIs	https://doi.org/10.3389/fpubh.2022.1032955
Publication status	Published - 15 Dec 2022

Keywords

Adult
Humans
COVID-19/epidemiology
SARS-CoV-2
Cohort Studies
Prospective Studies
Post-Acute COVID-19 Syndrome
Pandemics/prevention & control
Retrospective Studies
Prevalence
Risk Factors

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Pagen, D. M. E., van Bilsen, C. J. A., Brinkhues, S., Moonen, C. P. B., Van Herck, M., Konings, K., den Heijer, C. D. J., Mujakovic, S., Ter Waarbeek, H. L. G., Bouwmeester-Vincken, N., Vaes, A. W., Spruit, M. A., Hoebe, C. J. P. A., & Dukers-Muijrers, N. H. T. M. (2022). Design and recruitment of a large-scale cohort study on prevalence, risk factors and impact evaluation of post-COVID-19 condition and its wider long-term social, mental, and physical health impact: The PRIME post-COVID study. Frontiers in Public Health, 10, 1032955. Article 1032955. https://doi.org/10.3389/fpubh.2022.1032955

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title = "Design and recruitment of a large-scale cohort study on prevalence, risk factors and impact evaluation of post-COVID-19 condition and its wider long-term social, mental, and physical health impact: The PRIME post-COVID study",

abstract = "BACKGROUND: Persistent symptoms, described as long COVID or post-COVID-19 condition, pose a potential public health problem. Here, the design and recruitment of the PRIME post-COVID study is described. PRIME post-COVID is a large-scale population-based observational study that aims to improve understanding of the occurrence, risk factors, social, physical, mental, emotional, and socioeconomic impact of post-COVID-19 condition.METHODS: An observational open cohort study was set up, with retrospective and prospective assessments on various health-conditions and health-factors (medical, demographic, social, and behavioral) based on a public health COVID-19 test and by self-report (using online questionnaires in Dutch language). Invited for participation were, as recorded in a public health registry, adults (18 years and older) who were tested for COVID-19 and had a valid Polymerase Chain Reaction (PCR) positive or negative test result, and email address. In November 2021, 61,655 individuals were invited by email to participate, these included all eligible adults who tested PCR positive between 1 June 2020 and 1 November 2021, and a sample of adults who tested negative (2:1), comparable in distribution of age, sex, municipality of residence and year-quarter of testing. New recruitment periods are planned as well. Participants are followed over time by regular follow-up measurements. Data are analyzed using the appropriate data-analyses methods.DISCUSSION: The PRIME post-COVID study will provide insights into various health-related aspects of post-COVID-19 condition in the context of various stages of the COVID-19 pandemic. Results will inform practical guidance for society, clinical and public health practice for the prevention and care for long-term impact of COVID-19.TRIAL REGISTRATION CLINICALTRIALSGOV IDENTIFIER: NCT05128695.",

keywords = "Adult, Humans, COVID-19/epidemiology, SARS-CoV-2, Cohort Studies, Prospective Studies, Post-Acute COVID-19 Syndrome, Pandemics/prevention & control, Retrospective Studies, Prevalence, Risk Factors",

author = "Pagen, {Demi M E} and {van Bilsen}, {C{\'e}line J A} and Stephanie Brinkhues and Moonen, {Chrissy P B} and {Van Herck}, Maarten and Kevin Konings and {den Heijer}, {Casper D J} and Suhreta Mujakovic and {Ter Waarbeek}, {Henri{\"e}tte L G} and Noortje Bouwmeester-Vincken and Vaes, {Anouk W} and Spruit, {Martijn A} and Hoebe, {Christian J P A} and Dukers-Muijrers, {Nicole H T M}",

note = "Copyright {\textcopyright} 2022 Pagen, van Bilsen, Brinkhues, Moonen, Van Herck, Konings, den Heijer, Mujakovic, ter Waarbeek, Bouwmeester-Vincken, Vaes, Spruit, Hoebe and Dukers-Muijrers.",

year = "2022",

month = dec,

day = "15",

doi = "10.3389/fpubh.2022.1032955",

language = "English",

volume = "10",

pages = "1032955",

journal = "Frontiers in Public Health",

issn = "2296-2565",

publisher = "Frontiers Media S.A.",

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Pagen, DME , van Bilsen, CJA, Brinkhues, S, Moonen, CPB , Van Herck, M, Konings, K, den Heijer, CDJ, Mujakovic, S, Ter Waarbeek, HLG, Bouwmeester-Vincken, N, Vaes, AW, Spruit, MA , Hoebe, CJPA & Dukers-Muijrers, NHTM 2022, 'Design and recruitment of a large-scale cohort study on prevalence, risk factors and impact evaluation of post-COVID-19 condition and its wider long-term social, mental, and physical health impact: The PRIME post-COVID study', Frontiers in Public Health, vol. 10, 1032955, pp. 1032955. https://doi.org/10.3389/fpubh.2022.1032955

Design and recruitment of a large-scale cohort study on prevalence, risk factors and impact evaluation of post-COVID-19 condition and its wider long-term social, mental, and physical health impact: The PRIME post-COVID study. / Pagen, Demi M E ; van Bilsen, Céline J A; Brinkhues, Stephanie et al.
In: Frontiers in Public Health, Vol. 10, 1032955, 15.12.2022, p. 1032955.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Design and recruitment of a large-scale cohort study on prevalence, risk factors and impact evaluation of post-COVID-19 condition and its wider long-term social, mental, and physical health impact

T2 - The PRIME post-COVID study

AU - Pagen, Demi M E

AU - van Bilsen, Céline J A

AU - Brinkhues, Stephanie

AU - Moonen, Chrissy P B

AU - Van Herck, Maarten

AU - Konings, Kevin

AU - den Heijer, Casper D J

AU - Mujakovic, Suhreta

AU - Ter Waarbeek, Henriëtte L G

AU - Bouwmeester-Vincken, Noortje

AU - Vaes, Anouk W

AU - Spruit, Martijn A

AU - Hoebe, Christian J P A

AU - Dukers-Muijrers, Nicole H T M

PY - 2022/12/15

Y1 - 2022/12/15

N2 - BACKGROUND: Persistent symptoms, described as long COVID or post-COVID-19 condition, pose a potential public health problem. Here, the design and recruitment of the PRIME post-COVID study is described. PRIME post-COVID is a large-scale population-based observational study that aims to improve understanding of the occurrence, risk factors, social, physical, mental, emotional, and socioeconomic impact of post-COVID-19 condition.METHODS: An observational open cohort study was set up, with retrospective and prospective assessments on various health-conditions and health-factors (medical, demographic, social, and behavioral) based on a public health COVID-19 test and by self-report (using online questionnaires in Dutch language). Invited for participation were, as recorded in a public health registry, adults (18 years and older) who were tested for COVID-19 and had a valid Polymerase Chain Reaction (PCR) positive or negative test result, and email address. In November 2021, 61,655 individuals were invited by email to participate, these included all eligible adults who tested PCR positive between 1 June 2020 and 1 November 2021, and a sample of adults who tested negative (2:1), comparable in distribution of age, sex, municipality of residence and year-quarter of testing. New recruitment periods are planned as well. Participants are followed over time by regular follow-up measurements. Data are analyzed using the appropriate data-analyses methods.DISCUSSION: The PRIME post-COVID study will provide insights into various health-related aspects of post-COVID-19 condition in the context of various stages of the COVID-19 pandemic. Results will inform practical guidance for society, clinical and public health practice for the prevention and care for long-term impact of COVID-19.TRIAL REGISTRATION CLINICALTRIALSGOV IDENTIFIER: NCT05128695.

AB - BACKGROUND: Persistent symptoms, described as long COVID or post-COVID-19 condition, pose a potential public health problem. Here, the design and recruitment of the PRIME post-COVID study is described. PRIME post-COVID is a large-scale population-based observational study that aims to improve understanding of the occurrence, risk factors, social, physical, mental, emotional, and socioeconomic impact of post-COVID-19 condition.METHODS: An observational open cohort study was set up, with retrospective and prospective assessments on various health-conditions and health-factors (medical, demographic, social, and behavioral) based on a public health COVID-19 test and by self-report (using online questionnaires in Dutch language). Invited for participation were, as recorded in a public health registry, adults (18 years and older) who were tested for COVID-19 and had a valid Polymerase Chain Reaction (PCR) positive or negative test result, and email address. In November 2021, 61,655 individuals were invited by email to participate, these included all eligible adults who tested PCR positive between 1 June 2020 and 1 November 2021, and a sample of adults who tested negative (2:1), comparable in distribution of age, sex, municipality of residence and year-quarter of testing. New recruitment periods are planned as well. Participants are followed over time by regular follow-up measurements. Data are analyzed using the appropriate data-analyses methods.DISCUSSION: The PRIME post-COVID study will provide insights into various health-related aspects of post-COVID-19 condition in the context of various stages of the COVID-19 pandemic. Results will inform practical guidance for society, clinical and public health practice for the prevention and care for long-term impact of COVID-19.TRIAL REGISTRATION CLINICALTRIALSGOV IDENTIFIER: NCT05128695.

KW - Adult

KW - Humans

KW - COVID-19/epidemiology

KW - SARS-CoV-2

KW - Cohort Studies

KW - Prospective Studies

KW - Post-Acute COVID-19 Syndrome

KW - Pandemics/prevention & control

KW - Retrospective Studies

KW - Prevalence

KW - Risk Factors

U2 - 10.3389/fpubh.2022.1032955

DO - 10.3389/fpubh.2022.1032955

M3 - Article

C2 - 36589958

SN - 2296-2565

VL - 10

SP - 1032955

JO - Frontiers in Public Health

JF - Frontiers in Public Health

M1 - 1032955

ER -

Pagen DME , van Bilsen CJA, Brinkhues S, Moonen CPB , Van Herck M, Konings K et al. Design and recruitment of a large-scale cohort study on prevalence, risk factors and impact evaluation of post-COVID-19 condition and its wider long-term social, mental, and physical health impact: The PRIME post-COVID study. Frontiers in Public Health. 2022 Dec 15;10:1032955. 1032955. doi: 10.3389/fpubh.2022.1032955