Design and rationale of the NetherLands registry of invasive Coronary vasomotor Function Testing (NL-CFT)

C. Crooijmans; T. P. J. Jansen; R. E. Konst; J. Woudstra; Y. Appelman; H. M. den Ruijter; N. C. Onland-Moret; J. G. Meeder; A. M. J. de Vos; V. Paradies; P. Woudstra; K. D. Sjauw; A. van 't Hof; M. Meuwissen; P. Winklerj; E. Boersmal; T. P. van de Hoef; A. H. E. M. Maas; A. C. Dimitriu-Leen; N. van Royen; S. E. Elias-Smale; P. Damman; NL-CFT

doi:10.1016/j.ijcard.2023.02.043

Design and rationale of the NetherLands registry of invasive Coronary vasomotor Function Testing (NL-CFT)

C. Crooijmans, T. P. J. Jansen, R. E. Konst, J. Woudstra, Y. Appelman, H. M. den Ruijter, N. C. Onland-Moret, J. G. Meeder, A. M. J. de Vos, V. Paradies, P. Woudstra, K. D. Sjauw, A. van 't Hof, M. Meuwissen, P. Winklerj, E. Boersmal, T. P. van de Hoef, A. H. E. M. Maas, A. C. Dimitriu-Leen, N. van RoyenS. E. Elias-Smale, P. Damman^*, NL-CFT

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background: Angina without angiographic evidence of obstructive coronary artery disease (ANOCA) is a highly prevalent condition with insufficient pathophysiological knowledge and lack of evidence-based medical therapies. This affects ANOCA patients prognosis, their healthcare utilization and quality of life. In current guidelines, performing a coronary function test (CFT) is recommended to identify a specific vasomotor dysfunction endotype. The NetherLands registry of invasive Coronary vasomotor Function testing (NL-CFT) has been designed to collect data on ANOCA patients undergoing CFT in the Netherlands. Methods: The NL-CFT is a web-based, prospective, observational registry including all consecutive ANOCA patients undergoing clinically indicated CFT in participating centers throughout the Netherlands. Data on medical history, procedural data and (patient reported) outcomes are gathered. The implementation of a common CFT protocol in all participating hospitals promotes an equal diagnostic strategy and ensures representation of the entire ANOCA population. A CFT is performed after ruling out obstructive coronary artery disease. It comprises of both acetylcholine vasoreactivity testing as well as bolus thermodilution assessment of microvascular function. Optionally, continuous thermodilution or Doppler flow measurements can be performed. Participating centers can perform research using own data, or pooled data will be made available upon specific request via a secure digital research environment, after approval of a steering committee. Conclusion: NL-CFT will be an important registry by enabling both observational and registry based (randomized) clinical trials in ANOCA patients undergoing CFT.

Original language	English
Pages (from-to)	1-8
Number of pages	8
Journal	International Journal of Cardiology
Volume	379
Issue number	1
DOIs	https://doi.org/10.1016/j.ijcard.2023.02.043
Publication status	Published - 15 May 2023

Keywords

Coronary function test
Angina with no obstructive coronary artery
disease (ANOCA)
Coronary microvascular dysfunction
Coronary artery spasm
Registry
MICROVASCULAR DYSFUNCTION
STABLE ANGINA
FLOW RESERVE
INTERNATIONAL STANDARDIZATION
MYOCARDIAL-INFARCTION
DIAGNOSTIC-CRITERIA
WORKING GROUP
THERMODILUTION
RESISTANCE
ARTERIES

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Crooijmans, C., Jansen, T. P. J., Konst, R. E., Woudstra, J., Appelman, Y., den Ruijter, H. M., Onland-Moret, N. C., Meeder, J. G., de Vos, A. M. J., Paradies, V., Woudstra, P., Sjauw, K. D., Hof, A. V. ., Meuwissen, M., Winklerj, P., Boersmal, E., Hoef, T. P. V. D., Maas, A. H. E. M., Dimitriu-Leen, A. C., ... NL-CFT (2023). Design and rationale of the NetherLands registry of invasive Coronary vasomotor Function Testing (NL-CFT). International Journal of Cardiology, 379(1), 1-8. https://doi.org/10.1016/j.ijcard.2023.02.043

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title = "Design and rationale of the NetherLands registry of invasive Coronary vasomotor Function Testing (NL-CFT)",

abstract = "Background: Angina without angiographic evidence of obstructive coronary artery disease (ANOCA) is a highly prevalent condition with insufficient pathophysiological knowledge and lack of evidence-based medical therapies. This affects ANOCA patients prognosis, their healthcare utilization and quality of life. In current guidelines, performing a coronary function test (CFT) is recommended to identify a specific vasomotor dysfunction endotype. The NetherLands registry of invasive Coronary vasomotor Function testing (NL-CFT) has been designed to collect data on ANOCA patients undergoing CFT in the Netherlands. Methods: The NL-CFT is a web-based, prospective, observational registry including all consecutive ANOCA patients undergoing clinically indicated CFT in participating centers throughout the Netherlands. Data on medical history, procedural data and (patient reported) outcomes are gathered. The implementation of a common CFT protocol in all participating hospitals promotes an equal diagnostic strategy and ensures representation of the entire ANOCA population. A CFT is performed after ruling out obstructive coronary artery disease. It comprises of both acetylcholine vasoreactivity testing as well as bolus thermodilution assessment of microvascular function. Optionally, continuous thermodilution or Doppler flow measurements can be performed. Participating centers can perform research using own data, or pooled data will be made available upon specific request via a secure digital research environment, after approval of a steering committee. Conclusion: NL-CFT will be an important registry by enabling both observational and registry based (randomized) clinical trials in ANOCA patients undergoing CFT.",

keywords = "Coronary function test, Angina with no obstructive coronary artery, disease (ANOCA), Coronary microvascular dysfunction, Coronary artery spasm, Registry, MICROVASCULAR DYSFUNCTION, STABLE ANGINA, FLOW RESERVE, INTERNATIONAL STANDARDIZATION, MYOCARDIAL-INFARCTION, DIAGNOSTIC-CRITERIA, WORKING GROUP, THERMODILUTION, RESISTANCE, ARTERIES",

author = "C. Crooijmans and Jansen, {T. P. J.} and Konst, {R. E.} and J. Woudstra and Y. Appelman and {den Ruijter}, {H. M.} and Onland-Moret, {N. C.} and Meeder, {J. G.} and {de Vos}, {A. M. J.} and V. Paradies and P. Woudstra and Sjauw, {K. D.} and Hof, {A. van 't} and M. Meuwissen and P. Winklerj and E. Boersmal and Hoef, {T. P. van de} and Maas, {A. H. E. M.} and Dimitriu-Leen, {A. C.} and {van Royen}, N. and Elias-Smale, {S. E.} and P. Damman and NL-CFT",

year = "2023",

month = may,

day = "15",

doi = "10.1016/j.ijcard.2023.02.043",

language = "English",

volume = "379",

pages = "1--8",

journal = "International Journal of Cardiology",

issn = "0167-5273",

publisher = "Elsevier Ireland Ltd",

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Crooijmans, C, Jansen, TPJ, Konst, RE, Woudstra, J, Appelman, Y, den Ruijter, HM, Onland-Moret, NC, Meeder, JG, de Vos, AMJ, Paradies, V, Woudstra, P, Sjauw, KD, Hof, AV, Meuwissen, M, Winklerj, P, Boersmal, E, Hoef, TPVD, Maas, AHEM, Dimitriu-Leen, AC, van Royen, N, Elias-Smale, SE, Damman, P & NL-CFT 2023, 'Design and rationale of the NetherLands registry of invasive Coronary vasomotor Function Testing (NL-CFT)', International Journal of Cardiology, vol. 379, no. 1, pp. 1-8. https://doi.org/10.1016/j.ijcard.2023.02.043

TY - JOUR

T1 - Design and rationale of the NetherLands registry of invasive Coronary vasomotor Function Testing (NL-CFT)

AU - Crooijmans, C.

AU - Jansen, T. P. J.

AU - Konst, R. E.

AU - Woudstra, J.

AU - Appelman, Y.

AU - den Ruijter, H. M.

AU - Onland-Moret, N. C.

AU - Meeder, J. G.

AU - de Vos, A. M. J.

AU - Paradies, V.

AU - Woudstra, P.

AU - Sjauw, K. D.

AU - Hof, A. van 't

AU - Meuwissen, M.

AU - Winklerj, P.

AU - Boersmal, E.

AU - Hoef, T. P. van de

AU - Maas, A. H. E. M.

AU - Dimitriu-Leen, A. C.

AU - van Royen, N.

AU - Elias-Smale, S. E.

AU - Damman, P.

AU - NL-CFT

PY - 2023/5/15

Y1 - 2023/5/15

N2 - Background: Angina without angiographic evidence of obstructive coronary artery disease (ANOCA) is a highly prevalent condition with insufficient pathophysiological knowledge and lack of evidence-based medical therapies. This affects ANOCA patients prognosis, their healthcare utilization and quality of life. In current guidelines, performing a coronary function test (CFT) is recommended to identify a specific vasomotor dysfunction endotype. The NetherLands registry of invasive Coronary vasomotor Function testing (NL-CFT) has been designed to collect data on ANOCA patients undergoing CFT in the Netherlands. Methods: The NL-CFT is a web-based, prospective, observational registry including all consecutive ANOCA patients undergoing clinically indicated CFT in participating centers throughout the Netherlands. Data on medical history, procedural data and (patient reported) outcomes are gathered. The implementation of a common CFT protocol in all participating hospitals promotes an equal diagnostic strategy and ensures representation of the entire ANOCA population. A CFT is performed after ruling out obstructive coronary artery disease. It comprises of both acetylcholine vasoreactivity testing as well as bolus thermodilution assessment of microvascular function. Optionally, continuous thermodilution or Doppler flow measurements can be performed. Participating centers can perform research using own data, or pooled data will be made available upon specific request via a secure digital research environment, after approval of a steering committee. Conclusion: NL-CFT will be an important registry by enabling both observational and registry based (randomized) clinical trials in ANOCA patients undergoing CFT.

AB - Background: Angina without angiographic evidence of obstructive coronary artery disease (ANOCA) is a highly prevalent condition with insufficient pathophysiological knowledge and lack of evidence-based medical therapies. This affects ANOCA patients prognosis, their healthcare utilization and quality of life. In current guidelines, performing a coronary function test (CFT) is recommended to identify a specific vasomotor dysfunction endotype. The NetherLands registry of invasive Coronary vasomotor Function testing (NL-CFT) has been designed to collect data on ANOCA patients undergoing CFT in the Netherlands. Methods: The NL-CFT is a web-based, prospective, observational registry including all consecutive ANOCA patients undergoing clinically indicated CFT in participating centers throughout the Netherlands. Data on medical history, procedural data and (patient reported) outcomes are gathered. The implementation of a common CFT protocol in all participating hospitals promotes an equal diagnostic strategy and ensures representation of the entire ANOCA population. A CFT is performed after ruling out obstructive coronary artery disease. It comprises of both acetylcholine vasoreactivity testing as well as bolus thermodilution assessment of microvascular function. Optionally, continuous thermodilution or Doppler flow measurements can be performed. Participating centers can perform research using own data, or pooled data will be made available upon specific request via a secure digital research environment, after approval of a steering committee. Conclusion: NL-CFT will be an important registry by enabling both observational and registry based (randomized) clinical trials in ANOCA patients undergoing CFT.

KW - Coronary function test

KW - Angina with no obstructive coronary artery

KW - disease (ANOCA)

KW - Coronary microvascular dysfunction

KW - Coronary artery spasm

KW - Registry

KW - MICROVASCULAR DYSFUNCTION

KW - STABLE ANGINA

KW - FLOW RESERVE

KW - INTERNATIONAL STANDARDIZATION

KW - MYOCARDIAL-INFARCTION

KW - DIAGNOSTIC-CRITERIA

KW - WORKING GROUP

KW - THERMODILUTION

KW - RESISTANCE

KW - ARTERIES

U2 - 10.1016/j.ijcard.2023.02.043

DO - 10.1016/j.ijcard.2023.02.043

M3 - Article

C2 - 36863419

SN - 0167-5273

VL - 379

SP - 1

EP - 8

JO - International Journal of Cardiology

JF - International Journal of Cardiology

IS - 1

ER -