Deregulation of cap-dependent mRNA translation increases tumour radiosensitivity through reduction of the hypoxic fraction

Kasper M. A. Rouschop; Ludwig Dubois; Marco B. E. Schaaf; Twan van den Beucken; Natasja Lieuwes; Tom G. H. Keulers; Kim G. M. Savelkouls; Johan Bussink; Albert J. van der Kogel; Marianne Koritzinsky; Bradly G. Wouters

doi:10.1016/j.radonc.2011.05.047

Deregulation of cap-dependent mRNA translation increases tumour radiosensitivity through reduction of the hypoxic fraction

Kasper M. A. Rouschop^*, Ludwig Dubois, Marco B. E. Schaaf, Twan van den Beucken, Natasja Lieuwes, Tom G. H. Keulers, Kim G. M. Savelkouls, Johan Bussink, Albert J. van der Kogel, Marianne Koritzinsky, Bradly G. Wouters

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

20 Citations (Web of Science)

9 Downloads (Pure)

Original language	English
Pages (from-to)	385-391
Journal	Radiotherapy and Oncology
Volume	99
Issue number	3
DOIs	https://doi.org/10.1016/j.radonc.2011.05.047
Publication status	Published - Jun 2011

Keywords

eIF4E
mTOR
Hypoxia
Necrosis
Irradiation

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10.1016/j.radonc.2011.05.047

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Cite this

Rouschop, K. M. A., Dubois, L., Schaaf, M. B. E., van den Beucken, T., Lieuwes, N., Keulers, T. G. H., Savelkouls, K. G. M., Bussink, J., van der Kogel, A. J., Koritzinsky, M., & Wouters, B. G. (2011). Deregulation of cap-dependent mRNA translation increases tumour radiosensitivity through reduction of the hypoxic fraction. Radiotherapy and Oncology, 99(3), 385-391. https://doi.org/10.1016/j.radonc.2011.05.047

Rouschop, Kasper M. A. ; Dubois, Ludwig ; Schaaf, Marco B. E. ; van den Beucken, Twan ; Lieuwes, Natasja ; Keulers, Tom G. H. ; Savelkouls, Kim G. M. ; Bussink, Johan ; van der Kogel, Albert J. ; Koritzinsky, Marianne ; Wouters, Bradly G. / Deregulation of cap-dependent mRNA translation increases tumour radiosensitivity through reduction of the hypoxic fraction. In: Radiotherapy and Oncology. 2011 ; Vol. 99, No. 3. pp. 385-391.

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title = "Deregulation of cap-dependent mRNA translation increases tumour radiosensitivity through reduction of the hypoxic fraction",

keywords = "eIF4E, mTOR, Hypoxia, Necrosis, Irradiation",

author = "Rouschop, {Kasper M. A.} and Ludwig Dubois and Schaaf, {Marco B. E.} and {van den Beucken}, Twan and Natasja Lieuwes and Keulers, {Tom G. H.} and Savelkouls, {Kim G. M.} and Johan Bussink and {van der Kogel}, {Albert J.} and Marianne Koritzinsky and Wouters, {Bradly G.}",

year = "2011",

month = jun,

doi = "10.1016/j.radonc.2011.05.047",

language = "English",

volume = "99",

pages = "385--391",

journal = "Radiotherapy and Oncology",

issn = "0167-8140",

publisher = "Elsevier Ireland Ltd",

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}

Rouschop, KMA , Dubois, L, Schaaf, MBE, van den Beucken, T , Lieuwes, N , Keulers, TGH , Savelkouls, KGM, Bussink, J, van der Kogel, AJ, Koritzinsky, M & Wouters, BG 2011, 'Deregulation of cap-dependent mRNA translation increases tumour radiosensitivity through reduction of the hypoxic fraction', Radiotherapy and Oncology, vol. 99, no. 3, pp. 385-391. https://doi.org/10.1016/j.radonc.2011.05.047

Deregulation of cap-dependent mRNA translation increases tumour radiosensitivity through reduction of the hypoxic fraction. / Rouschop, Kasper M. A.; Dubois, Ludwig; Schaaf, Marco B. E.; van den Beucken, Twan ; Lieuwes, Natasja ; Keulers, Tom G. H.; Savelkouls, Kim G. M.; Bussink, Johan; van der Kogel, Albert J.; Koritzinsky, Marianne; Wouters, Bradly G.

In: Radiotherapy and Oncology, Vol. 99, No. 3, 06.2011, p. 385-391.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Deregulation of cap-dependent mRNA translation increases tumour radiosensitivity through reduction of the hypoxic fraction

AU - Rouschop, Kasper M. A.

AU - Dubois, Ludwig

AU - Schaaf, Marco B. E.

AU - van den Beucken, Twan

AU - Lieuwes, Natasja

AU - Keulers, Tom G. H.

AU - Savelkouls, Kim G. M.

AU - Bussink, Johan

AU - van der Kogel, Albert J.

AU - Koritzinsky, Marianne

AU - Wouters, Bradly G.

PY - 2011/6

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KW - eIF4E

KW - mTOR

KW - Hypoxia

KW - Necrosis

KW - Irradiation

U2 - 10.1016/j.radonc.2011.05.047

DO - 10.1016/j.radonc.2011.05.047

M3 - Article

C2 - 21665307

VL - 99

SP - 385

EP - 391

JO - Radiotherapy and Oncology

JF - Radiotherapy and Oncology

SN - 0167-8140

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