Depressive Symptoms and Mortality in Patients After Kidney Transplantation: A Prospective Prevalent Cohort Study

Marta Novak*, Miklos Zsolt Molnar, Lilla Szeifert, Agnes Zsofia Kovacs, Eszter Panna Vamos, Rezso Zoller, Andras Keszei, Istvan Mucsi

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Objective: To analyze in a prospective cohort study if depressive symptoms are an independent predictor of mortality in kidney transplant recipients. Methods: Data from 840 transplanted patients followed at a single outpatient transplant center were analyzed. Sociodemographic parameters and clinical data were collected at enrollment (between August 2002 and February 2003). Participants completed the Center for Epidemiologic Studies-Depression (CES-D) scale. Depression was defined as CES-D score of >= 18. Data on 5-year outcomes (death censored graft loss or mortality) were collected. Results: The prevalence of depression was 22%. Mortality was higher (21% versus 13%; p = .004) in patients with versus without depression. In a multivariate Cox proportional hazard model, both the baseline CES-D score (hazard ratio(for each 1-point increase) = 1.02; 95% confidence interval, 1.00-1.04) and the presence of depression at baseline (hazard ratio(presence) = 1.66; 95% confidence interval, 1.12-2.47) were significantly associated with mortality. The baseline CES-D score also significantly predicted death censored graft loss (hazard ratio(for each 1-point increase) = 1.03; 95% confidence interval, 1.01-1.05). Conclusion: Depressive symptoms are an independent predictor of mortality in kidney transplanted patients.
Original languageEnglish
Pages (from-to)527-534
JournalPsychosomatic Medicine
Issue number6
Publication statusPublished - 2010


  • depression
  • mortality
  • kidney transplantation

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