Dementia prevention: The potential long-term cost-effectiveness of the FINGER prevention program

Anders Wimo; Ron Handels; Riitta Antikainen; Maria Eriksdotter; Linus Jönsson; Martin Knapp; Jenni Kulmala; Tiina Laatikainen; Jenni Lehtisalo; Markku Peltonen; Anders Sköldunger; Hilkka Soininen; Alina Solomon; Timo Strandberg; Jaakko Tuomilehto; Tiia Ngandu; Miia Kivipelto

doi:10.1002/alz.12698

Dementia prevention: The potential long-term cost-effectiveness of the FINGER prevention program

Anders Wimo^*, Ron Handels, Riitta Antikainen, Maria Eriksdotter, Linus Jönsson, Martin Knapp, Jenni Kulmala, Tiina Laatikainen, Jenni Lehtisalo, Markku Peltonen, Anders Sköldunger, Hilkka Soininen, Alina Solomon, Timo Strandberg, Jaakko Tuomilehto, Tiia Ngandu, Miia Kivipelto

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

INTRODUCTION: The aim of this study was to estimate the potential cost-effectiveness of the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) program.

METHODS: A life-time Markov model with societal perspective, simulating a cohort of people at risk of dementia reflecting usual care and the FINGER program.

RESULTS: Costs were 1,653,275 and 1,635,346 SEK and quality-adjusted life years (QALYs) were 8.636 and 8.679 for usual care and the FINGER program, respectively, resulting in savings of 16,928 SEK (2023 US$) and 0.043 QALY gains per person, supporting extended dominance for the FINGER program. A total of 1623 dementia cases were avoided with 0.17 fewer person-years living with dementia. The sensitivity analysis confirmed the conclusions in most scenarios.

DISCUSSION: The model provides support that programs like FINGER have the potential to be cost-effective in preventing dementia. Results at the individual level are rather modest, but the societal benefits can be substantial because of the large potential target population.

Original language	English
Pages (from-to)	999-1008
Number of pages	10
Journal	Alzheimer's & Dementia
Volume	19
Issue number	3
Early online date	16 Jul 2022
DOIs	https://doi.org/10.1002/alz.12698
Publication status	Published - Mar 2023

Keywords

ALZHEIMERS-DISEASE
CARDIOVASCULAR-DISEASE
COGNITIVE IMPAIRMENT
DESIGN
FINGER
FINNISH GERIATRIC INTERVENTION
IMPACT
MORBIDITY
MORTALITY
PREDICTION
RISK-FACTORS
cost effectiveness
costs
dementia
health economic simulation
prevention

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Wimo, A., Handels, R., Antikainen, R., Eriksdotter, M., Jönsson, L., Knapp, M., Kulmala, J., Laatikainen, T., Lehtisalo, J., Peltonen, M., Sköldunger, A., Soininen, H., Solomon, A., Strandberg, T., Tuomilehto, J., Ngandu, T., & Kivipelto, M. (2023). Dementia prevention: The potential long-term cost-effectiveness of the FINGER prevention program. Alzheimer's & Dementia, 19(3), 999-1008. https://doi.org/10.1002/alz.12698

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title = "Dementia prevention: The potential long-term cost-effectiveness of the FINGER prevention program",

abstract = "INTRODUCTION: The aim of this study was to estimate the potential cost-effectiveness of the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) program.METHODS: A life-time Markov model with societal perspective, simulating a cohort of people at risk of dementia reflecting usual care and the FINGER program.RESULTS: Costs were 1,653,275 and 1,635,346 SEK and quality-adjusted life years (QALYs) were 8.636 and 8.679 for usual care and the FINGER program, respectively, resulting in savings of 16,928 SEK (2023 US$) and 0.043 QALY gains per person, supporting extended dominance for the FINGER program. A total of 1623 dementia cases were avoided with 0.17 fewer person-years living with dementia. The sensitivity analysis confirmed the conclusions in most scenarios.DISCUSSION: The model provides support that programs like FINGER have the potential to be cost-effective in preventing dementia. Results at the individual level are rather modest, but the societal benefits can be substantial because of the large potential target population.",

keywords = "ALZHEIMERS-DISEASE, CARDIOVASCULAR-DISEASE, COGNITIVE IMPAIRMENT, DESIGN, FINGER, FINNISH GERIATRIC INTERVENTION, IMPACT, MORBIDITY, MORTALITY, PREDICTION, RISK-FACTORS, cost effectiveness, costs, dementia, health economic simulation, prevention",

author = "Anders Wimo and Ron Handels and Riitta Antikainen and Maria Eriksdotter and Linus J{\"o}nsson and Martin Knapp and Jenni Kulmala and Tiina Laatikainen and Jenni Lehtisalo and Markku Peltonen and Anders Sk{\"o}ldunger and Hilkka Soininen and Alina Solomon and Timo Strandberg and Jaakko Tuomilehto and Tiia Ngandu and Miia Kivipelto",

note = "{\textcopyright} 2022 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.",

year = "2023",

month = mar,

doi = "10.1002/alz.12698",

language = "English",

volume = "19",

pages = "999--1008",

journal = "Alzheimer's & Dementia",

issn = "1552-5260",

publisher = "John Wiley & Sons Inc.",

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Wimo, A, Handels, R, Antikainen, R, Eriksdotter, M, Jönsson, L, Knapp, M, Kulmala, J, Laatikainen, T, Lehtisalo, J, Peltonen, M, Sköldunger, A, Soininen, H, Solomon, A, Strandberg, T, Tuomilehto, J, Ngandu, T & Kivipelto, M 2023, 'Dementia prevention: The potential long-term cost-effectiveness of the FINGER prevention program', Alzheimer's & Dementia, vol. 19, no. 3, pp. 999-1008. https://doi.org/10.1002/alz.12698

TY - JOUR

T1 - Dementia prevention

T2 - The potential long-term cost-effectiveness of the FINGER prevention program

AU - Wimo, Anders

AU - Handels, Ron

AU - Antikainen, Riitta

AU - Eriksdotter, Maria

AU - Jönsson, Linus

AU - Knapp, Martin

AU - Kulmala, Jenni

AU - Laatikainen, Tiina

AU - Lehtisalo, Jenni

AU - Peltonen, Markku

AU - Sköldunger, Anders

AU - Soininen, Hilkka

AU - Solomon, Alina

AU - Strandberg, Timo

AU - Tuomilehto, Jaakko

AU - Ngandu, Tiia

AU - Kivipelto, Miia

PY - 2023/3

Y1 - 2023/3

N2 - INTRODUCTION: The aim of this study was to estimate the potential cost-effectiveness of the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) program.METHODS: A life-time Markov model with societal perspective, simulating a cohort of people at risk of dementia reflecting usual care and the FINGER program.RESULTS: Costs were 1,653,275 and 1,635,346 SEK and quality-adjusted life years (QALYs) were 8.636 and 8.679 for usual care and the FINGER program, respectively, resulting in savings of 16,928 SEK (2023 US$) and 0.043 QALY gains per person, supporting extended dominance for the FINGER program. A total of 1623 dementia cases were avoided with 0.17 fewer person-years living with dementia. The sensitivity analysis confirmed the conclusions in most scenarios.DISCUSSION: The model provides support that programs like FINGER have the potential to be cost-effective in preventing dementia. Results at the individual level are rather modest, but the societal benefits can be substantial because of the large potential target population.

AB - INTRODUCTION: The aim of this study was to estimate the potential cost-effectiveness of the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) program.METHODS: A life-time Markov model with societal perspective, simulating a cohort of people at risk of dementia reflecting usual care and the FINGER program.RESULTS: Costs were 1,653,275 and 1,635,346 SEK and quality-adjusted life years (QALYs) were 8.636 and 8.679 for usual care and the FINGER program, respectively, resulting in savings of 16,928 SEK (2023 US$) and 0.043 QALY gains per person, supporting extended dominance for the FINGER program. A total of 1623 dementia cases were avoided with 0.17 fewer person-years living with dementia. The sensitivity analysis confirmed the conclusions in most scenarios.DISCUSSION: The model provides support that programs like FINGER have the potential to be cost-effective in preventing dementia. Results at the individual level are rather modest, but the societal benefits can be substantial because of the large potential target population.

KW - ALZHEIMERS-DISEASE

KW - CARDIOVASCULAR-DISEASE

KW - COGNITIVE IMPAIRMENT

KW - DESIGN

KW - FINGER

KW - FINNISH GERIATRIC INTERVENTION

KW - IMPACT

KW - MORBIDITY

KW - MORTALITY

KW - PREDICTION

KW - RISK-FACTORS

KW - cost effectiveness

KW - costs

KW - dementia

KW - health economic simulation

KW - prevention

U2 - 10.1002/alz.12698

DO - 10.1002/alz.12698

M3 - Article

C2 - 35841619

SN - 1552-5260

VL - 19

SP - 999

EP - 1008

JO - Alzheimer's & Dementia

JF - Alzheimer's & Dementia

IS - 3

ER -

Dementia prevention: The potential long-term cost-effectiveness of the FINGER prevention program

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Keywords

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