Delusional and Psychotic Disorders in Juvenile Myotonic Dystrophy Type-1

Delphine Jacobs*, Diane Willekens, Christine de Die-Smulders, Jean-Pierre Frijns, Jean Steyaert

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Web of Science)

Abstract

We investigated the clinically derived hypothesis of a relatively high incidence of delusional and psychotic disorders in adolescents with juvenile Myotonic Dystrophy type-1 (DM1). Twenty-seven subjects of age 16-25 with juvenile DM1 and their parents were invited to have a clinical psychiatric interview, and to complete an ASEBA behavior checklist (YSR, ASR, CBCL, and ABCL). We diagnosed a Delusional Disorder in 19% of our patients and a Psychotic Disorder not otherwise specified in another 19%. These two groups of patients had a significantly worse level of clinically defined general functioning. It is clinically relevant to investigate in patients with juvenile DM the symptom of delusions and the presence of a delusional and psychotic disorder, and to consider the presence of juvenile DM in youngsters presenting with such a thought disorder. These disorders compromise the general functioning of the subjects and are often to some extent treatable. (C) 2017 Wiley Periodicals, Inc.

Original languageEnglish
Pages (from-to)359-366
Number of pages8
JournalAmerican Journal of Medical Genetics Part B-neuropsychiatric Genetics
Volume174
Issue number4
DOIs
Publication statusPublished - Jun 2017

Keywords

  • muscular dystrophy
  • juvenile myotonic disorder
  • delusional disorder
  • psychotic disorder
  • psychosocial functioning
  • UNSTABLE CTG REPEAT
  • PERSONALITY-PATTERNS
  • MUSCULAR-DYSTROPHY
  • CHILDHOOD TYPE
  • DEPRESSION
  • PHENOTYPE
  • EXPANSION
  • MYOPATHY
  • PROFILE
  • GENE

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