TY - JOUR
T1 - Deferring diagnostic evaluation for suspected deep venous thrombosis using a single dose of anticoagulant
T2 - Real-world data from a regionwide care pathway
AU - Luu, Inge H.Y.
AU - Mostard, Guy J.M.
AU - van Mil, Dominique
AU - van Berlo, Marlon H.W.
AU - Lobbes, Marc B.I.
AU - Külcü, Kemal
AU - Cate, Hugo ten
AU - Peeters, Jos
AU - Palmen, Jan
AU - Buijs, Jacqueline
AU - Jie, Kon Siong G.
AU - van Kampen, Roel J.W.
AU - van Twist, Daan J.L.
N1 - Funding Information:
The implementation of this regionwide DVT care pathway was a collaborate effort. The authors therefore would like to thank all GPs and the Department of Medical Imaging of Zuyderland Medical Center for their efforts.
Publisher Copyright:
© 2023 European Federation of Internal Medicine
PY - 2024/4
Y1 - 2024/4
N2 - Background: Patients with suspected deep venous thrombosis (DVT) are typically referred to the emergency department (ED) for immediate evaluation. However, this often contributes to ED overcrowding and necessitates round-the-clock sonographic examinations. Therefore, we implemented a regionwide care pathway for deferring diagnostic workup of suspected DVT until the following day. Patients receive a single anticoagulant dose from their general practitioner (GP) to prevent progression of DVT in the interval between referral and diagnostic evaluation. The next day, patients undergo comprehensive evaluation at our outpatient DVT clinic, including venous ultrasound. This retrospective study aims to provide real-world data on the safety of this care pathway regarding the occurrence of bleeding complications and pulmonary embolism (PE). Methods: We included all GP-referred patients with suspected DVT in 2018 and 2019. Patients with absolute contraindications to deferred evaluation or anticoagulation were excluded. The primary endpoint was the occurrence of bleeding complications. Secondary endpoints included PE events and all-cause mortality within seven days following DVT evaluation. Results: Among 1,024 included patients, DVT was confirmed in 238 patients (23.2%) and superficial thrombophlebitis in 98 patients (9.6%). No bleeding events were recorded in patients in whom DVT was ruled out. PE was confirmed in eight patients on the same day as DVT evaluation (0.8%, 95%CI 0.4–1.6) and in six patients within seven days following DVT evaluation (0.6%, 0.2–1.3%). No deaths occurred during this timeframe. Conclusion: This real-world study observed a very low incidence of bleeding complications and PE events, indicating that this care pathway of deferred DVT workup is safe and may offer a more streamlined diagnostic approach for patients with suspected DVT.
AB - Background: Patients with suspected deep venous thrombosis (DVT) are typically referred to the emergency department (ED) for immediate evaluation. However, this often contributes to ED overcrowding and necessitates round-the-clock sonographic examinations. Therefore, we implemented a regionwide care pathway for deferring diagnostic workup of suspected DVT until the following day. Patients receive a single anticoagulant dose from their general practitioner (GP) to prevent progression of DVT in the interval between referral and diagnostic evaluation. The next day, patients undergo comprehensive evaluation at our outpatient DVT clinic, including venous ultrasound. This retrospective study aims to provide real-world data on the safety of this care pathway regarding the occurrence of bleeding complications and pulmonary embolism (PE). Methods: We included all GP-referred patients with suspected DVT in 2018 and 2019. Patients with absolute contraindications to deferred evaluation or anticoagulation were excluded. The primary endpoint was the occurrence of bleeding complications. Secondary endpoints included PE events and all-cause mortality within seven days following DVT evaluation. Results: Among 1,024 included patients, DVT was confirmed in 238 patients (23.2%) and superficial thrombophlebitis in 98 patients (9.6%). No bleeding events were recorded in patients in whom DVT was ruled out. PE was confirmed in eight patients on the same day as DVT evaluation (0.8%, 95%CI 0.4–1.6) and in six patients within seven days following DVT evaluation (0.6%, 0.2–1.3%). No deaths occurred during this timeframe. Conclusion: This real-world study observed a very low incidence of bleeding complications and PE events, indicating that this care pathway of deferred DVT workup is safe and may offer a more streamlined diagnostic approach for patients with suspected DVT.
KW - Anticoagulation
KW - Deep venous thrombosis
KW - Diagnostic evaluation
U2 - 10.1016/j.ejim.2023.12.021
DO - 10.1016/j.ejim.2023.12.021
M3 - Article
SN - 0953-6205
VL - 122
SP - 54
EP - 60
JO - European journal of internal medicine
JF - European journal of internal medicine
ER -