Deep Learning for Fully-Automated Localization and Segmentation of Rectal Cancer on Multiparametric MR

Stefano Trebeschi, Joost J. M. van Griethuysen, Doenja M. J. Lambregts, Max J. Lahaye, Chintan Parmer, Frans C. H. Bakers, Nicky H. G. M. Peters, Regina G. H. Beets-Tan, Hugo J. W. L. Aerts*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

143 Citations (Web of Science)

Abstract

Multiparametric Magnetic Resonance Imaging (MRI) can provide detailed information of the physical characteristics of rectum tumours. Several investigations suggest that volumetric analyses on anatomical and functional MRI contain clinically valuable information. However, manual delineation of tumours is a time consuming procedure, as it requires a high level of expertise. Here, we evaluate deep learning methods for automatic localization and segmentation of rectal cancers on multiparametric MR imaging. MRI scans (1.5T, T2-weighted, and DWI) of 140 patients with locally advanced rectal cancer were included in our analysis, equally divided between discovery and validation datasets. Two expert radiologists segmented each tumor. A convolutional neural network (CNN) was trained on the multiparametric MRIs of the discovery set to classify each voxel into tumour or non-tumour. On the independent validation dataset, the CNN showed high segmentation accuracy for reader1 ( Dice Similarity Coefficient (DSC = 0.68) and reader2 (DSC = 0.70). The area under the curve (AUC) of the resulting probability maps was very high for both readers, AUC = 0.99 (SD = 0.05). Our results demonstrate that deep learning can perform accurate localization and segmentation of rectal cancer in MR imaging in the majority of patients. Deep learning technologies have the potential to improve the speed and accuracy of MRI-based rectum segmentations.

Original languageEnglish
Article number5301
Number of pages9
JournalScientific Reports
Volume7
DOIs
Publication statusPublished - 13 Jul 2017

Keywords

  • APPARENT DIFFUSION-COEFFICIENT
  • PREOPERATIVE CHEMORADIATION
  • IMAGE REGISTRATION
  • RADIATION-THERAPY
  • COMPLETE RESPONSE
  • WEIGHTED MRI
  • VOLUMETRY
  • CHEMORADIOTHERAPY
  • CHEMOTHERAPY

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