D-dimer Testing in Pulmonary Embolism with a Focus on Potential Pitfalls: A Narrative Review

Loris Wauthier; Julien Favresse; Michaël Hardy; Jonathan Douxfils; Grégoire Le Gal; Pierre-Marie Roy; Nick van Es; Cihan Ay; Hugo Ten Cate; Thierry Vander Borght; Michaël V Dupont; Thomas Lecompte; Giuseppe Lippi; François Mullier

doi:10.3390/diagnostics12112770

D-dimer Testing in Pulmonary Embolism with a Focus on Potential Pitfalls: A Narrative Review

Loris Wauthier, Julien Favresse, Michaël Hardy, Jonathan Douxfils, Grégoire Le Gal, Pierre-Marie Roy, Nick van Es, Cihan Ay, Hugo Ten Cate, Thierry Vander Borght, Michaël V Dupont, Thomas Lecompte, Giuseppe Lippi, François Mullier^*

^*Corresponding author for this work

Research output: Contribution to journal › (Systematic) Review article › peer-review

Abstract

D-dimer is a multifaceted biomarker of concomitant activation of coagulation and fibrinolysis, which is routinely used for ruling out pulmonary embolism (PE) and/or deep vein thrombosis (DVT) combined with a clinical pretest probability assessment. The intended use of the tests depends largely on the assay used, and local guidance should be applied. D-dimer testing may suffer from diagnostic errors occurring throughout the pre-analytical, analytical, and post-analytical phases of the testing process. This review aims to provide an overview of D-dimer testing and its value in diagnosing PE and discusses the variables that may impact the quality of its laboratory assessment.

Original language	English
Article number	2770
Number of pages	14
Journal	Diagnostics
Volume	12
Issue number	11
DOIs	https://doi.org/10.3390/diagnostics12112770
Publication status	Published - 12 Nov 2022

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10.3390/diagnostics12112770Licence: CC BY

Cite this

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title = "D-dimer Testing in Pulmonary Embolism with a Focus on Potential Pitfalls: A Narrative Review",

abstract = "D-dimer is a multifaceted biomarker of concomitant activation of coagulation and fibrinolysis, which is routinely used for ruling out pulmonary embolism (PE) and/or deep vein thrombosis (DVT) combined with a clinical pretest probability assessment. The intended use of the tests depends largely on the assay used, and local guidance should be applied. D-dimer testing may suffer from diagnostic errors occurring throughout the pre-analytical, analytical, and post-analytical phases of the testing process. This review aims to provide an overview of D-dimer testing and its value in diagnosing PE and discusses the variables that may impact the quality of its laboratory assessment.",

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AU - Wauthier, Loris

AU - Favresse, Julien

AU - Hardy, Michaël

AU - Douxfils, Jonathan

AU - Le Gal, Grégoire

AU - Roy, Pierre-Marie

AU - van Es, Nick

AU - Ay, Cihan

AU - Ten Cate, Hugo

AU - Vander Borght, Thierry

AU - Dupont, Michaël V

AU - Lecompte, Thomas

AU - Lippi, Giuseppe

AU - Mullier, François

PY - 2022/11/12

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N2 - D-dimer is a multifaceted biomarker of concomitant activation of coagulation and fibrinolysis, which is routinely used for ruling out pulmonary embolism (PE) and/or deep vein thrombosis (DVT) combined with a clinical pretest probability assessment. The intended use of the tests depends largely on the assay used, and local guidance should be applied. D-dimer testing may suffer from diagnostic errors occurring throughout the pre-analytical, analytical, and post-analytical phases of the testing process. This review aims to provide an overview of D-dimer testing and its value in diagnosing PE and discusses the variables that may impact the quality of its laboratory assessment.

AB - D-dimer is a multifaceted biomarker of concomitant activation of coagulation and fibrinolysis, which is routinely used for ruling out pulmonary embolism (PE) and/or deep vein thrombosis (DVT) combined with a clinical pretest probability assessment. The intended use of the tests depends largely on the assay used, and local guidance should be applied. D-dimer testing may suffer from diagnostic errors occurring throughout the pre-analytical, analytical, and post-analytical phases of the testing process. This review aims to provide an overview of D-dimer testing and its value in diagnosing PE and discusses the variables that may impact the quality of its laboratory assessment.

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DO - 10.3390/diagnostics12112770

M3 - (Systematic) Review article

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